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  • Jean Kim Lab

    The Jean Kim Laboratory performs translational research in the
    area of chronic rhinosinusitis,... with a niche interest in the pathogenesis of hyperplastic nasal
    polyposis. Studies encompass clinical research to basic wet laboratory research in
    studying the underlying immune and autoimmune mediated mechanism of polyp growth and
    perpetuation of disease. Human cell and tissue culture models are used. Techniques in the
    laboratory include cell and tissue culture, real time PCR, immunoblot, ELISA, flow cytometry,
    immunohistochemistry, electron microscopy, gene array analysis, and other molecular
    approaches including genetic knockdowns. Approaches used in Dr. Kim’s clinical study
    designs include prospective and retrospective analysis of patient outcomes and clinical
    biomarkers, as wells controlled clinical trials.
    view more

    Research Areas: nasal polyps, chronic rhinosinusitis, hyperplastic nasal polyposis
  • Jinyuan Zhou Lab

    Lab Website

    Dr. Zhou's research focuses on developing new in vivo MRI and MRS methodologies to study brain ...function and disease. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, high-resolution diffusion tensor imaging (DTI), magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, and tissue protein MR imaging. Notably, Dr. Zhou and his colleagues invented the amide proton transfer (APT) approach for brain pH imaging and tumor protein imaging. His initial paper on brain pH imaging was published in Nature Medicine in 2003 and his most recent paper on tumor treatment effects was published in Nature Medicine in 2011. A major part of his current research is the pre-clinical and clinical imaging of brain tumors, strokes, and other neurologic disorders using the APT and other novel MRI techniques. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and improve the diagnostic capability of MRI and the patient outcomes. view more

    Research Areas: magnetic resonance, functional magnetic resonance imaging, brain, stroke
  • John Aucott Lab

    Principal Investigator:
    John Aucott, M.D.
    Medicine

    Research in the John Aucott Lab focuses on the development of accurate diagnostic tests for all... stages of Lyme disease. We work closely with Dr. Mark Soloski on the Study of Lyme disease Immunology and Clinical Events (SLICE), a longitudinal, matched-control study of patients diagnosed with early untreated Lyme disease. The objective is to use the collected biological samples to help identify novel Lyme disease biomarkers that can inform diagnoses, outcomes and the knowledge about disease pathophysiology. view more

    Research Areas: clinical outcomes, gender differences, biomarkers, pathophysiology, immune heterogeneity, Lyme disease
  • John Matthew Austin Lab

    Research in the John Matthew Austin Lab explores health care performance measures, with a goal ...of improving patient care by enabling healthcare providers to view data about their performance, track patient outcomes and comply with best care practices. Our lab is currently working to develop performance measures for the ICU part, and we are part of The Leapfrog Group, an annual survey of U.S. hospitals that compares hospital performance on national measures of safety, quality and efficiency. Our research also explores the use of scientifically sound decision-support tools for guiding improvements in healthcare delivery systems. view more

    Research Areas: health care quality, patient safety, health care performance, patient outcomes, ICU, information technology
  • Johns Hopkins Center for Fetal Therapy Research

    Lab Website

    Johns Hopkins experts have been at the forefront of research into the benefits and proven outco...mes of the most advanced prenatal surgery techniques to treat a range of conditions including congenital diaphragmatic hernia (CDH), spina bifida and twin-to-twin transfusion syndrome (TTTS). view more

    Research Areas: congenital diaphragmatic hernia (CDH), spina bifida, prenatal surgery, twin-to-twin transfusion syndrome (TTTS)
  • Jonathan Orens Lab

    Principal Investigator:
    Jonathan Orens, M.D.
    Medicine

    Research in the Jonathan Orens Lab examines topics such as clinical outcomes of lung transplant...ation, chronic allograft rejection and ischemic reperfusion injury, also known as primary graft dysfunction. view more

    Research Areas: ischemia-reperfusion injury, chronic allograft rejection, pulmonary medicine, lung transplant
  • Karen Bandeen-Roche Lab

    Principal Investigator:
    Karen Bandeen-Roche, Ph.D.
    Medicine

    The Karen Bandeen-Roche Lab explores the application of underlying variable methods in epidemio...logic and psychosocial research. Our team seeks to improve the ability to measure key outcomes like functional status and psychological disorders. Our other areas of statistical research include the study of classification and variance structure and multivariate survival analysis. We are deeply invested in the field of gerontology as well as ophthalmology and neurology. view more

    Research Areas: psychology, epidemiology, ophthalmology, data analysis, aging, biostatistics, gerontology, neurology
  • Kristin Riekert Lab

    Principal Investigator:
    Kristin Riekert, Ph.D.
    Medicine

    Work in the Kristin Riekert Lab focuses on methods for improving health care quality and delive...ry, particularly among underserved and disadvantaged populations. Our research covers a range of important topics, including health beliefs, treatment adherence, doctor-patient communication, self-management interventions, mobile health initiatives, health disparities and patient-reported outcome methodology. We also work with the National Institutes of Health on multiple intervention trials focused on improving adherence and health outcomes in asthma, chronic kidney disease, cystic fibrosis (CF), sickle cell disease and secondhand smoke reduction. view more

    Research Areas: health care quality, treatment adherence, cystic fibrosis, patient-provider relationships, chronic illnesses, health disparities
  • Laboratory of Computational Intensive Care Medicine (Stevens Lab)

    Lab Website

    The Johns Hopkins Laboratory of Computational Intensive Care Medicine (LCICM) has been establis...hed to gain knowledge on the mechanisms of critical illness and injury, with the aim of identifying novel methods to treat patients admitted to the intensive care unit (ICU). Members of the lab apply mathematical and statistical models, artificial intelligence, and domain expertise to unravel patterns in data from sources such as electronic health records, high-frequency physiological recordings, and medical imaging. These patterns are resolved into health signatures that can be leveraged for classification and prediction. The overarching goal is to enhance the precision, efficacy, and outcomes of care delivered to critically ill patients. view more

    Research Areas: Data Science, Intensive Care Medicine, Personalized Medicine
  • Laboratory of Vestibular NeuroAdaptation

    The Laboratory of Vestibular NeuroAdaptation investigates mechanisms of gaze stability in peopl...e with loss of vestibular sensation. A bulk of our research investigates motor learning in the vestibulo-ocular reflex (VOR) using different types of error signals. In addition, we investigate the synergistic relationship between the vestibular and saccadic oculomotor systems as trainable strategies for gaze stability. We are particularly interested in developing novel technologies to assess and deliver improved rehabilitation outcomes. We are validating a hand-held computer tablet for assessment of sensorimotor function and participating in a clinical trial comparing traditional vestibular rehabilitation against a device developed in our laboratory that can unilaterally or bilaterally strengthen the VOR.

    Members of the lab include physical therapists, physicians, engineers, statisticians and post-doctoral fellows. The laboratory is supported by generous grant funding from NASA, the NIH, the DOD and grateful patients
    view more

    Research Areas: gaze stability, vestibular sensation, vestibulo-ocular reflex, rehabilitation, sensorimotor functions
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