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Research Lab Results for renal

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  • C. John Sperati Lab

    Principal Investigator:
    C. John Sperati, M.D., M.H.S.
    Medicine

    Dr. Sperati’s group focuses on complement mediated kidney disorders, glomerular disease, and re...nal arterial disease secondary to fibromuscular dysplasia. His team has a particular interest in thrombotic microangiopathies involving the complement system. view more

    Research Areas: kidney diseases, fibromuscular dysplasia, hypertension, hyperaldosteronism, atherosclerosis
  • Center for Epithelial Disorders

    Principal Investigator:
    Mark Donowitz, M.D.
    Medicine

    The Johns Hopkins Center for Epithelial Disorders focuses on research into the physiology and p...athophysiology of epithelial cells (cells that line the cavities and interior surfaces of the body) of the gastrointestinal (GI) tract, liver, pancreas and kidney. Specifically, the center’s research seeks to:

    -Understand the mechanisms regulating the activity of transport proteins (including channels) of epithelial cells
    Characterize the mechanisms by which polarity of epithelial cells are maintained
    -Investigate the mechanisms controlling transcription of epithelial-specific genes
    Understand the pathophysiological basis of GI and renal diseases that involve the preceding three components
    -The center also provides a framework for training fellows in gastroenterology and hepatology to become independent investigators.

    The center is funded primarily through individual investigator-initiated extramural research grant support from the National Institutes of Health (NIH) as well as multi-investigator grants including RO1, PO1, UO1 and R24.
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    Research Areas: gastroenterology, epithelial cells
  • Chirag Parikh Lab

    Lab Website
    Principal Investigator:
    Chirag Parikh, M.B.B.S., Ph.D.
    Medicine

    Dr. Parikh's research focuses on the translation and validation of novel biomarkers for the dia...gnosis and prognosis of acute kidney injury. Progress in kidney diseases has been hamstrung by significant heterogeneity within the current disease definitions, which are largely based on serum creatinine. Dr. Parikh's research has addressed this critical challenge by developing biomarkers of renal tubular injury, repair, and inflammation to dissect this heterogeneity. He has assembled multicenter longitudinal prospective cohorts for translational research studies across several clinical settings of acute kidney injury and chronic kidney disease for the efficient translation of novel biomarkers.



    His research is dedicated to the process of applying discoveries generated in the laboratory and in preclinical experiments, the development of clinical studies, and the design of clinical trials. Dr. Parikh's studies have refined the clinical definition in perioperative acute kidney injury and hepatorenal syndrome, developed strategies to reduce kidney discard in deceased donor transplantation, and advanced regulatory approvals of kidney injury biomarkers. He has also developed biomarkers to identify rapid progressors of early diabetic kidney disease before derangements in serum creatinine. Dr. Parikh's research goal is to translate our understanding of pathophysiological mechanisms into clinical practice and improve the outcomes in patients with kidney disease.



    Dr. Parikh has also been the recipient of numerous honors, including the 2017 Young Investigator Award from the American Society of Nephrology.
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    Research Areas: acute kidney injury, biomarkers, Kidney Transplantation, chronic kidney disease
  • Deidra Crews Lab

    Principal Investigator:
    Deidra Crews, M.D.
    Medicine

    Dr. Crews’ team focuses on health disparities in chronic kidney disease. We have studied how so...cial determinants of health, such as poverty and healthful food access, affect disparities in kidney disease outcomes. Our research on end-stage renal disease includes studies of the best timing and environment to initiate dialysis among vulnerable populations. view more

    Research Areas: poverty, chronic kidney disease, health disparities
  • Duvuru Geetha Lab

    Principal Investigator:
    Duvuru Geetha, M.B.B.S.
    Medicine

    Dr. Geetha’s team focuses on renal diseases in patients with systemic vasculitis as well as BK ...virus nephropathy in patients who have undergone renal transplant. Our studies include clinical trials on the effectiveness of rituximab versus cyclosporine in treating idiopathic membranous nephropathy and a multinational study of belimumab with azathioprine for maintaining remission of granulomatosis with polyangiitis and microscopic polyangiitis. We also have conducted research on the treatment of ANCA vasculitis, particularly in kidney transplant patients. view more

    Research Areas: granulomatosis with polyangiitis, kidney diseases, vasculitis, kidney transplants, Glomerulonephritis, nephrology
  • J. Hunter Young Lab

    Principal Investigator:
    Jeffery Young, M.D., M.H.S.
    Medicine

    Research in the J. Hunter Young Lab focuses on the genetic epidemiology and physiology of cardi...ovascular disease and its risk factors, especially hypertension, diabetes and obesity. Current activities include an observational study of hypertension among African Americans; a genetic epidemiology study of worldwide cardiovascular disease susceptibility patterns; and several population-based observational studies of cardiovascular and renal disease. A recent focus group study found that changes in housing and city policies might lead to improved environmental health conditions for public housing residents. view more

    Research Areas: epidemiology, kidney diseases, obesity, hypertension, diabetes, genomics, physiology, cardiovascular diseases
  • Stephen Sozio Lab

    Principal Investigator:
    Stephen Sozio, M.D.
    Medicine

    Dr. Sozio’s research focuses on 1) Clinical research related to chronic kidney disease and end ...stage renal disease, and 2) Educational research in undergraduate and graduate medical education.



    The Sozio lab pursues work related to stroke, cognitive impairment, manifestations of kidney disease, and systematic reviews on clinical topics, and collaborates on multiple projects with other key investigators. In particular, Dr. Sozio has been an active investigator in the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study, Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) Study, Chronic Renal Insufficiency Cohort (CRIC) Study, and work funded through the Agency for Healthcare Research and Quality (AHRQ) and Johns Hopkins Evidence-Based Practice Center. In addition, the Sozio lab performs studies at the UME and GME levels, investing in understanding learners’ mentorship, research, and transitional experiences.
    view more

    Research Areas: end stage renal disease (ESRD), epidemiology, kidney diseases, stroke
  • Todd Dorman Lab

    Research conducted in the Todd Dorman Lab examines the use of informatics in intensive care set...tings as it relates to remote patient monitoring, safety and management strategies. Specific areas of interest include the surgical stress response; aminoglycoside antibiotics; fungal infections; renal failure; pharmacokinetic models of drug administration; and ICU triage and its impact on disaster preparedness. view more

    Research Areas: fungal infections, patient safety, informatics, disaster preparedness, aminoglycoside antibiotics, surgical stress response, ICU, patient monitoring
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