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Research Lab Results for scleroderma

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  • Allan Gelber Lab

    The Allan Gelber Lab conducts research on the clinical epidemiology of rheumatic disorders. Our... recent studies have explored topics that include the predicting factors of prevalent and incident gout; cardiovascular disease burden and risk in patients with rheumatoid arthritis; autoantibodies in both primary and secondary SjogrenÕs syndrome; and predictors of outcomes in patients with scleroderma. In addition, we have a long-standing interest in the ways in which racial differences affect disease manifestations in relation to rheumatic disorders. view more

    Research Areas: rheumatology, gout, Sjogren's syndrome, scleroderma, race, health disparities, rheumatoid arthritis
  • Ami Shah Lab

    Lab Website
    Principal Investigator:
    Ami Shah, M.D.
    Medicine

    Researchers in the Ami Shah Lab study scleroderma and Raynaud’s phenomenon. We examine the rela...tionship between cancer and scleroderma, with a focus on how and if cancer causes scleroderma to develop in some patients. We are currently conducting clinical research to study ways to detect cardiopulmonary complications in patients with scleroderma, biological and imaging markers of Raynaud’s phenomenon, and drugs that improve aspects of scleroderma. view more

    Research Areas: Raynaud's phenomenon, cancer, scleroderma, drugs, cardiovascular diseases
  • Antony Rosen Lab

    Principal Investigator:
    Antony Rosen, M.B.Ch.B., M.S.
    Medicine

    Research in the Antony Rosen Lab investigates the mechanisms shared by the autoimmune rheumatic... diseases such as lupus, myositis, rheumatoid arthritis, scleroderma and SjogrenÕs syndrome. We focus on the fate of autoantigens in target cells during various circumstances, such as viral infection, relevant immune effector pathways and exposure to ultraviolet radiation. Our recent research has sought to define the traits of autoantibodies that enable them to induce cellular or molecular dysfunction. We also work to better understand the mechanisms that form the striking connections between autoimmunity and cancer. view more

    Research Areas: myositis, lupus, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases, rheumatoid arthritis
  • Fredrick Wigley Lab

    Principal Investigator:
    Fredrick Wigley, M.D.
    Medicine

    The Frederick Wigley Lab is interested in the signs, symptoms and causes of scleroderma. We are... testing new treatments for RaynaudÕs phenomenon and scleroderma. Understanding the treatment approach to Raynaud's phenomenon and associated ischemia and how to prevent digital ulcers is important for clinicians caring for these patients. Work in our lab has provided guidance in the management of Raynaud's phenomenon and digital ischemic ulcers, including options for the practical pharmacologic and nonpharmacologic interventions. view more

    Research Areas: Raynaud's phenomenon, rheumatology, scleroderma, autoimmune diseases, systemic sclerosis, ischemic ulcers
  • Laura Hummers Lab

    Lab Website
    Principal Investigator:
    Laura Hummers, M.D.
    Medicine

    The Laura Hummers Lab participates in a number of clinical trials and clinical investigations a...t the Scleroderma Center at Johns Hopkins. We have a particular interest in the predictors of outcomes in scleroderma. We’ve established a prospective cohort of 300 scleroderma patients to identify incident vascular outcomes in the hopes of identifying new biomarkers for disease development and progression. view more

    Research Areas: rheumatology, biomarkers, scleroderma
  • Livia Casciola-Rosen Lab

    Principal Investigator:
    Livia Casciola-Rosen, Ph.D.
    Medicine

    Work in the Livia Casciola-Rosen Lab explores the shared mechanisms present in autoimmune rheum...atic diseases, specifically scleroderma, Sjogren's syndrome and myositis. We use disease-specific autoantibodies to identify the factors that cause the autoimmune response in such diseases. Our current research involves identifying the antigen targets of autoimmune diseases, investigating the autoantigens targeted in cancers associated with rheumatic diseases and finding unique clinical biomarkers, such as the anti-HMGCR antibody specificity. view more

    Research Areas: autoantibodies, myositis, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases
  • Paul M. Hassoun Lab

    Principal Investigator:
    Paul Hassoun, M.D.
    Medicine

    The Paul M. Hassoun Lab leads research on the source and treatment of pulmonary arterial hypert...ension in scleroderma. view more

    Research Areas: pulmonary arterial hypertension, scleroderma, hypertension, lung disease
  • Rachel Damico Lab

    Principal Investigator:
    Rachel Damico, M.D., Ph.D.
    Medicine

    Work in the Rachel Damico Lab explores topics within the fields of vascular biology and pulmona...ry medicine, with a focus on acute lung injury and apoptosis in lung diseases. Our studies have included examining idiopathic and scleroderma-associated pulmonary arterial hypertension, vascular receptor autoantibodies, and the link between inflammation and the Warburg phenomenon in patients with pulmonary arterial hypertension. We have also researched the inhibitory factor of macrophage migration and its governing of endothelial cell sensitivity to LPS-induced apoptosis. view more

    Research Areas: critical care medicine, acute lung injury, lung disease, vascular biology, apoptosis
  • Robert Wise Lab

    Principal Investigator:
    Robert Wise, M.D.
    Medicine

    The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD).... We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma. view more

    Research Areas: critical care medicine, emphysema, scleroderma, pulmonary medicine, asthma, lung-volume reduction surgery, COPD
  • Stephen Mathai Lab

    Principal Investigator:
    Stephen Mathai, M.D., M.H.S.
    Medicine

    The Stephen Mathai Lab focuses its research on pulmonary medicine. We're particularly intereste...d in scleroderma-associated pulmonary hypertension, pulmonary complications of connective tissue disease, idiopathic pulmonary fibrosis and pulmonary hypertension. view more

    Research Areas: scleroderma, pulmonary medicine, hypertension, pulmonary fibrosis, connective tissue disease
  • Tsion Abdi Lab

    Principal Investigator:
    Tsion Abdi, M.D., M.P.H.
    Medicine

    The Tsion Abdi Lab performs clinical research on Scleroderma Bowel Disease and Inflammatory Bow...el Disease. view more

    Research Areas: inflammatory bowel disease, Scleroderma Bowel Disease
  • Zsuzsanna McMahan Lab

    Lab Website
    Principal Investigator:
    Zsuzsanna McMahan, M.D., M.H.S.
    Medicine

    The Zsuzsanna McMahan Lab conducts translational research that seeks to identify the novel anti...gens in scleroderma and to define the target tissue in this disease. We are conducting two active clinical research trials, including one that studies skin biopsy specimens as biomarkers of scleroderma and the response to mycophenolate mofetil (MMF or Cellcept). The other study is a gastrointestinal involvement registry that follows patients who are experiencing GERD, small bowel bacterial overgrowth, constipation, fecal incontinence and gastroparesis to see if there is improvement in symptoms after a change in treatment is implemented. view more

    Research Areas: gastrointestinal system, rheumatology, biomarkers, scleroderma, antigens, mycophenolate mofetil
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