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• Linda Smith-Resar Lab

  The Linda Smith-Resar Lab primarily investigates hematologic malignancy and molecular mechanisms that lead to cancer as well as sickle cell anemia. Recent studies suggest that education is an important and effective component of a patient blood management program and that computerized provider order entry algorithms may serve to maintain compliance with evidence-based transfusion guidelines. Another recent study indicated that colonic epithelial cells undergo metabolic reprogramming during their evolution to colorectal cancer, and the distinct metabolites could serve as diagnostic tools or potential targets in therapy or primary prevention.

  Research Areas: blood disorders, sickle cell diseases, blood management programs, hematologic malignancies

  Lab Website

  

  Principal Investigator

  Linda Smith Resar, M.D.

  Department

  Medicine
  

• Rakhi Naik Lab

  The Rakhi Naik Lab studies sickle cell disease. We focus on complications related to the disease, including chronic kidney disease and venous thromboembolism. By defining the risks and factors for diseases related to the sickle cell trait, we hope to improve genetic counseling and screening and treatment recommendations. Other research in the lab examines the epidemiology and unique mechanisms of thrombosis in patients with hemoglobin disorders. Specifically, we are trying to identify mechanisms of hypercoagulability and develop treatments for patients with hemoglobinopathies.

  Research Areas: epidemiology, sickle cell diseases, kidney diseases, venous thromboembolism, hemoglobin disorders, genetic counseling

  

  Principal Investigator

  Rakhi Naik, M.D., M.H.S.

  Department

  Medicine
  

• Sophie Lanzkron Lab

  Work in the Sophie Lanzkron Lab is focused on understanding the barriers to care for adults with sickle cell disease. Our research has shown that despite the approval of hydroxyurea treatment predicted to decrease hospitalizations for sickle cell disease patients' the cost of care has increased significantly in recent years. Research is ongoing to identify the factors that limit access to care for this population.

  Research Areas: sickle cell diseases, patient-centered health care, hydroxyurea, health services research

  

  Principal Investigator

  Sophie Lanzkron, M.D., M.H.S.

  Department

  Medicine
  

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