Research Lab Results for stress
Alison Miles LabPrincipal Investigator:
Alison Miles, D.O.
Anesthesiology and Critical Care Medicine
Research in the Alison Miles Lab focuses on moral distress among pediatric intensive care unit ...(PICU) clinicians. We have interviewed practitioners involved in the long-term care of patients in the PICU from two months to two years. By identifying the challenges of these cases and what was learned, we hope to develop more effective stress-management strategies for providers. Providers who have less stress are better equipped to care for patients, including those living with chronic diseases. Our team hopes to ultimately improve the field of pediatric palliative care for patients, families and care providers. view moreResearch Areas: stress, intensive care
Cardio-Obstetrics ResearchLab WebsitePrincipal Investigator:
Jason Vaught, M.D.
Gynecology and Obstetrics
Under the division of Maternal-Fetal Medicine, our Cardio-Obstetric research efforts seek to ad...vance the field of gynecology through medical care and innovation. With a focus on the effect of heart conditions on pregnancy and the ways in which pregnancy can put stress on your heart and circulatory system, our goal in this multi-disciplinary research is that our findings may lead to the development of new treatments or preventative therapies for patients and their babies to better manage a heart condition during pregnancy. view moreResearch Areas: heart conditions during pregnancy, heart conditions on pregnancy
Edgar Miller LabPrincipal Investigator:
Edgar Miller, M.D., Ph.D.
Research in the Edgar Miller Lab focuses on nutrition, hypertension and kidney disease. Current... projects include a National Heart, Lung, and Blood Institute study on dietary carbohydrate and glycemic index effects on markers of oxidative stress, inflammation and kidney function; and a National Institute of Diabetes and Digestive and Kidney Diseases randomized controlled trial that examines the effects of omega-3 fatty acid supplementation on urine protein excretion in diabetic kidney disease. view moreResearch Areas: nutrition, kidney diseases, diabetes, inflammation
Gary Wand LabPrincipal Investigator:
Gary Wand, M.D.
Research conducted in the Gary Wand Lab focuses on neuropsychoendocrinology; the neurobiology o...f substance abuse; physiogenetics and regulation of the stress response; and the relationship between stress and chemical dependency. Current studies seek to better understand the genetic determinants of the stress response and how excessive stress hormone production contributes to neurobiological disorders, including addiction. view moreResearch Areas: neurobiology, substance abuse, stress, hormones, physiogenetics, neuropsychoendocrinology, alcoholism
Healthy Brain ProgramLab WebsitePrincipal Investigator:
Leah Rubin, Ph.D., M.A., M.P.H.
Psychiatry and Behavioral Sciences
The Brain Health Program is a multidisciplinary team of faculty from the departments of neurolo...gy, psychiatry, epidemiology, and radiology lead by Leah Rubin and Jennifer Coughlin. In the hope of revealing new directions for therapies, the group studies molecular biomarkers identified from tissue and brain imaging that are associated with memory problems related to HIV infection, aging, dementia, mental illness and traumatic brain injury. The team seeks to advance policies and practices to optimize brain health in vulnerable populations while destigmatizing these brain disorders.Research Areas: HIV infection, mental illness, aging, traumatic brain injury, dementia
Current and future projects include research on: the roles of the stress response, glucocorticoids, and inflammation in conditions that affect memory and the related factors that make people protected or or vulnerable to memory decline; new mobile apps that use iPads to improve our detection of memory deficits; clinical trials looking at short-term effects of low dose hydrocortisone and randomized to 28 days of treatment; imaging brain injury and repair in NFL players to guide players and the game; and the role of inflammation in memory deterioration in healthy aging, patients with HIV, and other neurodegenerative conditions. view more
Jungsan SohnLab WebsitePrincipal Investigator:
Jungsan Sohn, Ph.D.
Biophysics and Biophysical Chemistry
Dr. Sohn's lab is interested in understanding how biological stress-sensors are assembled, dete...ct danger signals and initiate stress response.Research Areas: immunology, cell biology, cancer, eukaryotes, stress sensors
Innate immunity is the first line of defense against invading pathogens in higher eukaryotes. We are using in vitro quantitative biochemical assays and mutagenesis and x-ray crystallography to investigate the underlying operating principles of inflammasomes, a component of the innate immune system, to better understand biological stress sensors. view more
Kass LabLab WebsitePrincipal Investigator:
David Kass, M.D.
Basic science investigations span an array of inquiries, such as understanding the basic mechan...isms underlying cardiac dyssynchrony and resynchronization in the failing heart, and beneficial influences of nitric oxide/cGMP/protein kinase G and cGMP-targeted phosphdiesterase signaling cascades on cardiac maladaptive stress remodeling. Recently, the latter has particularly focused on the role of phosphodiesterase type 5 and its pharmacologic inhibitors (e.g. sildenafi, Viagra®), on myocyte signaling cascades modulated by protein kinase G, and on the nitric oxide synthase dysregulation coupled with oxidant stress.Research Areas: pulmonary hypertension, heart disease, cardiac hypertrophy, heart failure, cardiology
The lab also conducts clinical research and is presently exploring new treatments for heart failure with a preserved ejection fraction, studying ventricular-arterial interaction and its role in adverse heart-vessel coupling in left heart failure and pulmonary hypertension, and testing new drug, device, and cell therapies for heart disease. A major theme has been with the use of advanced non-invasive and invasive catheterization-based methods to assess cardiac mechanics in patients.asive and invasive catheterization-based methods to assess cardiac mechanics in patients.
David Kass, MD, is currently the Director at the Johns Hopkins Center for Molecular Cardiobiology and a professor in cellular and molecular medicine. view more
Lee Martin LaboratoryLab WebsitePrincipal Investigator:
Lee Martin, Ph.D.
In the Lee Martin Laboratory, we are testing the hypothesis that selective vulnerability--the p...henomenon in which only certain groups of neurons degenerate in adult onset neurological disorders like amyotrophic lateral sclerosis and Alzheimer's disease--is dictated by brain regional connectivity, mitochondrial function and oxidative stress. We believe it is mediated by excitotoxic cell death resulting from abnormalities in excitatory glutamatergic signal transduction pathways, including glutamate transporters and glutamate receptors as well as their downstream intracellular signaling molecules.Research Areas: ALS, neurodegeneration, selective vulnerability, cell death, Alzheimer's disease
We are also investigating the contribution of neuronal/glial apoptosis and necrosis as cell death pathways in animal (including transgenic mice) models of acute and progressive neurodegeneration. We use a variety of anatomical and molecular neurobiological approaches, including neuronal tract-tracing techniques, immunocytochemistry, immunoblotting, antipeptide antibody production, transmission electron microscopy and DNA analysis to determine the precise regional and cellular vulnerabilities and the synaptic and molecular mechanisms that result in selective neuronal degeneration.
Machine Biointerface LabLab WebsitePrincipal Investigator:
Gene Fridman, Ph.D., M.S.
Otolaryngology - Head and Neck Surgery
Dr. Fridman's research group invents and develops bioelectronics for Neuroengineering and Medic...al Instrumentation applications. We develop innovative medical technology and we also conduct the necessary biological studies to understand how the technology could be effective and safe for people.Research Areas: medical instruments, bioelectricities, neuroengineering, nerve stimulation
Our lab is currently focused on developing the "Safe Direct Current Stimulation" technology, or SDCS. Unlike the currently available commercial neural prosthetic devices, such as cochlear implants, pacemakers, or Parkinson's deep brain stimulators that can only excite neurons, SDCS can excite, inhibit, and even sensitize them to input. This new technology opens a door to a wide range of applications that we are currently exploring along with device development: e.g. peripheral nerve stimulation for suppressing neuropathic pain, vestibular nerve stimulation to correct balance disorders, vagal nerve stimulation to suppress an asthma attack, and a host of other neuroprosthetic applications.
Medical Instrumentation MouthLab is a "tricorder" device that we invented here in the Machine Biointerface Lab. The device currently obtains all vital signs within 60s: Pulse rate, breathing rate, temperature, blood pressure, blood oxygen saturation, electrocardiogram, and FEV1 (lung function) measurement. Because the device is in the mouth, it has access to saliva and to breath and we are focused now on expanding its capability to obtaining measures of dehydration and biomarkers that could be indicative of a wide range of internal disorders ranging from stress to kidney failure and even lung cancer.
Molecular Mechanisms of Cellular Mechanosensing (Robinson Lab)Lab WebsitePrincipal Investigator:
Douglas Robinson, Ph.D., M.Phil.
The Robinson Lab studies the way in which mechanical stress guide and direct the behavior of ce...lls, including when they are part of tissues, organs and organ systems. view moreResearch Areas: cellular mechanosensing, tissues, organs, molecular biology