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Displaying 21 to 30 of 49 results for pathogenesis

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  • Laboratory of Airway Immunity

    We are interested in understanding how innate immune responses regulate lung health. Innate immunity involves ancient, and well-conserved mediators and their actions regulate the balance between homeostasis and pathogenesis. In the lungs, innate immunity play a critical role in response to environmental exposures such as allergen and ambient particulate matter. My lab focuses on how these exposures can promote aberrant mucosal responses that can drive the development of diseases like asthma.

    Research Areas: allergy, type 2 immunity, asthma, particulate matter, allergens, innate immunity

  • Maheshwari Lab

    We study the pathogenesis of neonatal necrotizing enterocolitis, which is a leading cause of morbidity and mortality in premature infants.

    Research Areas: blood transfusions, intestinal injury, neonate, inflammation, premature infants, macrophages

    Principal Investigator

    Akhil Maheshwari, M.B.B.S., M.D.

    Department

    Pediatrics

  • Michael B. Streiff Lab

    The Michael B. Streiff Lab conducts clinical and laboratory research of thrombophilia associated with malignancy. We are interested in the application of novel coagulation assays to explore the pathogenesis of thrombosis and the development of strategies to enhance the clinical management of anti-thrombotic agents.

    Research Areas: cancer, thrombophilia

    Principal Investigator

    Michael Streiff, M.D.

    Department

    Medicine

  • Michael Kornberg Lab

    Our laboratory conducts basic and translational research aimed at better understanding the pathogenesis of multiple sclerosis (MS) and the role of the immune system in CNS disease, particularly the processes that drive progressive disability such as neurodegeneration and remyelination failure. We currently have three parallel research programs: 1. Metabolism as a modulator of MS: We are studying how basic metabolic pathways regulate the immune system and how these pathways might be exploited to protect neurons and myelin-forming oligodendrocytes from injury. 2. Identifying pathways by which nitric oxide (NO) and other free radicals cause neuronal and axonal damage. Our lab is identifying specific signaling pathways initiated by NO and other free radicals that can be targeted by drugs to produce neuroprotection. 3. Modulating the innate immune system in MS: In collaboration with others at Johns Hopkins, we are studying ways to enhance the reparative functions of microglia while preventi...ng maladaptive responses. This work has identified bryostatin-1 as a potential drug that may be re-purposed for this task. view more

    Research Areas: multiple sclerosis

    Principal Investigator

    Michael Kornberg, M.D., M.S., Ph.D.

    Department

    Neurology

  • Mikhail Pletnikov Laboratory

    The Mikhail Pletnikov Laboratory is interested in the neurobiology of neurodevelopmental diseases such as schizophrenia and autism. The major focus of our laboratory is to evaluate how adverse environmental factors and vulnerable genes interact to affect brain and behavior development. We address these experimental questions by using methods of cell and molecular biology, neuroimmunology, neurochemistry, psychopharmacology and developmental psychobiology. The current projects in our laboratory are: (1) Genetic risk factors in neuron-astrocyte interaction during neurodevelopment, (2) Gene-environment interplay in the pathogenesis of psychiatric conditions, and (3) The neuroimmune interactions in abnormal neurodevelopment

    Research Areas: autism, immunology, neurobiology, cell biology, neurodevelopment, developmental psychobiology, schizophrenia, pharmacology, chemistry, molecular biology

  • Neuroimmunopathology Lab

    The research activities of the Neuroimmunopathology Laboratory focus on studies of immunological and molecular mechanisms involved in the pathogenesis of neurological disorders. Our main areas of research include studies of neurological complications of HIV infection and AIDS, multiple sclerosis, transverse myelitis, autism and epilepsy. We seek to explore and identify immunopathological mechanisms associated with neurological disease that may be the target of potential therapeutic interventions. The laboratory collaborates with other researchers and laboratories at Johns Hopkins and other institutions in projects related with studies of the interaction between the immune and central nervous systems in pathological processes leading to neurological dysfunction.

    Research Areas: multiple sclerosis, autism, epilepsy, HIV, transverse myelitis

    Principal Investigator

    Carlos Pardo-Villamizar, M.D.

    Department

    Neurology
    Neurosurgery

  • Neuromyelitis Optica Research Lab

    Neuromyelitis optica (NMO), also known as Devic's disease, is a neuroinflammatory disorder of the optic nerves and spinal cord. Our lab is focused on understanding the pathogenesis of NMO using animal models and cell culture techniques. Recent studies have found an antibody in NMO patients, the NMO-IgG disease, that binds aquaporin-4 (AQP4) found on astrocytes and other cell types.We are trying to understand the relationship of the NMO-IgG to the pathogenesis of NMO. We are also focused on understanding why NMO preferentially attacks the optic nerves and spinal cord. Toward this goal, we found that AQP4 isoforms are differentially expressed on astrocytes in these tissues compared to other tissues in the nervous system (see publications). Aquaporin-4 isoform expression may be critically important in predisposition to disease in NMO.

    Research Areas: neurofibromatosis

    Principal Investigator

    Michael Levy, M.D., Ph.D.

    Department

    Neurology

  • Nicola Heller Lab

    Research in the Nicola Heller Lab focuses on the immunobiology of macrophages. Our team explores how these cells impact diseases with an inflammatory element, such as cancer, cardiovascular disease and obesity. Using a variety of techniques, including molecular and cellular biology, biochemistry, mouse models and more, we study the role of IL-4/IL-13 signaling in asthma and allergic disease, as well as the role of alternatively activated macrophages (AAM) in the pathogenesis of allergic inflammation. Currently, we are researching the links between asthma and obesity, with a focus on the roles of gender and race.

    Research Areas: asthma, allergies, immunobiology, inflammation, macrophages

  • Philip Wong Lab

    The Philip Wong Lab seeks to understand the molecular mechanisms and identification of new therapeutic targets of neurodegenerative diseases, particularly Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Taking advantage of discoveries of genes linked to these diseases (mutant APP and PS in familial AD and mutant SOD1, dynactin p150glued ALS4and ALS2 in familial ALS), our laboratory is taking a molecular/cellular approach, including transgenic, gene targeting and RNAi strategies in mice, to develop models that facilitate our understanding of pathogenesis of disease and the identification and validation of novel targets for mechanism-based therapeutics. Significantly, these mouse models are instrumental for study of disease mechanisms, as well as for design and testing of therapeutic strategies for AD and ALS.

    Research Areas: neurodegenerative disorders, ALS, genomics, pathogenesis, Alzheimer's disease

    Lab Website

    Principal Investigator

    Philip Wong, Ph.D.

    Department

    Pathology

  • Post Lab

    The Post Lab is involved in the Multi-Ethnic Study of Atherosclerosis (MESA), a collaborative study of the characteristics of subclinical cardiovascular disease (that is, disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.

    As MESA researchers, we study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.

    Participants were recruited from six field centers across the United States, including Johns Hopkins University. Each participant received an extensive physical exam to determine a number of conditions, including coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, standard coron...ary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors.

    Selected repetition of subclinical disease measures and risk factors at follow-up visits have allowed study of the progression of disease. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality.

    Wendy S. Post, MD, MS, is an associate faculty, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, and a professor of medicine.
    view more

    Research Areas: coronary artery disease, cardiovascular, ethnicity, pathogenesis, atherosclerosis, sudden cardiac death

    Lab Website

    Principal Investigator

    Wendy Post, M.D., M.S.

    Department

    Medicine

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