I Want To...
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
School of Medicine
I Want to...
Find a Research Lab
Jean Kim Lab
The Jean Kim Laboratory performs translational research in the
area of chronic rhinosinusitis, with a niche interest in the pathogenesis of hyperplastic nasal
polyposis. Studies encompass clinical research to basic wet laboratory research in
studying the underlying immune and autoimmune mediated mechanism of polyp growth and
perpetuation of disease. Human cell and tissue culture models are used. Techniques in the
laboratory include cell and tissue culture, real time PCR, immunoblot, ELISA, flow cytometry,
immunohistochemistry, electron microscopy, gene array analysis, and other molecular
approaches including genetic knockdowns. Approaches used in Dr. Kim’s clinical study
designs include prospective and retrospective analysis of patient outcomes and clinical
biomarkers, as wells controlled clinical trials.
Dr. Zhou's research focuses on developing new in vivo MRI and MRS methodologies to study brain function and disease. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, high-resolution diffusion tensor imaging (DTI), magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, and tissue protein MR imaging. Notably, Dr. Zhou and his colleagues invented the amide proton transfer (APT) approach for brain pH imaging and tumor protein imaging. His initial paper on brain pH imaging was published in Nature Medicine in 2003 and his most recent paper on tumor treatment effects was published in Nature Medicine in 2011. A major part of his current research is the pre-clinical and clinical imaging of brain tumors, strokes, and other neurologic disorders using the APT and other novel MRI techniques. The overall goal is to achieve the MRI contrast at the protein and peptide ...level without injection of exogenous agents and improve the diagnostic capability of MRI and the patient outcomes. view less
John Aucott Lab
Research in the John Aucott Lab focuses on the development of accurate diagnostic tests for all stages of Lyme disease. We work closely with Dr. Mark Soloski on the Study of Lyme disease Immunology and Clinical Events (SLICE), a longitudinal, matched-control study of patients diagnosed with early untreated Lyme disease. The objective is to use the collected biological samples to help identify novel Lyme disease biomarkers that can inform diagnoses, outcomes and the knowledge about disease pathophysiology.
John Matthew Austin Lab
Research in the John Matthew Austin Lab explores health care performance measures, with a goal of improving patient care by enabling healthcare providers to view data about their performance, track patient outcomes and comply with best care practices. Our lab is currently working to develop performance measures for the ICU part, and we are part of The Leapfrog Group, an annual survey of U.S. hospitals that compares hospital performance on national measures of safety, quality and efficiency. Our research also explores the use of scientifically sound decision-support tools for guiding improvements in healthcare delivery systems.
Research in the John McCloskey Lab focuses on quality improvements in the operating room and pediatric intensive care unit (PICU). Our work aims to improve the throughput of adolescents undergoing spinal fusions in order to better define interventions to ameliorate anesthesia emergence delirium and to improve protocols for sedation. One of our projects established an early oral feeding program for critically ill patients. Our goal is to enhance the delivery and quality of children’s health care while making it safer and more affordable.
Jon Russell Lab
The Jon Russell lab focuses on thyroid and parathyroid pathology as well as improving patient safety and education using healthcare technology. Additional focuses include utilizing new technology to advance on the techniques of minimally invasive neck surgery. Current and previous efforts include the development of mobile and web-based applications to educate physicians and patients, utilizing ultrasound for vocal cord imaging, understanding the nuances of advanced thyroid cancer, and exploring the role of scarless thyroid surgery in a North American population.
Karen Bandeen-Roche Lab
The Karen Bandeen-Roche Lab explores the application of underlying variable methods in epidemiologic and psychosocial research. Our team seeks to improve the ability to measure key outcomes like functional status and psychological disorders. Our other areas of statistical research include the study of classification and variance structure and multivariate survival analysis. We are deeply invested in the field of gerontology as well as ophthalmology and neurology.
Kelly Metcalf Pate Lab
The Kelly Metcalf Pate Lab focuses on the role of platelets in the innate immune response to viral infection, and how modulating the response of platelets to infection alters the course of disease.
Platelets are known to participate in innate immunity through cytokine signaling and direct interactions with other cells, and the platelet has the potential to significantly influence disease outcomes. However, platelet immunology is still a relatively new discipline, and the downstream effects of platelet interactions with other immune cells have yet to be determined in the context of viral infection.
Current research in our lab aims to further characterize the platelet-monocyte interaction during acute viral infection with the goals of establishing methods of pharmacologically manipulating this association, and establishing how platelet binding to a monocyte influences the monocyte's susceptibility to lentiviral infection and the monocyte's interactions with endothelium.
Additio...nally, we are interested in the effect of physiologic stress on the platelet's future immune response to infection, and in the development and optimization of novel in vitro systems that better model in vivo conditions.
Molecular and Comparative Pathobiology
Kristin Riekert Lab
Work in the Kristin Riekert Lab focuses on methods for improving health care quality and delivery, particularly among underserved and disadvantaged populations. Our research covers a range of important topics, including health beliefs, treatment adherence, doctor-patient communication, self-management interventions, mobile health initiatives, health disparities and patient-reported outcome methodology. We also work with the National Institutes of Health on multiple intervention trials focused on improving adherence and health outcomes in asthma, chronic kidney disease, cystic fibrosis (CF), sickle cell disease and secondhand smoke reduction.