Find a Research Lab

Enter a research interest, principal investigator or keyword

Displaying 21 to 22 of 22 results for tissues

Show: 10 · 20 · 50

  1. 1
  2. 2
  3. 3
  • The Burns Lab

    Our research laboratory studies the roles mobile DNAs play in human disease. Our group was one of the first to develop a targeted method for amplifying mobile DNA insertion sites in the human genome, and we showed that these are a significant source of structural variation (Huang et al., 2010). Since that time, our group has continued to develop high throughput tools to characterize these understudied sequences in genomes and to describe the expression and genetic stability of interspersed repeats in normal and malignant tissues. We have developed a monoclonal antibody to one of the proteins encoded for by Long INterspersed Element-1 (LINE-1) and showed its aberrant expression in a wide breadth of human cancers (Rodi? et al., 2014). We have demonstrated acquired LINE-1 insertion events during the evolution of metastatic pancreatic ductal adenocarcinoma and other gastrointestinal tract tumors (Rodi? et al., 2015). We have major projects focused on studying functional consequences of inh...erited sequence variants, and exciting evidence that these predispose to cancer risk and other disease phenotypes. Our laboratory is using a combination of genome wide association study (GWAS) analyses, custom RNA-seq analyses, semi-high throughput gene expression reporter assays, and murine models to pursue this hypothesis. view more

    Research Areas: cancer, DNA, malignant tumors

    Lab Website

    Principal Investigator

    Kathleen Burns, M.D., Ph.D.

    Department

    Pathology

  • The Halushka Lab

    The Halushka laboratory is interested in the overarching question of expression localization in tissues. To address this, the laboratory has set out upon several avenues of discovery in the areas of microRNA expression, proteomics and tissue gene expression. Many of these queries relate to the cardiovascular field as Dr. Halushka is a cardiovascular pathologist. Come learn about the science being done in the laboratory.

    Research Areas: genomic sciences, cardiovascular, genomic technologies, cardiovascular diseases

    Lab Website

    Principal Investigator

    Marc Halushka, M.D., Ph.D.

    Department

    Pathology

  1. 1
  2. 2
  3. 3