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Research Lab Results for regenerative medicine

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  • Cardiovascular Stem Cell Program

    Lab Website
    Principal Investigator:
    Chulan Kwon, Ph.D., M.S.
    Medicine

    The research program aims to advance cardiovascular biology and medicine by focusing on pluripo...tent stem cell-based modeling and therapy and by nurturing future leaders in regenerative medicine. view more

    Research Areas: cardiac, stem cells, cardiology, regenerative medicine
  • Elisseeff Lab

    Lab Website
    Principal Investigator:
    Jennifer Elisseeff, Ph.D.
    Ophthalmology

    The mission of the Elisseeff Lab is to engineer technologies to repair lost tissues. We aim to ...bridge academic research and technology discovery to treat patients and address clinically relevant challenges related to tissue engineering. To accomplish this goal we are developing and enabling materials, studying biomaterial structure-function relationships and investigating mechanisms of tissue development to practically rebuild tissues. The general approach of tissue engineering is to place cells on a biomaterial scaffold that is designed to provide the appropriate signals to promote tissue development and ultimately restore normal tissue function in vivo. Understanding mechanisms of cellular interactions (both cell-cell and cell-material) and tissue development on scaffolds is critical to advancement of the field, particularly in applications employing stem cells. Translation of technologies to tissue-specific sites and diseased environments is key to better design, understanding, and ultimately efficacy of tissue repair strategies. We desire to translate clinically practical strategies, in the form of biomaterials/medical devices, to guide and enhance the body's natural capacity for repair. To accomplish the interdisciplinary challenge of regenerative medicine research, we maintain a synergistic balance of basic and applied/translational research. view more

    Research Areas: stem cells, biomedical engineering, tissues
  • Kunisaki Lab

    Principal Investigator:
    Shaun Kunisaki, M.D., M.Sc.
    Surgery

    The Kunisaki lab is a R01-funded regenerative medicine group within the Division of General ...Pediatric Surgery at Johns Hopkins that works at the interface of stem cells, mechanobiology, and materials science. We seek to understand how biomaterials and mechanical forces affect developing tissues relevant to pediatric surgical disorders. To accomplish these aims, we take a developmental biology approach using induced pluripotent stem cells and other progenitor cell populations to understand the cellular and molecular mechanisms by which fetal organs develop in disease.


    Our lab projects can be broadly divided into three major areas: 1) fetal spinal cord regeneration 2) fetal lung development 3) esophageal regeneration


    Lab members: Juan Biancotti, PhD (lab manager); Lynn Zhou, PhD (postdoc), Shelby Sferra, MD, MPH (postdoc); Annalise Penikis, MD (postdoc)


    Recent publications:
    Kunisaki SM, Jiang G, Biancotti JC, Ho KKY, Dye BR, Liu AP, Spence JR. Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of congenital diaphragmatic hernia fetal lung. Stem Cells Translational Medicine 2021, PMID: 32949227


    Biancotti JC, Walker KA, Jiang G, Di Bernardo J, Shea LD, Kunisaki SM. Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in an ex vivo model of prenatal spina bifida repair. Journal of Tissue Engineering 2020, PMID: 32782773.


    Kunisaki SM. Amniotic fluid stem cells for the treatment of surgical disorders in the fetus and neonate. Stem Cells Translational Medicine 2018, 7:767-773

    view more

    Research Areas: fetal therapy, stem cells, pediatric surgery, tissue engineering, congenital diaphragmatic hernia, myelomeningocele
  • Zack Wang Lab

    Principal Investigator:
    Zack Wang, Ph.D.
    Medicine

    The Wang lab focuses on the signals that direct the differentiation of pluripotent stem cells, ...such as induced-pluripotent stem (iPS) cells, into hematopoietic and cardiovascular cells. Pluripotent stem cells hold great potential for regenerative medicine. Defining the molecular links between differentiation outcomes will provide important information for designing rational methods of stem cell manipulation. view more

    Research Areas: pluripotent stem cells, stem cells, molecular genetics, stem cell biology, gene therapy
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