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Displaying 1 to 4 of 4 results for signaling networks

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  • Heng Zhu Lab

    The Zhu lab is focused on characterizing the activities of large collection of proteins, building signaling networks for better understanding the mechanisms of biological processes, and identifying biomarkers in human diseases and cancers. More specifically, our group is interested in analyzing protein posttranslational modifications, and identifying important components involved in transcription networks and host-pathogen interactions on the proteomics level, and biomarkers in human IBD diseases.

    Research Areas: inflammatory bowel disease, biomarkers, cancer

  • Inoue Lab

    Complexity in signaling networks is often derived from co-opting one set of molecules for multiple operations. Understanding how cells achieve such sophisticated processing using a finite set of molecules within a confined space--what we call the "signaling paradox"--is critical to biology and engineering as well as the emerging field of synthetic biology.

    In the Inoue Lab, we have recently developed a series of chemical-molecular tools that allow for inducible, quick-onset and specific perturbation of various signaling molecules. Using this novel technique in conjunction with fluorescence imaging, microfabricated devices, quantitative analysis and computational modeling, we are dissecting intricate signaling networks.

    In particular, we investigate positive-feedback mechanisms underlying the initiation of neutrophil chemotaxis (known as symmetry breaking), as well as spatio-temporally compartmentalized signaling of Ras and membrane lipids such as phosphoinositides. In parallel,... we also try to understand how cell morphology affects biochemical pathways inside cells. Ultimately, we will generate completely orthogonal machinery in cells to achieve existing, as well as novel, cellular functions. Our synthetic, multidisciplinary approach will elucidate the signaling paradox created by nature. view more

    Research Areas: biochemistry, cell biology, chemotaxis, cancer, signaling paradox, signaling networks, molecular biology, synthetic biology

    Lab Website

    Principal Investigator

    Takanari Inoue, Ph.D.

    Department

    Cell Biology

  • Wilmer Bioinformatics Lab

    Wilmer Bioinformatics has been mainly focused on ocular informatics. Specifically, the group develops and applies bioinformatics approaches to study gene regulation and signaling networks, with particular but not exclusive attention to the mammalian retina. Understanding the molecular basis of tissue specific gene regulation and signaling will contribute to better prevention, diagnosis and treatment of retinal disease.

    Research Areas: retinal gene regulation

    Lab Website

    Principal Investigator

    Jiang Qian, M.S., Ph.D.

    Department

    Ophthalmology

  • Zhu Lab

    The Zhu lab is focused on characterizing the activities of large collection of proteins, building signaling networks for better understanding the mechanisms of biological processes, and identifying biomarkers in human diseases and cancers.

    More specifically, our group is interested in analyzing protein posttranslational modifications, and identifying important components involved in transcription networks and host-pathogen interactions on the proteomics level, and biomarkers in human IBD diseases.

    Research Areas: proteomics, biomarkers, cancer, genomics, protein chip, signaling networks

    Principal Investigator

    Heng Zhu, Ph.D.

    Department

    Pharmacology and Molecular Sciences

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