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The Constance Monitto Lab conducts clinical research on pediatric pain management as well as basic science studies on chemotherapy resistance. In our pediatric pain management research, we work to assess the impact of low-dose opioid antagonism on opioid-related side effects, such as nausea and vomiting. We also analyze data on current methods of pediatric pain management in the United States. In addition, our team uses basic science studies to assess the success of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer.
Work in the Courtney Robertson Lab is focused on identifying interventions that could minimize the neurological deficits that can persist after pediatric traumatic brain injury (TBI). One study used a preclinical model to examine potential disruption of mitochondrial function and alterations in cerebral metabolism. It was found that a substantial amount of mitochondrial dysfunction is present in the first six hours after TBI. In addition, we are using nuclear magnetic resonance spectroscopy to evaluate global and regional alterations in brain metabolism after TBI. We're also collaborating with researchers at the University of Pennsylvania to compare mitochondrial function after head injury in different clinically relevant models.
Research in the Deborah Schwengel Lab focuses on perioperative care of pediatric patients with obstructive sleep apnea as well as anesthetic care for patients undergoing ethanol embolization of vascular malformations. Our team also explores topics within graduate medical education. In this field, our work has involved evaluating both an educational curriculum and a disaster preparedness curriculum for anesthesiology residents. We also have a long-standing interest in international adoption medicine.
Established in 1979, the Johns Hopkins DNA Diagnostic Laboratory is a CLIA and CAP certified; Maryland, New York, and Pennsylvania licensed clinical genetics testing laboratory specializing in rare inherited disorders. Led by renown professor of pediatrics and medical genetics Dr. Garry R. Cutting, the lab offers testing for a range of approximately 50 phenotypes and disorders totaling 3,500 tests annually.
Work in the Donald Shaffner Lab investigates several topics within critical care medicine. Our team conducts research on the mechanisms involved in neurologic injury from global ischemia as a result of cardiac arrest and resuscitation. We also study neurologic outcomes of pediatric patients who experience cardiac arrest.
Researchers in the Elizabeth Hunt Lab study innovative ways to improve the care quality and clinical outcomes of children who suffer cardiopulmonary arrest. Our work includes implementing rapid-response systems, capturing and analyzing cardiac-arrest data, and redesigning medical devices and simulators. We've introduced novel simulation approaches to education, including data-driven debriefing and the Rapid Cycle Deliberate Practice approach.
Research in the Eric McCollum Lab focuses on pediatric pulmonary medicine, particularly pulmonary diseases among children in undeveloped, low-resource countries. We are taking part in the IMPACT trial, which looks at the impact of bubble continuous positive airway pressure (bCPAP) on the mortality of Malawian children with pneumonia.
Dr. Jantzie, associate professor, received her Ph.D. in Neurochemistry from the University of Alberta in 2008. In 2013 she completed her postdoctoral fellowship in the Department of Neurology at Boston Children's Hospital & Harvard Medical School and became faculty at the University of New Mexico. Dr. Jantzie then joined the faculty Departments of Pediatrics (Neonatal-Perinatal Medicine) and Neurology at Johns Hopkins University and the Kennedy Krieger Institute in January 2019. Her lab investigates the pathophysiology of encephalopathy of prematurity, and pediatric brain injury common to infants and toddlers. Dr. Jantzie is dedicated to understanding disease processes in the developing brain as a means to identifying new therapeutic strategies and treatment targets for perinatal brain injury. Her lab studies neural substrates of cognition and executive function, inhibitory circuit formation, the role of an abnormal intrauterine environment on brain development, mechanisms of neurorepa...ir and microglial activation and polarization. Using a diverse array of clinically relevant techniques such as MRI, cognitive assessment, and biomarker discovery, combined with traditional molecular and cellular biology, the Jantzie lab is on the front lines of translational pediatric neuroscience.? view more
Research in the Jennifer Lee-Summers Lab explores cerebrovascular autoregulation, particularly during anesthesia. Our previous studies have examined cerebrovascular autoregulation and blood flow in patients with hypothermia, in neonatal patients with hypoxic-ischemic encephalopathy and in pediatric patients with moyamoya disease.
Principal Investigator
Department
The Joanne Shay Lab primarily conducts research on pediatric pain management techniques. Our studies have explored pain management in special-needs children and patients, and we have studied non-traditional pain management methods, such as regional anesthesia and peripheral nerve blocks in children, medical acupuncture, and remote anesthesia services. We also have an ongoing interest in the business of medicine.
The Jonathan Walsh Lab is currently researching longitudinal trends of diagnostic and procedural utilization in pediatric patients with head and neck complaints.
Research in the M-Irfan Suleman Lab focuses on better understanding and controlling pediatric pain. We've played a key role in the discovery of novel techniques for post-surgical pain management in children.
Research in the Nicholas Dalesio Lab is currently examining pre-surgical predictors of post-surgical respiratory complications in children with obstructive sleep apnea and sleep-disordered breathing; the impact of anesthesia and pharmacological agents on upper airway physiology; and techniques for pediatric airway imaging.
Research in the Patrick Breysse Lab seeks to better understand the biological, chemical and physical factors that can impact a patient’s health. Our team is currently studying the effects of indoor and outdoor air pollution on childhood asthma, respiratory tract infections, chronic obstructive pulmonary disease (COPD) and other respiratory conditions. We also conduct research on secondhand smoke exposure around the world and have participated in a range of health and exposure studies in Peru, Nepal, Mongolia, Columbia and India.
Research in the Rahul Koka Lab focuses on pediatric airways, patient safety and health disparities. Recent studies have focused on the relationship between socioeconomic status and perioperative outcomes and patient safety factors related to interoperative cardiac arrests. We also performed effects analyses of the maintenance and repair of anesthetic equipment in various medical environments.
Dr. Raul Chavez-Valdez is an assistant professor in the Department of Pediatrics with great interest in the mechanisms of delayed injury and repair/regeneration in the developing neonatal brain following injury, specifically following hypoxic-ischemic encephalopathy (birth asphyxia). He collaborates with Dr. Frances Northington (Pediatrics) and Dr. Lee Martin (Pathology/Neuroscience) in unveiling the importance of programmed necrosis in the setting of brain injury induced by birth asphyxia. He is especially interested in the role of brain derived neurotrophic factor and neurotrophin-4 following birth asphyxia and the changes that may explain the suspected excitatory/ inhibitory (E/I) imbalance particularly in the hippocampus. His work is highly translational since delayed hippocampal injury due to E/I imbalance may explain memory deficits observed despite therapeutic hypothermia in neonates suffering birth asphyxia. All of these aspects of developmental neuroplasticity are the base of ...his Career Development Award (NIH/NINDS-K08 award) and applications to other agencies. Additionally, he is part of multiple clinical efforts as part of the Neuroscience Intensive Care Nursery (NICN). He has been a Sutland-Pakula Endowed Fellow of Neonatal Research since September 2013. view more
Researchers in the Robert Greenberg Lab examine anesthesiology and critical care-related topics that include critical airway management, non-invasive fetal monitoring, neural blockade monitoring, pediatric acute pain management, cuffed oropharyngeal airway (COPA), pain informatics, and pediatric pain education and innovation.
Investigators in the Shivani Patel Lab study ways to improve intraoperative resuscitation during pediatric surgeries.
Principal Investigator
Department
The Boss Lab's research focus is on patient experience, health disparities, and surgical outcomes and utilization. Studies include shared decision-making, communication, and patient/parent-reported outcomes for elective surgery in children; patient satisfaction metrics, outcomes, and health correlates in surgery and pediatrics; patient and family-centered care and communication in surgery and pediatrics; racial, ethnic, and socioeconomic disparities in pediatric surgical care utilization and outcomes; and quality and safety in pediatric surgical care
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