Research Lab Results for persistence
Andrea Cox LabPrincipal Investigator:
Andrea Cox, M.D., Ph.D.
Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a... focus on HIV and the hepatitis C virus (HCV). In our studies, we examine the role of the immune response upon exposure to HCV by examining responses to HCV in a longitudinal, prospective group of high-risk individuals. This enables us to compare the innate, humoral and cellular immune responses to infection with clearance versus persistence. Through our findings, we seek to identify mechanisms of protective immunity against HCV infection and improve HCV vaccine design. view moreResearch Areas: virology, vaccines, viral immunology, HIV, hepatitis C, T cells
Justin Bailey LabLab WebsitePrincipal Investigator:
Justin Bailey, M.D., Ph.D.
Research in the Justin Bailey Lab explores immune responses against hepatitis C virus (HCV), pa...rticularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus. Recent studies have demonstrated that early and broad neutralizing antibody (nAb) responses against HCV are associated with HCV clearance, suggesting a key role for nAb in limiting HCV replication. The findings of this research will enhance understanding of how HIV infection may contribute to the lower rate of HCV clearance in HCV/HIV coinfected individuals, and the results could have implications for persistence of other viruses commonly occurring as coinfections with HIV. view moreResearch Areas: humoral immune response, vaccines, infectious disease, AIDS, HIV, hepatitis C
Karakousis LabLab WebsitePrincipal Investigator:
Petros Karakousis, M.D.
The Karakousis Lab is primarily focused on understanding the molecular basis of Mycobacterium t...uberculosis persistence and antibiotic tolerance. A systems biology-based approach, including the use of several novel in vitro and animal models, in combination with transcriptional, proteomic, genetic, imaging, and computational techniques, is being used to identify host cytokine networks responsible for immunological control of M. tuberculosis growth, as well as M. tuberculosis regulatory and metabolic pathways required for bacillary growth restriction and reactivation. In particular, we are actively investigating the regulatory cascade involved in the mycobacterial stringent response. Another major focus of the lab is the development of host-directed therapies for TB, with the goal of shortening treatment and improving long-term lung function. Additional research interests include the development of novel molecular assays for the rapid diagnosis of latent TB infection and active TB disease, and for the detection of drug resistance. view moreResearch Areas: diagnostics, persistence, infectious disease, Mycobacterium tuberculosis, host-directed therapy, latency, drugs, antibiotics, tuberculosis