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Research Lab Results for proteins

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  • Solomon Snyder Laboratory

    Lab Website

    Information processing in the brain reflects communication among neurons via neurotransmitters.... The Solomon Snyder Laboratory studies diverse signaling systems including those of neurotransmitters and second messengers as well as the actions of drugs upon these processes. We are interested in atypical neurotransmitters such as nitric oxide (NO), carbon monoxide (CO), and the D-isomers of certain amino acids, specifically D-serine and D-aspartate. Our discoveries are leading to a better understanding of how certain drugs for Parkinson's disease and Hungtington's disease interact with cells and proteins. Understanding how other second messengers work is giving us insight into anti-cancer therapies. view more

    Research Areas: Huntington's disease, amino acids, neurotransmitters, brain, cancer, nitric oxide, drugs, carbon monoxide, Parkinson's disease, nervous system
  • Steven Claypool Lab

    Lab Website
    Principal Investigator:
    Steven Claypool, Ph.D.
    Physiology

    Research in the Claypool Lab is focused on defining how lipids and membrane proteins interact t...o establish and maintain normal mitochondrial function and how derangements in this complex relationship result in pathophysiology. We have demonstrated that yeast lacking tafazzin recapitulates all of the phospholipid abnormalities observed in human patients and many of the mitochondrial defects.

    Another major project in our lab focuses on the mitochondrial ADP/ATP carrier that is required for oxidative phosphorylation. Researchers are studying how these novel interactions help establish normal mitochondrial function, the biochemical details of these associations, and whether disturbances in these assemblies can contribute to mitochondrial dysfunction.
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    Research Areas: biochemistry, proteomics, lipids, yeast, mitochondria, oxidative phosphorylation
  • Susan Michaelis Lab

    Principal Investigator:
    Susan Michaelis, Ph.D.
    Cell Biology

    The Michaelis Laboratory's research goal is to dissect fundamental cellular processes relevant ...to human health and disease, using yeast and mammalian cell biology, biochemistry and high-throughput genomic approaches. Our team studies the cell biology of lamin A and its role in the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Other research focuses on the core cellular machinery involved in recognition of misfolded proteins. Understanding cellular protein quality control machinery will ultimately help researchers devise treatments for protein misfolding diseases in which degradation is too efficient or not enough. view more

    Research Areas: biochemistry, cell biology, protein folding, lamin A, aging, genomics, Hutchinson-Gilford progeria syndrome, yeast
  • Tamara O'Connor Lab

    The O'Connor Lab studies the molecular basis of infectious disease using Legionella pneumophila... pathogenesis as a model system.

    We are looking at the network of molecular interactions acting at the host-pathogen interface. Specifically, we use L. pneumophila pathogenesis to examine the numerous mechanisms by which an intracellular bacterial pathogen can establish infection, how it exploits host cell machinery to accomplish this, and how individual proteins and their component pathways coordinately contribute to disease.

    We are also studying the role of environmental hosts in the evolution of human pathogens. Using genetics and functional genomics, we compare and contrast the repertoires of virulence proteins required for growth in a broad assortment of hosts, how the network of molecular interactions differs between hosts, and the mechanisms by which L. pneumophila copes with this variation.
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    Research Areas: infectious disease, Legionella pneumophila, genomics, pathogenesis, molecular biology
  • The Sun Laboratory

    Lab Website
    Principal Investigator:
    Shuying Sun, Ph.D.
    Pathology

    The nervous system has extremely complex RNA processing regulation. Dysfunction of RNA metaboli...sm has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.

    The Sun Lab is interested in deciphering the RNA processing pathways altered by the ALS-causative mutants to uncover the mechanisms of toxicity and molecular basis of cell type-selective vulnerability. Another major focus of the group is to identify small molecule and genetic inhibitors of neuron toxic factors using various high-throughput screening platforms. Finally, we are also highly interested in developing novel CRISPR technique-based therapeutic strategies. We seek to translate the mechanistic findings at molecular level to therapeutic target development to advance treatment options against neurodegenerative diseases.
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    Research Areas: ALS, neurodegeneration, RNA
  • Wei Dong Gao Lab

    Lab Website

    Work in the Wei Dong Gao Lab primarily focuses on heart failure and defining molecular and cell...ular mechanisms of contractile dysfunction. We use molecular biology and proteomic techniques to investigate the changes that myofilament proteins undergo during heart failure and under drug therapy. We're working to determine the molecular nature of nitroxyl (HNO) modification of tropomyosin. view more

    Research Areas: heart disease, contractile dysfunction, heart failure, cardiovascular diseases, molecular biology
  • William B. Guggino Lab

    Lab Website
    Principal Investigator:
    William Guggino, Ph.D.
    Physiology

    Work in the William B. Guggino Lab focuses on the structure of the cystic fibrosis transmembran...e conductance regulator (CFTR) and water channels; the molecular structure of transport proteins in epithelial cell membranes; and gene therapies to treat cystic fibrosis (CF) patients. We are also working to identify CF’s specific defect in chloride channel regulation. One recent study showed that insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR. view more

    Research Areas: cell biology, cystic fibrosis, kidney diseases, gene therapy, ion channels
  • Zachara Lab

    Lab Website

    Elevation of O-GlcNAc levels modulates numerous pathways in a manner consistent with increased ...cell survival, including the expression of heat shock proteins. The Zachara Lab's goal is to understand the O-GlcNAc regulated stress response, how this can be manipulated to improve patient outcome and how this response is misregulated in disease. view more

    Research Areas: stress response, proteomics, O-GlcNAc, heat shock proteins
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