Research Lab Results for pathobiology
Borahay Lab: Gynecologic and Fibroids ResearchLab WebsitePrincipal Investigator:
Mostafa Borahay, M.B.B.Ch., M.D., Ph.D., M.B.A., M.Sc.
Gynecology and Obstetrics
Dr. Borahay's lab focuses on understanding pathobiology, developing novel treatments, and carry...ing out high quality clinical trials for common gynecologic problems with a special focus on uterine fibroids. Our lab also investigates the causes and novel treatments for menstrual disorders such as heavy and irregular periods. In addition, Dr. Borahay’s team explores innovative approaches to minimally invasive gynecologic surgery, focusing on outpatient procedures with less pain and faster recovery times. view moreResearch Areas: uterine fibroids, outpatient surgery, endometriosis, stem cells, tumor biology, laparoscopic surgery, novel therapeutics, signaling pathways, Uterine biology, menstruation, robotic surgery, minimally invasive surgery, heavy periods, tissue engineering, menorrhagia, uterine model
GI Biomarkers LaboratoryPrincipal Investigator:
Stephen Meltzer, M.D.
The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biom...arkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches. view moreResearch Areas: gastrointestinal system, translational research in Barrett’s esophagus-associated neoplastic progression, Molecular pathophysiology, biomarkers, cancer, epigenetics, genomics, bioinformatics, biogenesis
GI Early Detection Biomarkers LabPrincipal Investigator:
Stephen Meltzer, M.D.
Dr. Meltzer is an internationally renowned leader in the molecular pathobiology of gastrointest...inal malignancy and premalignancy. He invented molecular methods to detect loss of heterozygosity in tiny biopsies, triggering an avalanche of research on precancerous lesions. He was the first to comprehensively study coding region microsatellite instability, leading to the identification of several important tumor suppressor genes. He performed several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the GI research paradigm toward genome-wide approaches. He directed an ambitious nationwide validation study of DNA methylation-based biomarkers for the prediction of neoplastic progression in Barrett’s esophagus.Research Areas: gastrointestinal cancer, gastrointestinal
Dr. Meltzer founded and led the Aerodigestive Cancer and Biomarker Interdisciplinary Programs at the University of Maryland, also becoming associate director for core sciences at that school’s Cancer Center. He currently holds an endowed professorship and is the director of GI biomarker research at Johns Hopkins.
The laboratory group focuses its efforts on the molecular genetics of gastrointestinal cancers and premalignant lesions, as well as on translational research to improve early detection, prognostic evaluation, and treatment of these conditions. Below, some examples of this work are described. view more
Robert Wise LabPrincipal Investigator:
Robert Wise, M.D.
The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD).... We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma. view moreResearch Areas: critical care medicine, emphysema, scleroderma, pulmonary medicine, asthma, lung-volume reduction surgery, COPD