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Research Lab Results for pediatric surgery

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  • Kunisaki Lab

    Principal Investigator:
    Shaun Kunisaki, M.D., M.Sc.
    Surgery

    The Kunisaki lab is a R01-funded regenerative medicine group within the Division of General Pediatric Surgery at Johns Hopkins that works at the interface of stem cells, mechanobiology, and materials science. We seek to understand how biomaterials and mechanical forces affect developing tissues relevant to pediatric surgical disorders. To accomplish these aims, we take a developmental biology approach using induced pluripotent stem cells and other progenitor cell populations to understand the cellular and molecular mechanisms by which fetal organs develop in disease.


    Our lab projects can be broadly divided into three major areas: 1) fetal spinal cord regeneration 2) fetal lung development 3) esophageal regeneration


    Lab members: Juan Biancotti, PhD (lab manager); Lynn Zhou, PhD (postdoc), Shelby Sferra, MD, MPH (postdoc); Annalise Penikis, MD (postdoc)


    Recent publications:
    Kunisaki SM, Jiang G, Biancotti JC, Ho KKY, Dye BR, Liu AP, Spence JR. Human indu...ced pluripotent stem cell-derived lung organoids in an ex vivo model of congenital diaphragmatic hernia fetal lung. Stem Cells Translational Medicine 2021, PMID: 32949227


    Biancotti JC, Walker KA, Jiang G, Di Bernardo J, Shea LD, Kunisaki SM. Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in an ex vivo model of prenatal spina bifida repair. Journal of Tissue Engineering 2020, PMID: 32782773.


    Kunisaki SM. Amniotic fluid stem cells for the treatment of surgical disorders in the fetus and neonate. Stem Cells Translational Medicine 2018, 7:767-773

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    Research Areas: fetal therapy, stem cells, pediatric surgery, tissue engineering, congenital diaphragmatic hernia, myelomeningocele
  • Laboratory for Fetal and Neonatal Organ Regeneration

    Principal Investigator:
    Shaun Kunisaki, M.D., M.Sc.
    Surgery

    Researchers in the Laboratory for Fetal and Neonatal Organ Regeneration in the Department of Surgery at the Johns Hopkins School of Medicine are studying whether cellular reprogramming, stem cells, and ex vivo modeling can be applied to improve organ regeneration in pediatric surgical patients.

    To execute these aims, the lab collaborates with developmental biologists and biomedical engineers throughout the country and employs cutting-edge molecular strategies and pre-clinical animal models.

    Research Areas: stem cells, pediatric surgery, congenital anomalies, tissue engineering
  • Shivani Patel Lab

    Investigators in the Shivani Patel Lab study ways to improve intraoperative resuscitation during pediatric surgeries.

    Research Areas: pediatric surgery, pediatrics, intraoperative resuscitation
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