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Research Lab Results for translational research

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  • Michael Kornberg Lab

    Lab Website

    Our laboratory conducts basic and translational research aimed at better understanding the path...ogenesis of multiple sclerosis (MS) and the role of the immune system in CNS disease, particularly the processes that drive progressive disability such as neurodegeneration and remyelination failure. We currently have three parallel research programs: 1. Metabolism as a modulator of MS: We are studying how basic metabolic pathways regulate the immune system and how these pathways might be exploited to protect neurons and myelin-forming oligodendrocytes from injury. 2. Identifying pathways by which nitric oxide (NO) and other free radicals cause neuronal and axonal damage. Our lab is identifying specific signaling pathways initiated by NO and other free radicals that can be targeted by drugs to produce neuroprotection. 3. Modulating the innate immune system in MS: In collaboration with others at Johns Hopkins, we are studying ways to enhance the reparative functions of microglia while preventing maladaptive responses. This work has identified bryostatin-1 as a potential drug that may be re-purposed for this task. view more

    Research Areas: multiple sclerosis
  • Nicholas Rowan Lab

    Dr. Rowan is actively involved in both outcomes and translational research relating to chronic ...rhinosinusitis and endoscopic skull base surgery. He has a keen interest patient-reported quality of life outcomes as well as those that pertain to smell and taste. Dr. Rowan is also involved in sinus-related clinical trials, pursuing new medical therapies and technological advancements for the treatment of patients with chronic rhinosinusitis. view more

    Research Areas: clinical trials, smell and taste outcomes, Quality of life outcomes
  • O'Rourke Lab

    Lab Website
    Principal Investigator:
    Brian O'Rourke, Ph.D.
    Medicine

    The O’Rourke Lab uses an integrated approach to study the biophysics and physiology of cardiac ...cells in normal and diseased states.

    Research in our lab has incorporated mitochondrial energetics, Ca2+ dynamics, and electrophysiology to provide tools for studying how defective function of one component of the cell can lead to catastrophic effects on whole cell and whole organ function. By understanding the links between Ca2+, electrical excitability and energy production, we hope to understand the cellular basis of cardiac arrhythmias, ischemia-reperfusion injury, and sudden death.

    We use state-of-the-art techniques, including single-channel and whole-cell patch clamp, microfluorimetry, conventional and two-photon fluorescence imaging, and molecular biology to study the structure and function of single proteins to the intact muscle. Experimental results are compared with simulations of computational models in order to understand the findings in the context of the system as a whole.

    Ongoing studies in our lab are focused on identifying the specific molecular targets modified by oxidative or ischemic stress and how they affect mitochondrial and whole heart function.

    The motivation for all of the work is to understand
    • how the molecular details of the heart cell work together to maintain function and
    • how the synchronization of the parts can go wrong

    Rational strategies can then be devised to correct dysfunction during the progression of disease through a comprehensive understanding of basic mechanisms.

    Brian O’Rourke, PhD, is a professor in the Division of Cardiology and Vice Chair of Basic and Translational Research, Department of Medicine, at the Johns Hopkins University.
    view more

    Research Areas: biophysics, ischemia-reperfusion injury, imaging, electrophysiology, cardiovascular, arrhythmia, physiology, sudden cardiac death, molecular biology, cardiac cells
  • Pulmonary Infection and Inflammation Research Lab

    Principal Investigator:
    Hongpeng Jia, M.D., M.Sc.
    Surgery

    The Jia lab performs basic and translational research into the mechanisms of and therapeutic st...rategy for viral and bacterial infection-induced inflammatory lung diseases, one of the leading causes of death in pulmonary diseases, especially for the ongoing pandemic of the SARS-CoV-2 mediated COVID-19. Our work has identified novel roles of Angiotensin-converting enzyme 2 (ACE2) in the inflammatory response to viral and bacterial lung infection and its complex contributions into the pathogenesis and disease progression and outcome of COVID-19. In seeking to translate these findings to clinical studies, we have been working on a collaboration with other investigators, developing novel diagnostic, preventive, and therapeutic tools in combating the devastating COVID-19, even in the era of effective vaccine prevention. These studies are funded by NIAID. view more

    Research Areas: RAS, viral and bacterial lung infection, inflammatory lung disease
  • Shaoyong Yu Lab

    Principal Investigator:
    Shaoyong Yu, M.D.
    Medicine

    The Yu Lab does basic and translational research on Sensory physiology and disorders of the gas...trointestinal tract.

    view more

    Research Areas: Sensory physiology and disorders of the gastrointestinal tract
  • Spinal Column Biomechanics Lab

    Lab Website
    Principal Investigator:
    Ali Bydon, M.D.
    Neurosurgery

    The Spinal Column Biomechanics Laboratory focuses on the study of various spinal pathologies. T...he Biomechanics Laboratory studies a wide array of tools and techniques in order to advance spinal surgery for the benefit of patients. With a team of researchers, engineers, and neurosurgeons, the Biomechanics Laboratory participates in the newest developments in applied and translational research. Our facility alongside the International Center for Orthopaedic Advancement at the Johns Hopkins Bayview Medical Center serves as a premiere learning institute. The laboratory not only conducts novel biomechanical studies but also functions as a teaching facility for neurosurgical trainees interested in mastering highly specialized or technical procedures.The Spinal Column Biomechanics Laboratory specializes in applied mechanics, force vector analysis, spinal instrumentation testing and development of novel spinal reconstructions. view more

    Research Areas: spine
  • Subhash Kulkarni Lab

    Lab Website
    Principal Investigator:
    Subhash Kulkarni, Ph.D., M.S.
    Medicine

    The Subhash Kulkarni Lab performs basic and translational research on disorders of neurogastroe...nterology and motility. view more

    Research Areas: Disorders of neurogastroenterology and motility
  • Supendymoma and Ependymoma Research Center

    Lab Website
    Principal Investigator:
    Henry Brem, M.D.
    Neurosurgery

    The Johns Hopkins comprehensive Subependymoma and Ependymoma Research Center divideS its effort...s into three areas: basic science, translational research and clinical practice. Each division works separately but shares findings and resources openly with each other and our collaborators. The goal of our united efforts is to optimize current treatments to affect the care received by patients with subependymomas and ependymomas. Also, our clinical, translational and basic science teams work to develop novel therapies to improve and extend the lives of those with these rare tumors. view more

    Research Areas: brain cancer
  • The Cohen Lab

    Principal Investigator:
    Keira Cohen, M.D.
    Medicine

    Combining microbiology and bioinformatics, the Cohen Lab conducts translational research on myc...obacteria. By application of advanced genomic techniques to the problems of tuberculosis and nontuberculous mycobacteria, the Cohen Lab aims to develop improved tools for the diagnosis and management of mycobacterial disease. view more

    Research Areas: nontuberculous mycobacteria, genomics, drug resistance, tuberculosis
  • Tinsay Woreta

    Principal Investigator:
    Tinsay Woreta, M.D., M.P.H.
    Medicine

    The Woreta Lab does clinical and translational research on Hepatocellular Carcinoma; Liver Tran...splantation Outcomes; Chronic Viral Hepatitis.
    view more

    Research Areas: Chronic Viral Hepatitis, Liver Transplantation Outcomes, hepatocellular carcinoma
  • Varsha Singh

    Principal Investigator:
    Varsha Singh, Ph.D.
    Medicine

    The Singh Lab does basic and translational research on intestinal ion transport, cellular physi...ology, and membrane trafficking in diabetic disorders.

    view more

    Research Areas: Intestinal ion transport, cellular physiology, membrane trafficking in diabetic disorders
  • Vikesh Singh

    Principal Investigator:
    Vikesh Singh, M.D., M.Sc.
    Medicine

    The Singh lab does clinical and translational research on pancreatic islet isolation and transp...lantation as well as acute and chronic pancreatitis.

    view more

    Research Areas: Pancreatic islet isolation and transplantation, pancreatitis
  • Yukari Manabe Lab

    Principal Investigator:
    Yuka Manabe, M.D.
    Medicine

    Investigators in the Yukari Manabe Lab evaluate the accuracy of rapid, point-of-care diagnostic...s for HIV, tuberculosis and related infectious diseases in resource-limited settings particularly sub-Saharan Africa and examine the impact of diagnostic interventions on disease detection and patient outcomes. The team also conducts operational and translational research in tuberculosis and HIV co-infection. view more

    Research Areas: Africa, infectious disease, AIDS, HIV, point-of-care diagnostics, resource limitations, tuberculosis
  • Zsuzsanna McMahan Lab

    Lab Website
    Principal Investigator:
    Zsuzsanna McMahan, M.D., M.H.S.
    Medicine

    The Zsuzsanna McMahan Lab conducts translational research that seeks to identify the novel anti...gens in scleroderma and to define the target tissue in this disease. We are conducting two active clinical research trials, including one that studies skin biopsy specimens as biomarkers of scleroderma and the response to mycophenolate mofetil (MMF or Cellcept). The other study is a gastrointestinal involvement registry that follows patients who are experiencing GERD, small bowel bacterial overgrowth, constipation, fecal incontinence and gastroparesis to see if there is improvement in symptoms after a change in treatment is implemented. view more

    Research Areas: gastrointestinal system, rheumatology, biomarkers, scleroderma, antigens, mycophenolate mofetil
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