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The Gabelli lab research is focused on structural, mechanistic and functional aspects of enzyme activation that play a role in the biology of human diseases such as cancer, parasitic infection and cardiovascular disease. Their work seeks to:
1. Understand how molecular events at the recognition level coordinate and trigger events in the cells
2. Translate structural and mechanistic information on protein:protein interactions at the cytoplasmic level into preventive and therapeutic treatment for human disease.
To achieve a comprehensive understanding, they are studying cytoplasmic protein-protein interactions involved in regulation of pathways such as PI3K and Sodium Voltage gated channels. Their research integrates structural biology and chemical biology and it is focused on drug discovery for targeted therapies.
The Structural Enzymology and Thermodynamics Group uses a combination of molecular biology, biochemistry and structural biology to understand the catalytic mechanisms of several enzyme families. Additionally, researchers in the group are studying protein-ligand interactions using structural dynamics. They are able to apply their knowledge of the mechanisms of these enzymes and of binding energetics to develop targets for drug design.
The Urban Lab studies rhomboid proteases--a class of enzymes that cut proteins to initiate signaling between cells as a form of communication that organizes embryo development. Current studies in the lab focus on the biophysics of how these enzymes function inside the cell membrane, where it's hard for catalysis to take place. Because rhomboid intramembrane proteolysis plays a central role in malaria infection and Parkinson's disease pathogenesis, these studies may have therapeutic implications.
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