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  • Adult Cardiac Catheterization Laboratory

    Principal Investigator:
    Jon Resar, M.D.
    Medicine

    Our group is interested in the evaluation of basic pathophysiology in patients undergoing cardi...ac procedures, development and evaluation of new therapeutic strategies, and improving patient selection and outcomes following interventional procedures. view more

    Research Areas: cardiac catheterization, Acute Myocardial Infarction
  • Alicia Arbaje Lab

    Research in the Alicia Arbaje Lab aims to help older adults maintain dignity and quality of lif...e as they age. We are particularly interested in creating health care systems to improve safety and outcomes for older adults. view more

    Research Areas: safety, gerontology, health care systems
  • Alison E. Turnbull Lab

    Lab Website

    Research in the Alison E. Turnbull Lab focuses on patient-clinician interactions. We study deci...sion-making processes for ICU patients and their families and focus on the long-term outcomes of ICU survivors. Additional research examines ways to improve end-of-life care for patients. view more

    Research Areas: epidemiology, palliative care, medical decision making, ICU
  • Allan Gelber Lab

    The Allan Gelber Lab conducts research on the clinical epidemiology of rheumatic disorders. Our... recent studies have explored topics that include the predicting factors of prevalent and incident gout; cardiovascular disease burden and risk in patients with rheumatoid arthritis; autoantibodies in both primary and secondary SjogrenÕs syndrome; and predictors of outcomes in patients with scleroderma. In addition, we have a long-standing interest in the ways in which racial differences affect disease manifestations in relation to rheumatic disorders. view more

    Research Areas: rheumatology, gout, Sjogren's syndrome, scleroderma, race, health disparities, rheumatoid arthritis
  • Ana-Marie Orbai Lab

    Lab Website
    Principal Investigator:
    Ana-Maria Orbai, M.D., M.H.S.
    Medicine

    The Ana-Marie Orbai Lab focuses on inflammatory arthritis. Current clinical research projects i...n the lab examine patient symptoms and experiences in rheumatic diseases and inflammatory arthritis. We focus on stiffness in rheumatoid arthritis and patient-reported outcomes. Previous research in the lab focused on systemic lupus erythemaous (SLE). view more

    Research Areas: autoimmune rheumatic diseases, arthritis, rheumatoid arthritis
  • Ari Cedars Laboratory

    Principal Investigator:
    Ari Cedars, M.D.
    Medicine

    Ari Cedars, M.D., and his team have three primary research goals. First, the Cedars Lab is inte...rested in patient-centered outcomes in congenital heart disease, which they investigate using a digital tracking system to record participants’ symptoms and quality of life. Second, the Cedars Lab investigates outcomes with mechanical circulatory support and transplant in congenital heart disease, with a focus on those with end-stage heart disease and a Fontan circulation. Third, the Cedars Lab is interested in the biological mechanisms underlying circulatory deterioration and end-organ dysfunction in patients with a Fontan circulation. view more

    Research Areas: heart disease, congenital heart disease
  • Biophotonics Imaging Technologies (BIT) Laboratory

    Lab Website
    Principal Investigator:
    Xingde Li, Ph.D.
    Biomedical Engineering

    Research in the Biophotonics Imaging Technologies (BIT) Laboratory focuses on developing optica...l imaging and nano-biophotonics technology to reduce the random sampling errors in clinical diagnosis, improve early disease detection and guidance of biopsy and interventions, and improve targeted therapy and monitoring treatment outcomes. The imaging technologies feature nondestructiveness, unique functional and molecular specificity, and multi-scale resolution (from organ, to architectural morphology, cellular, subcellular and molecular level). The nano-biophotonics technologies emphasize heavily on biocompatibility, multi-function integration and fast track clinical translation. These imaging and nano-biophotonics technologies can also be potentially powerful tools for basic research such as for drug screening, nondestructive assessment of engineered biomaterials in vitro and in vivo, and for studying brain functions on awake animals under normal or controlled social conditions. view more

    Research Areas: drug screening, imaging, brain, nano-biophotonics
  • Bradford Winters Lab

    The Bradford Winters Lab conducts research on patient safety and quality of care. Our team focu...ses on the topics of patient care in the intensive care unit, evidence-based medicine, quality health care, and the measurement and evaluation of safety efforts. Currently our work involves evaluating pain management techniques in post-craniotomy patients, developing guidelines for policy development of patient safety initiatives and creating measures for rapid-response system outcomes. view more

    Research Areas: patient safety, ICU, evidence-based medicine, quality of care
  • Brain Tumor Laboratory

    Lab Website
    Principal Investigator:
    Henry Brem, M.D.
    Neurology
    Neurosurgery

    At the brain tumor laboratory, Henry Brem, M.D. and Betty Tyler, along with more than 350 train...ees, have conducted scientific research, contributed to scientific literature, amended clinical practice, and illuminated new pathways for improving clinical outcomes.



    The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. Dr. Brem and his colleagues have designed and led many multi-institutional clinical trials to improve and expand the range of therapeutic options for patients with brain tumors.
    view more

    Research Areas: brain tumor drug delivery, brain tumor
  • Cardiac Surgery Research Lab

    Lab Website
    Principal Investigator:
    Jennifer Lawton, M.D.
    Medicine
    Surgery

    Founded in 1942 by surgeon Alfred Blalock and surgical technician Vivien Thomas, the Cardiac Su...rgery Research Lab at The Johns Hopkins Hospital serves not only to spearhead discovery and innovation in cardiothoracic surgery, but also to train future leaders in the field. Active areas of investigation include the development of novel, nanoparticle-based therapeutics to mitigate acute lung injury, avoid neurological injury during cardiac surgery, and improve organ preservation during heart and lung transplantation. The lab is also active in a variety of clinical research projects aimed at improving outcomes for our patients.

    Equally important, the lab plays a critical role in training residents for impactful careers in academic cardiothoracic surgery. Medical students, residents, and fellows receive hands-on simulation experiences to hone surgical skills outside of the operating room. The lab also serves as a training ground to develop research and investigation skills as trainees learn methods of advanced statistical analysis and academic writing. Special programs for undergraduates and medical students help develop their passion for cardiac surgery and surgical research, giving unique opportunities to young talent.
    view more

    Research Areas: cardiac surgery, nanotechnology, cardiothoracic surgery, surgical models, heart transplant, lung transplant
  • Chirag Parikh Lab

    Lab Website
    Principal Investigator:
    Chirag Parikh, M.B.B.S., Ph.D.
    Medicine

    Dr. Parikh's research focuses on the translation and validation of novel biomarkers for the dia...gnosis and prognosis of acute kidney injury. Progress in kidney diseases has been hamstrung by significant heterogeneity within the current disease definitions, which are largely based on serum creatinine. Dr. Parikh's research has addressed this critical challenge by developing biomarkers of renal tubular injury, repair, and inflammation to dissect this heterogeneity. He has assembled multicenter longitudinal prospective cohorts for translational research studies across several clinical settings of acute kidney injury and chronic kidney disease for the efficient translation of novel biomarkers.



    His research is dedicated to the process of applying discoveries generated in the laboratory and in preclinical experiments, the development of clinical studies, and the design of clinical trials. Dr. Parikh's studies have refined the clinical definition in perioperative acute kidney injury and hepatorenal syndrome, developed strategies to reduce kidney discard in deceased donor transplantation, and advanced regulatory approvals of kidney injury biomarkers. He has also developed biomarkers to identify rapid progressors of early diabetic kidney disease before derangements in serum creatinine. Dr. Parikh's research goal is to translate our understanding of pathophysiological mechanisms into clinical practice and improve the outcomes in patients with kidney disease.



    Dr. Parikh has also been the recipient of numerous honors, including the 2017 Young Investigator Award from the American Society of Nephrology.
    view more

    Research Areas: acute kidney injury, biomarkers, Kidney Transplantation, chronic kidney disease
  • Christian Merlo Lab

    Principal Investigator:
    Christian Merlo, M.D., M.P.H.
    Medicine

    Work in the Christian Merlo Lab includes studies on pulmonary arteriovenous malformations, outc...omes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. Our recent research has also explored recipient and donor variables in the success or failure of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients. view more

    Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant
  • Christine Durand Lab

    Principal Investigator:
    Christine Durand, M.D.
    Medicine

    Dr. Christine Durand, assistant professor of medicine and oncology and member of the Johns Hopk...ins Kimmel Cancer Center, is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and HIV cure strategies including bone marrow transplantation.

    Dr. Durand is supported by multiple grants:

    • R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US.
    • K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection.
    • U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation.
    U01 from the NIAID to study HIV-to-HIV deceased donor liver transplantation.
    view more

    Research Areas: Bone Marrow Transplantation, transplants, infectious disease, AIDS, HIV, Solid Organ Transplantation, hepatitis C
  • David Thompson Lab

    Researchers in the David Thompson Lab examine the outcomes of patients treated in intensive car...e units (ICUs), patient safety efforts, quality improvement efforts, and multidisciplinary teamwork and safety curriculum development. We're taking part in a study aimed at reducing hospital-acquired infections among cardiovascular surgery patients. Our investigators also participated in a clinical research collaboration that saw an 81 percent reduction in bloodstream infections related to central lines. view more

    Research Areas: medical education, patient safety, quality improvement, infections, patient outcomes, ICU
  • Deidra Crews Lab

    Principal Investigator:
    Deidra Crews, M.D.
    Medicine

    Dr. Crews’ team focuses on health disparities in chronic kidney disease. We have studied how so...cial determinants of health, such as poverty and healthful food access, affect disparities in kidney disease outcomes. Our research on end-stage renal disease includes studies of the best timing and environment to initiate dialysis among vulnerable populations. view more

    Research Areas: poverty, chronic kidney disease, health disparities
  • Donald Shaffner Lab

    Work in the Donald Shaffner Lab investigates several topics within critical care medicine. Our ...team conducts research on the mechanisms involved in neurologic injury from global ischemia as a result of cardiac arrest and resuscitation. We also study neurologic outcomes of pediatric patients who experience cardiac arrest. view more

    Research Areas: hyperthermia, critical care medicine, cardiac arrest, resuscitation, ischemia, pediatrics, neurology
  • Elizabeth Daugherty Lab

    The Elizabeth Daugherty Lab conducts research on patient safety, critical care infection contro...l and critical care disaster response. We investigate methods of improving patient safety through improved infection control, with a focus on clinical outcomes, nosocomial infection rates and the individual and organizational obstacles to personal protective equipment adherence. view more

    Research Areas: critical care medicine, patient safety, infection control, nosocomial infections
  • Elizabeth Hunt Lab

    Researchers in the Elizabeth Hunt Lab study innovative ways to improve the care quality and cli...nical outcomes of children who suffer cardiopulmonary arrest. Our work includes implementing rapid-response systems, capturing and analyzing cardiac-arrest data, and redesigning medical devices and simulators. We've introduced novel simulation approaches to education, including data-driven debriefing and the Rapid Cycle Deliberate Practice approach. view more

    Research Areas: outcomes, pediatric cardiopulmonary arrest, rapid response systems, rapid cycle deliberate practice, pediatrics, quality of care
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