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  • Ernesto Freire Laboratory

    The Ernesto Freire Lab studies the use of novel drugs to treat disease. Our research has resulted in the development of a thermodynamic platform for drug discovery and optimization. Our aim is to achieve high binding affinity and selectivity as well as appropriate pharmacokinetics with the platform. We are currently focusing on drug targets such as HIV/-1 protease inhibitors (HIV/AIDS), plasmepsin inhibitors (malaria), HCV protease inhibitors (hepatitis C), coronavirus 3CL-pro protease inhibitors (SARS and other viral infections), HIV-1 gp120 inhibitors (HIV/AIDS), chymase inhibitors (cardiovascular disease) and beta lactamase inhibitors (antibiotic resistance).

    Research Areas: pharmaceuticals, thermodynamics, AIDS, drug discovery, HIV, protease inhibitors, malaria

    Principal Investigator

    Ernesto Freire, Ph.D.

    Department

    Biophysics and Biophysical Chemistry

  • Jeremy Greene Lab

    Research in the Jeremy Greene Lab focuses on the history of disease and the ways that medical technologies affect our understanding of what it means to be sick, healthy, normal or abnormal. Particular areas of interest include 20th century clinical medicine, pharmaceuticals, medical technology, medical anthropology and global health.

    Research Areas: global health, clinical medicine, pharmaceuticals, medical technology, medical anthropology, history of medicine

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