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Research Lab Results for stroke

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  • Post Lab

    Lab Website
    Principal Investigator:
    Wendy Post, M.D., M.S.
    Medicine

    The Post Lab is involved in the Multi-Ethnic Study of Atherosclerosis (MESA), a collaborative s...tudy of the characteristics of subclinical cardiovascular disease (that is, disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.

    As MESA researchers, we study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.

    Participants were recruited from six field centers across the United States, including Johns Hopkins University. Each participant received an extensive physical exam to determine a number of conditions, including coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors.

    Selected repetition of subclinical disease measures and risk factors at follow-up visits have allowed study of the progression of disease. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality.

    Wendy S. Post, MD, MS, is an associate faculty, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, and a professor of medicine.
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    Research Areas: coronary artery disease, cardiovascular, ethnicity, pathogenesis, atherosclerosis, sudden cardiac death
  • S.C.O.R.E. Lab

    Lab Website
    Principal Investigator:
    Argye Hillis, M.D.
    Neurology

    The mission of the Stroke Cognitive Outcomes and Recovery (S.C.O.R.E.) Lab is to enhance knowle...dge of brain mechanisms that allow people recover language, empathy, and other cognitive and communicative functions after stroke, and to improve ways to facilitate recovery of these functions after stroke. We also seek to improve the understanding of neurobiology of primary progressive aphasia., and how to enhance communication in people with this group of clinical syndromes. view more

    Research Areas: cerebrovascular, cognitive neuroscience, dementia
  • Stephen Sozio Lab

    Principal Investigator:
    Stephen Sozio, M.D.
    Medicine

    Dr. Sozio’s research focuses on 1) Clinical research related to chronic kidney disease and end ...stage renal disease, and 2) Educational research in undergraduate and graduate medical education.



    The Sozio lab pursues work related to stroke, cognitive impairment, manifestations of kidney disease, and systematic reviews on clinical topics, and collaborates on multiple projects with other key investigators. In particular, Dr. Sozio has been an active investigator in the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study, Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) Study, Chronic Renal Insufficiency Cohort (CRIC) Study, and work funded through the Agency for Healthcare Research and Quality (AHRQ) and Johns Hopkins Evidence-Based Practice Center. In addition, the Sozio lab performs studies at the UME and GME levels, investing in understanding learners’ mentorship, research, and transitional experiences.
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    Research Areas: end stage renal disease (ESRD), epidemiology, kidney diseases, stroke
  • Swallowing Investigation in Physiology (SIP) Lab

    Lab Website

    The SIP Lab studies the mechanisms of normal and disordered swallowing. The team conducts resea...rch in the areas of swallowing rehabilitation after stroke, effects of aging on swallowing and measurement of swallowing physiology. view more

    Research Areas: deglutition, swallowing disorders, dysphagia, neurophysiology, stroke, aging, 320-row area detector, MRI, swallowing, physiology, videofluoroscopy, rehabilitation
  • The Pathak Lab

    Lab Website

    The Pathak lab is within the Division of Cancer Imaging Research in the Department of Radiology... and Radiological Science. We develop novel imaging methods, computational models and visualization tools to ‘make visible’ critical aspects of cancer, stroke and neurobiology. Our research broadly encompasses the following areas: Functional and Molecular Imaging; Clinical Biomarker Development; Image-based Systems Biology and Visualization and Computational Tools. We are dedicated to mentoring the next generation of imagers, biomedical engineers and visualizers. Additional information can be found at www.pathaklab.org or by emailing Dr. Pathak. view more

    Research Areas: microscopy, vasculature, tumors, systems biology, functional magnetic resonance imaging, 3D imaging, biomarkers, optical imaging, angiogenesis, cancer imaging
  • Tsapkini Language Neuromodulation Lab

    Lab Website
    Principal Investigator:
    Kyrana Tsapkini, Ph.D.
    Neurology

    We are exploring whether anodal tDCS when administered in combination with spelling, naming, or... working memory therapy can improve language performance of PPA and MCI participants at least in the short term more than behavioral therapy alone. We are also investigating whether and how tDCS alters the neuropeptide signature in participants with PPA and MCI. We use proton magnetic resonance spectroscopy (1H-MRS) to monitor neuropeptide concentrations at the areas of stimulation. We hypothesize that tDCS will stabilize the decline of specific neuropeptides, but only in those areas of the brain where tDCS effectively results in more efficient gains in language compared to language therapy alone (with sham tDCS). Study results may help optimize future intervention in individuals with PPA and MCI by providing treatment alternatives in a neurodegenerative condition with no proven effective treatment. A better understanding of the therapeutic and neuromodulatory effects of tDCS in PPA and MCI will offer insight into ways of impeding neurodegeneration that may improve quality of life for individuals with PPA and MCI and may provide insights into the mechanisms of this treatment for augmenting therapy for stroke as well. view more

    Research Areas: cognitive neuroscience, dementia
  • Zeiler Stroke Recovery Lab

    Lab Website
    Principal Investigator:
    Steven Zeiler, M.D., Ph.D.
    Neurology

    Improved acute stroke care means that more patients are surviving. Unfortunately, up to 60 perc...ent of stroke survivors suffer disability in arm or leg use, and 30 percent need placement in a longer term care facility. Recovering motor skills after stroke is essential to rehabilitation and the restoration of a meaningful life. Therefore, there is an urgent need to develop innovative new approaches to rehabilitation. Most recovery from motor impairment after stroke occurs in the first month and is largely complete by three months. Improvement occurs independently of rehabilitative interventions (for example, physical and occupational therapy), which predominantly target function through compensatory strategies that do not constitute true recovery. Dr. Zeiler and his team are conducting research to uncover how to augment and prolong this critical window of time. view more

    Research Areas: cerebrovascular dysfunction, cerebrovascular, stroke, rehabilitation
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