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The Kunisaki lab is a regenerative medicine group within the Division of General Pediatric Surgery at Johns Hopkins that works at the interface of stem cells, mechanobiology, and material science. We seek to understand how biomaterials and mechanical forces affect developing tissues relevant to pediatric surgical disorders. To accomplish these aims, we take a developmental biology approach using induced pluripotent stem cells and other progenitor cell populations to understand the cellular and molecular mechanisms by which fetal organs develop in disease.
Our lab projects can be broadly divided into three major areas:
1) fetal spinal cord regeneration
2) fetal lung development
3) esophageal regeneration
Laboratory for Fetal and Neonatal Organ Regeneration
Researchers in the Laboratory for Fetal and Neonatal Organ Regeneration in the Department of Surgery at the Johns Hopkins School of Medicine are studying whether cellular reprogramming, stem cells, and ex vivo modeling can be applied to improve organ regeneration in pediatric surgical patients.
To execute these aims, the lab collaborates with developmental biologists and biomedical engineers throughout the country and employs cutting-edge molecular strategies and pre-clinical animal models.