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  • Robert Wise Lab

    Principal Investigator:
    Robert Wise, M.D.
    Medicine

    The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD).... We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma. view more

    Research Areas: critical care medicine, emphysema, scleroderma, pulmonary medicine, asthma, lung-volume reduction surgery, COPD
  • Roberto Salvatori Lab

    Principal Investigator:
    Roberto Salvatori, M.D.
    Medicine

    Research in the Roberto Salvatori Lab focuses on the genetic causes of isolated growth hormone ...deficiency (GHD), consequences of untreated GHD, and cortisol excess and deficiency. Current work explores GHD’s relation to obesity and indicates that Cushing's syndrome may be under-recognized in patients undergoing bariatric surgery. We recently took part in a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients, a condition that has not been studied previously in a standardized way. view more

    Research Areas: pituitary gigantism, growth hormone deficiency, hypercortisolism, endocrinology
  • Saowanee Ngamruengphong Lab

    Principal Investigator:
    Saowanee Ngamruengphong, M.D.
    Medicine

    Research in the Saowanee Ngamruengphong Lab focuses on methods for diagnosing and managing gast...rointestinal conditions, including premalignant and malignant lesions of the gastrointestinal tract, esophageal cancer, colon polyps, and biliary and pancreatic disease. Our most recent work includes investigating a novel hybrid technique for closure of refractory gastrocutaneous fistula. We also conducted an international multicenter study that compared endoscopic ultrasound-guided pancreatic duct drainage with enteroscopy-assisted endoscopic retrograde pancreatography following Whipple surgery. view more

    Research Areas: colon polyps, cancer, endoscopy, pancreatic disease, gastric cancer, ultrasound, gastrointestinal
  • Singh Lab: Stem Cell Transplant Group

    Lab Website

    The goal of the Singh Lab is to cure retinal degeneration due to genetic disease in patients. T...here are many retinal diseases such as Stargardts, Macular Degeneration, and Retinitis Pigmentosa, that are currently incurable. These diseases damage and eventually eliminate photoreceptors in the retina. The lab's aim is to take healthy photoreceptors derived from stem cells and transplant them into the patient’s retina to replace the lost photoreceptors. The transplanted photoreceptors are left to mature, make connections with the recipient’s remaining retina, and restore vision. Further, the lab is most interested in the cone-photoreceptor rich region of the macula, which is the central zone of the human retina, enabling high-acuity vision for tasks such as facial recognition and reading. view more

    Research Areas: photoreceptor transplantation, retinal surgery technology and device development, retinal stem cell transplantation, clinical trials in retinal gene therapy
  • Spinal Column Biomechanics Lab

    Lab Website
    Principal Investigator:
    Ali Bydon, M.D.
    Neurosurgery

    The Spinal Column Biomechanics Laboratory focuses on the study of various spinal pathologies. T...he Biomechanics Laboratory studies a wide array of tools and techniques in order to advance spinal surgery for the benefit of patients. With a team of researchers, engineers, and neurosurgeons, the Biomechanics Laboratory participates in the newest developments in applied and translational research. Our facility alongside the International Center for Orthopaedic Advancement at the Johns Hopkins Bayview Medical Center serves as a premiere learning institute. The laboratory not only conducts novel biomechanical studies but also functions as a teaching facility for neurosurgical trainees interested in mastering highly specialized or technical procedures.The Spinal Column Biomechanics Laboratory specializes in applied mechanics, force vector analysis, spinal instrumentation testing and development of novel spinal reconstructions. view more

    Research Areas: spine
  • Spinal Column Surgical Outcomes Lab

    Lab Website
    Principal Investigator:
    Ali Bydon, M.D.
    Neurosurgery

    The Spinal Column Surgical Outcomes Laboratory aims to improve the neurological outcomes and fu...nctional capacity of patients undergoing spinal surgery. We collect large-scale retrospective patient databases and prospective patient registries to report high-quality data relating to the outcomes of neurosurgical operations. The laboratory participates in the National neurosurgical Quality and Outcomes Database (N2QOD). This multi-institutional collaboration has set forth a 3-year prospective study to benchmark quality and surgical outcome measures across several academic institutions. The Spinal Column Surgical Outcomes Laboratory specializes in biostatistical analysis of large-scale clinical databases, studying the outcomes of traditional and novel spinal procedures, quality control and cost-effectiveness research and clinical trials relating to spinal surgery outcomes. view more

    Research Areas: spine
  • Steven Frank Lab

    Research in the Steven Frank Lab focuses on processes to improve blood use and to avoid blood t...ransfusions for patients who do not want to receive blood or blood products. Processes include autologous hemodilution and cell salvage, and treating or averting anemia pre- and post-surgery. Other lab studies have focused on blood conservation, bloodless medicine surgery, the regulation of body temperature during surgery and methods of preventing hypothermia during surgery. view more

    Research Areas: bloodless surgery, blood disorders, hypothermia, blood transfusions, blood conservation, cell salvage, anemia, autologous hemodilution, bloodless medicine
  • The Atlantic Cardiovascular Patient Outcomes Research Team - Atlantic C-PORT

    Principal Investigator:
    Thomas Aversano, M.D.
    Medicine

    Our research is centered on the safety, efficacy and outcomes of PCI performed at hospitals wit...hout on-site cardiac surgery.

    Active projects:

    C-PORT Randomized Studies and Registries; New Jersey Angioplasty Demonstration Project; InCar-decision support tools for performance of PCI at hospitals without on-site cardiac surgery.

    For more information please visit Cport.org.
    view more

    Research Areas: cardiac surgery, cardiology
  • The Boss Lab

    The Boss Lab's research focus is on patient experience, health disparities, and surgical outcom...es and utilization. Studies include shared decision-making, communication, and patient/parent-reported outcomes for elective surgery in children; patient satisfaction metrics, outcomes, and health correlates in surgery and pediatrics; patient and family-centered care and communication in surgery and pediatrics; racial, ethnic, and socioeconomic disparities in pediatric surgical care utilization and outcomes; and quality and safety in pediatric surgical care view more

    Research Areas: communication, quality and safety in pediatric surgical care, disparities in pediatric care, pediatric surgical care, family-centered care
  • The Functional Neurosurgery Lab

    Lab Website
    Principal Investigator:
    Fred Lenz, M.D.
    Neurosurgery

    The studies of the Functional Neurosurgery Lab currently test whether neural activity related t...o the experimental vigilance and conditioned expectation toward pain can be described by interrelated networks in the brain. These two psychological dimensions play an important role in chronic pain syndromes, but their neuroscience is poorly understood. Our studies of spike trains and LFPs utilize an anatomically focused platform with high temporal resolution, which complements fMRI studies surveying the whole brain at lower resolution. This platform to analyze the oscillatory power of structures in the brain, and functional connections (interactions and synchrony and causal interactions) between these structures based upon signals recorded directly from the waking human brain during surgery for epilepsy and movement disorders, e.g. tremor. Our studies have demonstrated that behaviors related to vigilance and expectation are related to electrical signals from the cortex and subcortical structures.

    These projects are based upon the combined expertise of Dr. Nathan Crone in recordings and clinical management of the patients studied; Dr. Anna Korzeniewska in the analyses of signals recorded from the brain; Drs. Claudia Campbell, Luana Colloca and Rick Gracely in the clinical psychology and cognitive neurology of the expectation of pain and chronic pain; Dr. Joel Greenspan in quantitative sensory testing; and Dr. Martin Lindquist in the statistical techniques. Dr. Lenz has conducted studies of this type for more than thirty years with continuous NIH funding.
    view more

    Research Areas: neurosurgery, epilepsy, movement disorders, pain
  • The Spinal Fusion Laboratory

    Lab Website
    Principal Investigator:
    Timothy Witham, M.D.
    Neurosurgery

    Five to 35 percent of spine fusionprocedures fail, even when using the gold standard treatment ...of grafting bone from the patient's own iliac crest. Fusion failure, otherwise known as pseudoarthrosis, is a major cause of failed back surgery syndrome (FBSS) and results in significant pain and disability, increasing the need for additional procedures and driving up health care costs. The ultimate goal of the Spinal Fusion Laboratory is to eliminate pseudoarthrosis by using animal models to study various strategies for improving spinal fusion outcomes, including delivery of various growth factors and biological agents; stem cell therapies and tissue engineering approaches. view more

    Research Areas: failed spine surgery, pseudoarthrosis, spine fusion
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