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Displaying 1 to 12 of 12 results for renal

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  • C. John Sperati Lab

    Research in the C. John Sperati Lab focuses on hypertension and kidney diseases. Topics of recent studies include novel treatments for these conditions, secondary hypertension and the genetic epidemiology of chronic kidney disease. Within the area of hypertension, we are particularly interested fibromuscular dysplasia, hyperaldosteronism, atherosclerotic renal arterial disease and genetic hypertensive syndromes.

    Research Areas: kidney diseases, fibromuscular dysplasia, hypertension, hyperaldosteronism, atherosclerosis

    Principal Investigator

    C. John Sperati, M.D., M.H.S.

    Department

    Medicine

  • Chirag Parikh Lab

    Dr. Parikh's research focuses on the translation and validation of novel biomarkers for the diagnosis and prognosis of acute kidney injury. Progress in kidney diseases has been hamstrung by significant heterogeneity within the current disease definitions, which are largely based on serum creatinine. Dr. Parikh's research has addressed this critical challenge by developing biomarkers of renal tubular injury, repair, and inflammation to dissect this heterogeneity. He has assembled multicenter longitudinal prospective cohorts for translational research studies across several clinical settings of acute kidney injury and chronic kidney disease for the efficient translation of novel biomarkers.

    His research is dedicated to the process of applying discoveries generated in the laboratory and in preclinical experiments, the development of clinical studies, and the design of clinical trials. Dr. Parikh's studies have refined the clinical definition in perioperative acute kidney injury and hep...atorenal syndrome, developed strategies to reduce kidney discard in deceased donor transplantation, and advanced regulatory approvals of kidney injury biomarkers. He has also developed biomarkers to identify rapid progressors of early diabetic kidney disease before derangements in serum creatinine. Dr. Parikh's research goal is to translate our understanding of pathophysiological mechanisms into clinical practice and improve the outcomes in patients with kidney disease.

    Dr. Parikh has also been the recipient of numerous honors, including the 2017 Young Investigator Award from the American Society of Nephrology.
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    Research Areas: acute kidney injury, biomarkers, Kidney Transplantation, chronic kidney disease

    Lab Website

    Principal Investigator

    Chirag Parikh, M.B.B.S., Ph.D.

    Department

    Medicine

  • Deidra Crews Lab

    Research in the Deidra Crews Lab focuses on health disparities in chronic kidney disease. We have studied how social determinants of health, such as poverty and healthful food access, affect disparities in kidney disease outcomes. Our research on end-stage renal disease includes studies of the best timing and environment to initiate dialysis among vulnerable populations.

    Research Areas: poverty, chronic kidney disease, health disparities

    Principal Investigator

    Deidra Crews, M.D., Sc.M.

    Department

    Medicine

  • Duvuru Geetha Lab

    Research in the Duvuru Geetha Lab focuses on renal diseases in patients with systemic vasculitis as well as BK virus nephropathy in patients who have undergone renal transplant. Our studies include clinical trials on the effectiveness of rituximab versus cyclosporine in treating idiopathic membranous nephropathy and a multinational study of belimumab with azathioprine for maintaining remission of granulomatosis with polyangiitis and microscopic polyangiitis. We also have conducted research on the treatment of ANCA vasculitis, particularly in kidney transplant patients.

    Research Areas: granulomatosis with polyangiitis, kidney diseases, vasculitis, kidney transplants, Glomerulonephritis, nephrology

    Principal Investigator

    Duvuru Geetha, M.B.B.S.

    Department

    Medicine

  • J. Hunter Young Lab

    Research in the J. Hunter Young Lab focuses on the genetic epidemiology and physiology of cardiovascular disease and its risk factors, especially hypertension, diabetes and obesity. Current activities include an observational study of hypertension among African Americans; a genetic epidemiology study of worldwide cardiovascular disease susceptibility patterns; and several population-based observational studies of cardiovascular and renal disease. A recent focus group study found that changes in housing and city policies might lead to improved environmental health conditions for public housing residents.

    Research Areas: epidemiology, kidney diseases, obesity, hypertension, diabetes, genomics, physiology, cardiovascular diseases

    Principal Investigator

    Jeffery Young, M.D., M.H.S.

    Department

    Medicine

  • Mohamed Atta Lab

    Research in the Mohamed Atta Lab focuses on kidney diseases in patients with HIV. We recently reviewed the published nephrotoxic effects of newer antiviral therapies for HIV and hepatitis C, specifically looking at the role of epithelial organic transporters in explaining renal toxicities. We also examined the relationship between the APOL1 genotype and renal histology among black patients with HIV who had undergone kidney biopsies.

    Research Areas: kidney diseases, HIV, hepatitis C

    Principal Investigator

    Mohamed Atta, M.B.B.Ch., M.D., M.P.H.

    Department

    Medicine

  • Morgan Grams Lab

    Research in the Morgan Grams Lab focuses on preventing and improving the complications associated with chronic kidney disease. Recent work includes examining the racial differences in and prognostic value of biomarkers of hyperglycemia. We’ve also developed an online tool to help identify living kidney donor candidates. The tool assesses the long-term risk of end-stage renal disease (ESRD) by weighing a variety of factors.

    Research Areas: organ donors, hyperglycemia, biomarkers, chronic kidney disease, health disparities

    Principal Investigator

    Morgan Grams, M.D., M.H.S., Ph.D.

    Department

    Medicine

  • Pluznick Lab

    The Pluznick Lab is interested in the role that chemosensation plays in regulating physiological processes, particularly in the kidney and the cardiovascular system. We have found that sensory receptors (olfactory receptors, taste receptors, and other G-protein coupled receptors) are expressed in the kidney and in blood vessels, and that individual receptors play functional roles in whole-animal physiology. We are currently working to identify the full complement of sensory receptors found in the kidney, and are working to understand the role that each receptor plays in whole-animal physiology by using a variety of in vitro (receptor localization, ligand screening) and in vivo (whole-animal physiology) techniques.

    Research Areas: sensory receptors, cardiovascular, physiology, chemosensation, renal

    Lab Website

    Principal Investigator

    Jennifer Pluznick, Ph.D.

    Department

    Physiology

  • Raquel Greer Lab

    Work in the Raquel Greer Lab focuses primarily on health disparities in chronic kidney disease. Our most recent research explored the challenges perceived by primary care providers in educating patients about chronic kidney disease as well as physicians’ views on barriers to adequate preparation of patients for renal replacement therapy. We also are interested in examining how clinical-patient communication can impact quality of care in the primary care setting.

    Research Areas: primary care, kidney diseases, patient-provider relationships

    Principal Investigator

    Raquel Greer, M.D., M.H.S.

    Department

    Medicine

  • Sharon Turban Lab

    Research in the Sharon Turban Lab focuses on the effects of sodium and potassium on blood pressure and on kidney function. We lead the Chronic Kidney Disease-Potassium (CKD-K) clinical trial, funded by American Heart Association, which examines the benefits and safety of two levels of potassium intake in patients with kidney disease. Other research includes the Chronic Renal Insufficiency Cohort (CRIC) study, which aims to improve the understanding of chronic kidney disease and related cardiovascular illness.

    Research Areas: sodium, kidney diseases, potassium, chronic kidney disease, blood pressure

    Principal Investigator

    Sharon Turban, M.D.

    Department

    Medicine

  • Stephen Sozio Lab

    Researchers in the Stephen Sozio Lab study chronic kidney disease epidemiology, determine risk factors for stroke and cognitive impairment in patients with kidney disease, and perform comparative effectiveness research in patients with ESRD.

    Research Areas: end stage renal disease (ESRD), epidemiology, kidney diseases, stroke

    Principal Investigator

    Stephen Sozio, M.D.

    Department

    Medicine

  • Todd Dorman Lab

    Research conducted in the Todd Dorman Lab examines the use of informatics in intensive care settings as it relates to remote patient monitoring, safety and management strategies. Specific areas of interest include the surgical stress response; aminoglycoside antibiotics; fungal infections; renal failure; pharmacokinetic models of drug administration; and ICU triage and its impact on disaster preparedness.

    Research Areas: fungal infections, patient safety, informatics, disaster preparedness, aminoglycoside antibiotics, surgical stress response, ICU, patient monitoring

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