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Displaying 1 to 6 of 6 results for sound

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  • Clinical and Computational Auditory neuroscience

    Our laboratory investigates the neural bases of sound processing in the human brain. We combine electrophysiology recordings (intracranial, scalp), behavioral paradigms, and statistical modeling methods to study the cortical dynamics of normal and impaired auditory perception. We are interested in measuring and modeling variability in spatiotemporal cortical response patterns as a function of individual listening abilities and acoustic sound properties. Current studies are investigating the role of high-frequency (>30 Hz) neural oscillations in human auditory perception.

    Research Areas: vestibular disorders

    Lab Website

    Principal Investigator

    Dana Boatman, Ph.D.

    Department

    Neurology

  • Doetzlhofer Laboratory - Center for Sensory Biology

    Auditory hair cells, located in the inner ear cochlea, are critical for our ability to detect sound. Research in Dr. Doetzlhofer's laboratory focuses on ways to identify and characterize the molecular mechanisms of hair cell development in the mammalian auditory system. She is also seeking to identify the molecular roadblocks preventing mammalian hair cell regeneration.

    Research Areas: deafness, auditory system, balance disorders

    Lab Website

    Principal Investigator

    Angelika Doetzlhofer, Ph.D.

    Department

    Neuroscience

  • Dwight Bergles Laboratory

    The Bergles Laboratory studies synaptic physiology, with an emphasis on glutamate transporters and glial involvement in neuronal signaling. We are interested in understanding the mechanisms by which neurons and glial cells interact to support normal communication in the nervous system. The lab studies glutamate transport physiology and function. Because glutamate transporters play a critical role in glutamate homeostasis, understanding the transporters' function is relevant to numerous neurological ailments, including stroke, epilepsy, and neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). Other research in the laboratory focuses on signaling between neurons and glial cells at synapses. Understanding how neurons and cells communicate, may lead to new approaches for stimulating re-myelination following injury or disease. Additional research in the lab examines how a unique form of glia-to-neuron signaling in the cochlea influences auditory system development, whethe...r defects in cell communication lead to certain hereditary forms of hearing impairment, and if similar mechanisms are related to sound-induced tinnitus. view less

    Research Areas: epilepsy, synaptic physiology, ALS, stroke, neuronal signaling, glutamate transport physiology and function, audiology, neuroscience, neurology, nervous system, molecular biology

    Lab Website

    Principal Investigator

    Dwight Bergles, Ph.D.

    Department

    Neuroscience

  • Fuchs Laboratory

    The Fuchs Laboratory uses cellular electrophysiology, immunolabeling and electron microscopy to study synaptic connections between sensory hair cells and neurons in the cochlea. One effort focuses on an unusual cholinergic receptor that mediates efferent inhibition of hair cells, driving discovery of the molecular mechanisms, and offering a target for protection against acoustic trauma. A second topic concerns the small number of unmyelinated "type II" afferent neurons whose synaptic connectivity and response properties argue for a role as the pathway for noxious (too loud) sound. Our studies are motivated by curiosity about fundamental mechanisms, and to provide a foundation for understanding cochlear pathogenesis.

    Research Areas: synaptic connections, immunolabeling, neurons, elecrophysiology, audiology, cellular electrophysiology, hearing loss, electron microscopy, cochlea, cochlear pathogensesis

  • Glowatzki Lab

    Research in the Glowatzki Lab focuses on the auditory system, with a particular focus on synaptic transmission in the inner ear.

    Our lab is using dendritic patch clamp recordings to examine mechanisms of synaptic transmission at this first, critical synapse in the auditory pathway. With this technique, we can diagnose the molecular mechanisms of transmitter release at uniquely high resolution (this is the sole input to each afferent neuron), and relate them directly to the rich knowledge base of auditory signaling by single afferent neurons.

    We study pre- and post-synaptic mechanisms that determine auditory nerve fiber properties. This approach will help to study general principles of synaptic transmission and specifically to identify the molecular substrates for inherited auditory neuropathies and other cochlear dysfunctions.

    Research Areas: synaptic transmission, auditory synapses, inner ear, neurotransmitters, inherited auditory neuropathy, cochlear dysfunctions, otolaryngology, audiology, neuroscience, sound

  • John Matthew Austin Lab

    Research in the John Matthew Austin Lab explores health care performance measures, with a goal of improving patient care by enabling healthcare providers to view data about their performance, track patient outcomes and comply with best care practices. Our lab is currently working to develop performance measures for the ICU part, and we are part of The Leapfrog Group, an annual survey of U.S. hospitals that compares hospital performance on national measures of safety, quality and efficiency. Our research also explores the use of scientifically sound decision-support tools for guiding improvements in healthcare delivery systems.

    Research Areas: health care quality, patient safety, health care performance, patient outcomes, ICU, information technology

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