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Research Lab Results for stem cells

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  • Kendall Moseley Lab

    Principal Investigator:
    Kendall Moseley, M.D.
    Medicine

    Research in the Kendall Moseley Lab is focused on the interplay between type 2 diabetes, aging ...and osteoporosis. We also study the function of bone stem cells in the regulation of bone remodeling. view more

    Research Areas: type 2 diabetes, osteoporosis, stem cells, aging
  • Kunisaki Lab

    Principal Investigator:
    Shaun Kunisaki, M.D., M.Sc.
    Surgery

    The Kunisaki lab is a R01-funded regenerative medicine group within the Division of General ...Pediatric Surgery at Johns Hopkins that works at the interface of stem cells, mechanobiology, and materials science. We seek to understand how biomaterials and mechanical forces affect developing tissues relevant to pediatric surgical disorders. To accomplish these aims, we take a developmental biology approach using induced pluripotent stem cells and other progenitor cell populations to understand the cellular and molecular mechanisms by which fetal organs develop in disease.


    Our lab projects can be broadly divided into three major areas: 1) fetal spinal cord regeneration 2) fetal lung development 3) esophageal regeneration


    Lab members: Juan Biancotti, PhD (lab manager); Lynn Zhou, PhD (postdoc), Shelby Sferra, MD, MPH (postdoc); Annalise Penikis, MD (postdoc)


    Recent publications:
    Kunisaki SM, Jiang G, Biancotti JC, Ho KKY, Dye BR, Liu AP, Spence JR. Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of congenital diaphragmatic hernia fetal lung. Stem Cells Translational Medicine 2021, PMID: 32949227


    Biancotti JC, Walker KA, Jiang G, Di Bernardo J, Shea LD, Kunisaki SM. Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in an ex vivo model of prenatal spina bifida repair. Journal of Tissue Engineering 2020, PMID: 32782773.


    Kunisaki SM. Amniotic fluid stem cells for the treatment of surgical disorders in the fetus and neonate. Stem Cells Translational Medicine 2018, 7:767-773

    view more

    Research Areas: fetal therapy, stem cells, pediatric surgery, tissue engineering, congenital diaphragmatic hernia, myelomeningocele
  • Laboratory for Fetal and Neonatal Organ Regeneration

    Principal Investigator:
    Shaun Kunisaki, M.D., M.Sc.
    Surgery

    Researchers in the Laboratory for Fetal and Neonatal Organ Regeneration in the Department of Su...rgery at the Johns Hopkins School of Medicine are studying whether cellular reprogramming, stem cells, and ex vivo modeling can be applied to improve organ regeneration in pediatric surgical patients.

    To execute these aims, the lab collaborates with developmental biologists and biomedical engineers throughout the country and employs cutting-edge molecular strategies and pre-clinical animal models.
    view more

    Research Areas: stem cells, pediatric surgery, congenital anomalies, tissue engineering
  • Richard John Jones Lab

    Principal Investigator:
    Richard Jones, M.D.
    Medicine

    The Richard J. Jones Lab studies normal and cancerous stem cells in order to make clinical impr...ovements in areas such as blood and marrow transplantation (BMT). We discovered one of the most common stem-cell markers, Aldefluor, which identifies cells based on their expression of aldehyde dehydrogenase 1 (ALDH1), and have used this marker to detect and characterize normal stem cells and cancer stem cells from many hematologic malignancies. We also developed post-transplant cyclophosphamide and effective related haploidentical BMT. view more

    Research Areas: enzymes, stem cells, blood and marrow transplantation, leukemia, cancer
  • Singh Lab: Stem Cell Transplant Group

    Lab Website

    The goal of the Singh Lab is to cure retinal degeneration due to genetic disease in patients. T...here are many retinal diseases such as Stargardts, Macular Degeneration, and Retinitis Pigmentosa, that are currently incurable. These diseases damage and eventually eliminate photoreceptors in the retina. The lab's aim is to take healthy photoreceptors derived from stem cells and transplant them into the patient’s retina to replace the lost photoreceptors. The transplanted photoreceptors are left to mature, make connections with the recipient’s remaining retina, and restore vision. Further, the lab is most interested in the cone-photoreceptor rich region of the macula, which is the central zone of the human retina, enabling high-acuity vision for tasks such as facial recognition and reading. view more

    Research Areas: photoreceptor transplantation, retinal surgery technology and device development, retinal stem cell transplantation, clinical trials in retinal gene therapy
  • The Koliatsos Lab

    Lab Website
    Principal Investigator:
    Vassilis Koliatsos, M.D.
    Pathology

    Founded in the late 1980s, our Lab has been exploring the fundamental mechanisms of neural resp...onses to traumatic and degenerative signals as well as mechanisms of neural repair. Our current interests include: traumatic brain injury and models; mechanisms and treatments of traumatic axonopathies; molecular neuropathology of traumatic brain injury; induced pluripotent stem cells as models of disease. view more

    Research Areas: traumatic brain injuries, pluripotent stem cells, molecular neuropathology, traumatic axonopathies
  • Zack Wang Lab

    Principal Investigator:
    Zack Wang, Ph.D.
    Medicine

    The Wang lab focuses on the signals that direct the differentiation of pluripotent stem cells, ...such as induced-pluripotent stem (iPS) cells, into hematopoietic and cardiovascular cells. Pluripotent stem cells hold great potential for regenerative medicine. Defining the molecular links between differentiation outcomes will provide important information for designing rational methods of stem cell manipulation. view more

    Research Areas: pluripotent stem cells, stem cells, molecular genetics, stem cell biology, gene therapy
  • Zambidis Laboratory

    Principal Investigator:
    Elias Zambidis, M.D., Ph.D.
    Oncology

    The Zambidis Labratory studies the formation of pluripotent stem cells and the subsequent hemat...opoietic, endothelial and cardiac differentiation, as well as the potential therapeutic uses of pluripotent stem cell-derived cells. view more

    Research Areas: stem cells, vasculogenesis, cardiogenesis, hematopoiesis, cancer stem cells, pluripotency
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