Research Lab Results for rheumatoid arthritis
Allan Gelber LabPrincipal Investigator:
Allan Gelber, M.D., Ph.D., M.P.H.
The Allan Gelber Lab conducts research on the clinical epidemiology of rheumatic disorders. Our... recent studies have explored topics that include the predicting factors of prevalent and incident gout; cardiovascular disease burden and risk in patients with rheumatoid arthritis; autoantibodies in both primary and secondary SjogrenÕs syndrome; and predictors of outcomes in patients with scleroderma. In addition, we have a long-standing interest in the ways in which racial differences affect disease manifestations in relation to rheumatic disorders. view moreResearch Areas: rheumatology, gout, Sjogren's syndrome, scleroderma, race, health disparities, rheumatoid arthritis
Ana-Marie Orbai LabLab WebsitePrincipal Investigator:
Ana-Maria Orbai, M.D., M.H.S.
The Ana-Marie Orbai Lab focuses on inflammatory arthritis. Current clinical research projects i...n the lab examine patient symptoms and experiences in rheumatic diseases and inflammatory arthritis. We focus on stiffness in rheumatoid arthritis and patient-reported outcomes. Previous research in the lab focused on systemic lupus erythemaous (SLE). view moreResearch Areas: autoimmune rheumatic diseases, arthritis, rheumatoid arthritis
Antony Rosen LabPrincipal Investigator:
Antony Rosen, M.B.Ch.B., M.S.
Research in the Antony Rosen Lab investigates the mechanisms shared by the autoimmune rheumatic... diseases such as lupus, myositis, rheumatoid arthritis, scleroderma and SjogrenÕs syndrome. We focus on the fate of autoantigens in target cells during various circumstances, such as viral infection, relevant immune effector pathways and exposure to ultraviolet radiation. Our recent research has sought to define the traits of autoantibodies that enable them to induce cellular or molecular dysfunction. We also work to better understand the mechanisms that form the striking connections between autoimmunity and cancer. view moreResearch Areas: myositis, lupus, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases, rheumatoid arthritis
Clifton O. Bingham III LabPrincipal Investigator:
Clifton O. Bingham, M.D.
Research in the Clifton O. Bingham III Lab focuses on defining clinical and biochemical disease... phenotypes related to therapeutic responses in rheumatoid arthritis and osteoarthritis; developing rational clinical trial designs to test new treatments; improving patient-reported outcome measures; evaluating novel imaging modalities for arthritis; and examining the role of oral health in inflammatory arthritis. view moreResearch Areas: biochemistry, imaging, osteoarthritis, clinical trials, inflammation, oral health, rheumatoid arthritis
Erika Darrah LabLab WebsitePrincipal Investigator:
Erika Darrah, Ph.D.
The Erika Darrah Lab is primarily interested in the mechanisms underlying the development and p...rogression of autoimmunity in rheumatoid arthritis (RA), with a particular focus on the peptidyl arginine deiminase (PAD) enzymes. We’re focused on understanding the development of PAD4-activating autoantibodies over time and how they contribute to the development of erosive disease. Studies are underway to determine if the newly discovered antibody is mimicking a naturally occurring PAD4 binding partner and to identify potentially pro-inflammatory effects of citrullinated proteins on effector cells of the immune system. view moreResearch Areas: antibodies, autoimmune diseases, peptidylarginine deiminase enzymes, rheumatoid arthritis
Felipe Andrade LaboratoryPrincipal Investigator:
Felipe Andrade, M.D., Ph.D.
Research in the laboratory of Felipe Andrade, M.D., Ph.D., focuses on the mechanisms of systemi...c autoimmune diseases, particularly as they relate to the role of cytotoxic granule proteases in autoimmunity and viral clearance, mechanisms of autoantigen citrullination and pathways that control immune effector functions in autoimmune diseases. We currently focus on two principal areas: (1) defining the mechanisms that generate citrullinated autoantigens in vivo in rheumatoid arthritis and (2) understanding the pathways that control the activity of the peptidylarginine deiminase (PAD) enzymes in human neutrophils. view moreResearch Areas: autoantigens, autoimmune diseases, cytotoxic granule proteases, peptidylarginine deiminase enzymes, rheumatoid arthritis
The Cihakova LabLab WebsitePrincipal Investigator:
Daniela Cihakova, M.D., Ph.D.
The Cihakova research laboratory is an immunology laboratory dedicated to the investigation of ...autoimmune diseases. Our most active research is focused on myocarditis and dilated cardiomyopathy. We expanded our interest in inflammatory heart diseases to include the study of immune mechanisms driving pericarditis and myocardial infarction. In addition, we are interested in the pathogenesis of a broad range of autoimmune diseases such as, Sjogren's syndrome, congenital complete heart block, and APECED (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy). Through several collaborative projects we also investigate rheumatoid arthritis and the immune components of schizophrenia. view moreResearch Areas: schizophrenia, autoimmune diseases, myocardial infarction, cardiomyopathy