The Caterina lab is focused on dissecting mechanisms underlying acute and chronic pain sensatio...n. We use a wide range of approaches, including mouse genetics, imaging, electrophysiology, behavior, cell culture, biochemistry and neuroanatomy to tease apart the molecular and cellular contributors to pathological pain sensation. A few of the current projects in the lab focus on defining the roles of specific subpopulations of neuronal and non-neuronal cells to pain sensation, defining the role of RNA binding proteins in the development and maintenance of neuropathic pain, and understanding how rare skin diseases known as palmoplantar keratodermas lead to severe pain in the hands and feet. view more

Work in the Michael Erdek Lab explores interventional pain management and cancer pain managemen...t. Our studies focus on the assessment and interventional treatment of cancer-related pain and intrathecal therapy for spasticity resistant to management by oral medications. We also conduct research on the use of spinal cord stimulation as a treatment for neuropathic pain, refractory angina pectoris and refractory peripheral vascular disease. view more

Research in the M-Irfan Suleman Lab focuses on better understanding and controlling pediatric p...ain. We've played a key role in the discovery of novel techniques for post-surgical pain management in children. view more

Researchers in the Pankaj Jay Pasricha Lab are interested in the molecular mechanisms of viscer...al pain and restoration of enteric neural function with novel strategies, including neural stem cell transplants. Recent research has focused on the enteric nervous system and gut-brain axis, and the complexity of pain in chronic pancreatitis. Another recent study indicates that patients with underlying small intestinal bacterial overgrowth have significant delays in small bowel transit time as compared to those without, while another explored the safety and efficacy of carbon dioxide cryotherapy for treatment of neoplastic Barrett's esophagus. view more

Work in the Paul Jordan Christo Lab is focused on pain management in older adults, thoracic out...let syndrome therapies, spinal chord stimulation and the usage of online education modules for pain education. Recent research has investigated novel therapies for thoracic outlet syndrome (including the use of botulinum toxin), the sexual side effects of chronic opioid therapy and complex regional pain syndrome. view more

The team headed by Shenandoah “Dody” Robinson, M.D., professor of neurosurgery, neurology and p...ediatrics, studies perinatal brain injury and repair. Employing developmentally age-appropriate models, the lab investigates neurological consequences of extremely preterm birth, including cerebral palsy, chronic pain, cognitive and behavioral impairment, epilepsy and posthemorrhagic hydrocephalus of prematurity. view more

Researchers in the Robert Greenberg Lab examine anesthesiology and critical care-related topics... that include critical airway management, non-invasive fetal monitoring, neural blockade monitoring, pediatric acute pain management, cuffed oropharyngeal airway (COPA), pain informatics, and pediatric pain education and innovation. view more

Investigators in the Roger Johns Lab are examining the molecular mechanisms behind the onset an...d continuation of chronic pain, particularly neuropathic pain. This work has led to a better understanding of the vast network of molecules at neuronal synapses, particularly the postsynaptic density (PSD), which is key to the propagation of pain signals. We're working to develop new analgesics that interfere with the PSD protein interactions in an effort to better treat patients who suffer from chronic pain. view more

The Ronen Shechter Lab is currently investigating a novel treatment for nerve pain induced by c...hemotherapy. Our previous research has involved studying the role and mechanism of peripheral opioids as well as the use of dorsal column stimulation to treat pain resulting from a condition affecting the nervous system. view more

Work in the Sivanesan Neuromodulation Laboratory (SNL) focuses on developing electrical stimula...tion therapies for treating neuropathic pain conditions and discovering novel applications for patients suffering from painful conditions. We study mechanisms of all modalities of spinal cord stimulation in the laboratory and aim to rapidly translate these discoveries to patient care. This bench to bedside approach facilitates a unique integration of the latest science with the clinical care of patients. view more