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Research Lab Results for pathophysiology

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  • Adult Cardiac Catheterization Laboratory

    Our group is interested in the evaluation of basic pathophysiology in patients undergoing cardiac procedures, development and evaluation of new therapeutic strategies, and improving patient selection and outcomes following interventional procedures.

    Research Areas: cardiac catheterization, Acute Myocardial Infarction
  • Gilotra Lab

    The main focus of Dr. Gilotra's research is understanding the pathophysiology and outcomes in inflammatory cardiomyopathies including myocarditis and sarcoidosis, as well as improvement of heart failure patient care through noninvasive hemodynamic monitoring and studying novel strategies to reduce heart failure hospitalizations. Additional investigations involve clinical research in advanced heart failure therapies including heart transplantation and mechanical circulatory support. Dr. Gilotra is the site Principal Investigator for the NIH/NHLBI funded Heart Failure Network trials.

    Research Areas: heart failure, cardiology, cardiomyopathy
  • Gregg Semenza Lab

    The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned and characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.

    Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S.

    Research Areas: cancer, oxygen, lung disease, genomics, HIF-1, pathogenesis, myocardial ischemia
  • Integrated Research Center for Fetal Medicine

    Lab Website

    Currently supported research includes pathophysiology of fetal brain development with intrauterine insults, ultrasound and bio- markers of fetal well-being and biomarkers for fetal disease stratification and response to treatment (such as magnesium sulfate administration or head cooling as in cases of neuroinflammation).

    Research Areas: fetal brain development
  • Interventional Cardiology Research Group

    Our group is interested in a broad array of clinical and translational investigations spanning the evaluation of basic pathophysiology in patients undergoing cardiac procedures, development and evaluation of new therapeutic strategies, and improving patient selection and outcomes following interventional procedures. We are comprised of a core group of faculty and dedicated research nurses as well as fellows, residents, and students. Projects range from investigator-initiated single-center observational studies to industry-sponsored multicenter phase 3 randomized controlled trials. We have established a database of all patients who have undergone TAVR at Johns Hopkins, which is providing the basis for several retrospective analyses and will serve as the foundation for future studies of TAVR. We are also engaged in collaborative projects with other groups from the Department of Medicine and other Departments including Cardiac Surgery, Anesthesiology, Radiology, Psychiatry, and Biomedical... Engineering. Members of our group are actively involved with the Johns Hopkins Center for Bioengineering Innovation and Design (CBID) in the development of novel minimally-invasive cardiovascular devices. view more

    Research Areas: coronary CT angiography, PCI, bioprosthetic leaflet thrombosis, myocardial regeneration, TAVR
  • Ivor Berkowitz Lab

    Research in the Ivor Berkowitz Lab targets pediatric critical care medicine. We are particularly interested in the pathophysiology behind the cerebrovascular dysfunction that occurs in bacterial meningitis as well as the anesthetic and perioperative complications of patients with dwarfing syndromes.

    Research Areas: cerebrovascular dysfunction, bacterial meningitis, dwarfing syndromes, pediatric critical care medicine
  • Jantzie Lab

    Dr. Jantzie, associate professor, received her Ph.D. in Neurochemistry from the University of Alberta in 2008. In 2013 she completed her postdoctoral fellowship in the Department of Neurology at Boston Children's Hospital & Harvard Medical School and became faculty at the University of New Mexico. Dr. Jantzie then joined the faculty Departments of Pediatrics (Neonatal-Perinatal Medicine) and Neurology at Johns Hopkins University and the Kennedy Krieger Institute in January 2019. Her lab investigates the pathophysiology of encephalopathy of prematurity, and pediatric brain injury common to infants and toddlers. Dr. Jantzie is dedicated to understanding disease processes in the developing brain as a means to identifying new therapeutic strategies and treatment targets for perinatal brain injury. Her lab studies neural substrates of cognition and executive function, inhibitory circuit formation, the role of an abnormal intrauterine environment on brain development, mechanisms of neurorepa...ir and microglial activation and polarization. Using a diverse array of clinically relevant techniques such as MRI, cognitive assessment, and biomarker discovery, combined with traditional molecular and cellular biology, the Jantzie lab is on the front lines of translational pediatric neuroscience.? view more

    Research Areas: Neonatology, neuroscience
  • John Aucott Lab

    Research in the John Aucott Lab focuses on the development of accurate diagnostic tests for all stages of Lyme disease. We work closely with Dr. Mark Soloski on the Study of Lyme disease Immunology and Clinical Events (SLICE), a longitudinal, matched-control study of patients diagnosed with early untreated Lyme disease. The objective is to use the collected biological samples to help identify novel Lyme disease biomarkers that can inform diagnoses, outcomes and the knowledge about disease pathophysiology.

    Research Areas: clinical outcomes, gender differences, biomarkers, pathophysiology, immune heterogeneity, Lyme disease
  • Krishnan Lab

    Dr. Krishnan, Assistant Professor, received his Ph.D. in Biochemistry-Biotechnology from the University of Madras in 2008. He completed his postdoctoral fellowship in the Department of Pediatrics at the University of Alabama at Birmingham and Department of Pediatrics, University of Illinois at Chicago. After he worked as Research Associate in Department of Pediatrics at the University of South Florida, Dr. Krishnan joined the faculty at JHU in May 2018. His lab investigates the pathophysiology of Transfusion-associated Necrotizing Enterocolitis (TANEC) and Systemic Inflammatory Response Syndrome (SIRS) in premature infants who are at high risk of anemia and heavily transfused. Dr. Krishnan is dedicated to understanding the role of monocyte/macrophage in the neonate and investigating their inflammatory phenotype, function during anemia and/or RBC-transfusion associated NEC and SIRS.

    Research Areas: Systemic Inflammatory Response Syndrome (SIRS), Transfusion-associated Necrotizing Enterocolitis (TANEC), pediatrics
  • Mark Donowitz Lab

    Lab Website

    Research in the Mark Donowitz Lab is primarily focused on the development of drug therapy for diarrheal disorders, intestinal salt absorption and the proteins involved including their regulation, and the use of human enteroids to understand intestinal physiology and pathophysiology. We study two gene families initially recognized by this laboratory: mammalian Na/H exchangers and the subgroup of PDZ domain containing proteins present in the brush border of epithelial cells called NHERF family. A major finding is that NHE3 exists simultaneously in different sized complexes in the brush border, which change separately as part of signal transduction initiated by mimics of the digestive process. Relevance to the human intestine is being pursued using mini-human intestine made from Lgr5+ stems cells made from intestinal biopsies and measuring function via two-photon microscopy.

    Research Areas: gastrointestinal system, gastroenterology, pathophysiology, diarrhea, drugs, physiology
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