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Research Lab Results for synaptic plasticity

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  • Albert Lau Lab

    Lab Website
    Principal Investigator:
    Albert Lau, Ph.D.
    Biophysics and Biophysical Chemistry

    The Lau Lab uses a combination of computational and experimental approaches to study the atomic... and molecular details governing the function of protein complexes involved in intercellular communication. We study ionotropic glutamate receptors (iGluRs), which are ligand-gated ion channels that mediate the majority of excitatory synaptic transmission in the central nervous system. iGluRs are important in synaptic plasticity, which underlies learning and memory. Receptor dysfunction has been implicated in a number of neurological disorders. view more

    Research Areas: central nervous system, synaptic plasticity, computational biology, intracellular communication, ionotropic glutamate receptors, neurological disorders
  • David Linden Lab

    Principal Investigator:
    David Linden, Ph.D.
    Neuroscience

    The David Linden Laboratory has used both electrode and optical recording in cerebellar slice a...nd culture model systems to explore the molecular requirements for induction and expression of these phenomena. Along the way, we discovered a new form of plasticity. In addition, we have expanded our analysis to include use-dependent synaptic and non-synaptic plasticity in the cerebellar output structure, the deep nuclei.

    Our investigations are central to understanding the cellular substrates of information storage in a brain area where the behavioral relevance of the inputs and outputs is unusually well defined. In addition, our investigations have potential clinical relevance for cerebellar motor disorders and for disorders of learning and memory generally.
    view more

    Research Areas: motor learning, synaptic plasticity, neurobiology, memory, cerebellum, brain
  • Laboratory of Richard L. Huganir

    Lab Website
    Principal Investigator:
    Richard Huganir, Ph.D.
    Neuroscience

    The Laboratory of Richard L. Huganir is interested in the mechanisms that regulate synaptic tra...nsmission and synaptic plasticity. Our general approach is to study molecular and cellular mechanisms that regulate neurotransmitter receptors and synapse function. We are currently focusing our efforts on the mechanisms that underlie the regulation of the glutamate receptors, the major excitatory neurotransmitter receptors in the brain. view more

    Research Areas: synapses, neurotransmitters, cell biology, brain, molecular biology
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