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School of Medicine
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Our research laboratory is staffed by a dedicated and experienced team of sleep scientists, fellows, technicians, engineers, and students. Currently, we are focused on the following areas:
-Novel treatments for sleep apnea using electrical and nerve stimulation and chemogenetic techniques
-Cardiovascular and metabolic effects of sleep apnea and hypoxia
-Leptin and its impact on breathing and cardiovascular physiology
-Sleep disordered breathing at high altitude
-Dietary impacts on asthma
The research in the Svetlana Lutsenko Laboratory is focused on the molecular mechanisms that regulate copper concentration in normal and diseased human cells. Copper is essential for human cell homeostasis. It is required for embryonic development and neuronal function, and the disruption of copper transport in human cells results in severe multisystem disorders, such as Menkes disease and Wilson's disease. To understand the molecular mechanisms of copper homeostasis in normal and diseased human cells, we utilize a multidisciplinary approach involving biochemical and biophysical studies of molecules involved in copper transport, cell biological studies of copper signaling, and analysis of copper-induced pathologies using Wilson's disease gene knock-out mice.
The SIP Lab studies the mechanisms of normal and disordered swallowing. The team conducts research in the areas of swallowing rehabilitation after stroke, effects of aging on swallowing and measurement of swallowing physiology.
Viachaslau Barodka Lab
Work in the Viachaslau Barodka Lab focuses on key topics within the field of anesthesiology research, including vascular stiffness, blood transfusions and cardiovascular physiology. Our most recent studies have explored impaired red blood cell deformability following blood transfusions, the effects of erythrocyte storage duration on blood transfusions, perioperative use of angiotensin-converting enzyme inhibitors and the pathophysiology of vascular stiffness.