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  • Mark Donowitz Lab

    Lab Website
    Principal Investigator:
    Mark Donowitz, M.D.
    Medicine

    Research in the Mark Donowitz Lab is primarily focused on the development of drug therapy for d...iarrheal disorders, intestinal salt absorption and the proteins involved including their regulation, and the use of human enteroids to understand intestinal physiology and pathophysiology. We study two gene families initially recognized by this laboratory: mammalian Na/H exchangers and the subgroup of PDZ domain containing proteins present in the brush border of epithelial cells called NHERF family. A major finding is that NHE3 exists simultaneously in different sized complexes in the brush border, which change separately as part of signal transduction initiated by mimics of the digestive process. Relevance to the human intestine is being pursued using mini-human intestine made from Lgr5+ stems cells made from intestinal biopsies and measuring function via two-photon microscopy. view more

    Research Areas: gastrointestinal system, gastroenterology, pathophysiology, diarrhea, drugs, physiology
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