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Displaying 1 to 3 of 3 results for sepsis

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  • Li Gao Lab

    The Li Gao Lab researches functional genomics, molecular genetics and epigenetics of complex cardiopulmonary and allergic diseases, with a focus on translational research applying fundamental genetic insight into the clinical setting. Current research includes implementation of high-throughput technologies in the fields of genome-wide association studies (GWAS), massively parallel sequencing, gene expression analysis, epigenetic mapping and integrative genomics in ongoing research of complex lung diseases and allergic diseases including asthma, atopic dermatitis (AD), pulmonary arterial hypertension, COPD, sepsis and acute lung injury/ARDS; and epigenetic contributions to pulmonary arterial hypertension associated with systemic sclerosis.

    Research Areas: pulmonary arterial hypertension, molecular genetics, cardiopulmonary diseases, asthma, epigenetics, complex lung disease, allergies, genomics, COPD, atopic dermatitis

    Principal Investigator

    Li Gao, M.D., Ph.D.

    Department

    Medicine

  • Robert Stevens Lab

    The Robert Stevens Lab seeks to generate a comprehensive anatomical and functional map of neural injury and repair following incidents such as trauma, stroke, anoxia and sepsis. Several projects have evaluated the relationship between critical illness and central or peripheral nervous system dysfunction. Ongoing projects deploy quantitative brain mapping to probe recovery of consciousness and cognitive function in patients who have experienced acute neurologic insults from trauma, stroke, cardiac arrest and sepsis.

    Research Areas: anoxia, stroke, trauma, sepsis, neural injury

    Lab Website

    Principal Investigator

    Robert Stevens, M.D.

    Department

    Medicine

  • The Hackam Lab for Pediatric Surgical, Translational and Regenerative Medicine

    David Hackam’s laboratory focuses on necrotizing enterocolitis (NEC), a devastating disease of premature infants and the leading cause of death and disability from gastrointestinal disease in newborns.

    The disease strikes acutely and without warning, causing sudden death of the small and large intestines. In severe cases, tiny patients with the disease are either dying or dead from overwhelming sepsis within 24 hours. Surgical treatment to remove most of the affected gut results in lifelong short gut (short bowel) syndrome.

    The Hackam Lab has identified a critical role for the innate immune receptor toll-like receptor 4 (TLR4) in the pathogenesis of necrotizing enterocolitis. The lab has shown that TLR4 regulates the development of the disease by tipping the balance between injury and repair in the stressed intestine of the premature infant. Developing an Artificial Intestine A key goal is to create, in the laboratory, new intestines made from patients’ own cells, which can then ...be implanted into the patient to restore normal digestive function. This innovative design could transform child development and quality of life in necrotizing enterocolitis survivors without the risks of conventional donor transplant. view more

    Research Areas: necrotizing enterocolitis, gut inflammation, stem cell biology, premature infants, TLR4

    Lab Website

    Principal Investigator

    David Hackam, M.D., Ph.D.

    Department

    Pediatrics
    Surgery

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