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  • Hanan Aboumatar Lab

    Research in the Hanan Aboumatar Lab focuses on advancing patient-centered outcomes through improved patient and family involvement. We also focus on multilevel methods to increase the patient-centered focus of care delivery. Recent research examined the impact of a quality-improvement intervention on patient involvement in primary care and treatment with respect and dignity in intensive care.

    Research Areas: patient-centered health care, quality improvement, safety, patient outcomes

    Lab Website

    Principal Investigator

    Hanan Aboumatar, M.D., M.P.H.

    Department

    Medicine

  • Improving Outcomes Following Injury and Illness

    Led by Stephen Wegener, Ph.D, this research group focuses on projects that have the potential to improve function and quality of life and reduce disability following injury or illness. These projects include research on cognitive, behavioral, psychological and health care system factors that affect outcomes following injury.

    Research Areas: neuropsychology, amputation, patient-provider collaboration, disability, rehabilitation psychology, pain

  • Interventional Cardiology Research Group

    Our group is interested in a broad array of clinical and translational investigations spanning the evaluation of basic pathophysiology in patients undergoing cardiac procedures, development and evaluation of new therapeutic strategies, and improving patient selection and outcomes following interventional procedures. We are comprised of a core group of faculty and dedicated research nurses as well as fellows, residents, and students. Projects range from investigator-initiated single-center observational studies to industry-sponsored multicenter phase 3 randomized controlled trials. We have established a database of all patients who have undergone TAVR at Johns Hopkins, which is providing the basis for several retrospective analyses and will serve as the foundation for future studies of TAVR. We are also engaged in collaborative projects with other groups from the Department of Medicine and other Departments including Cardiac Surgery, Anesthesiology, Radiology, Psychiatry, and Biomedical... Engineering. Members of our group are actively involved with the Johns Hopkins Center for Bioengineering Innovation and Design (CBID) in the development of novel minimally-invasive cardiovascular devices. view more

    Research Areas: coronary CT angiography, PCI, bioprosthetic leaflet thrombosis, myocardial regeneration, TAVR

    Principal Investigator

    Jon Resar, M.D.

    Department

    Medicine

  • Jean Kim Lab

    The Jean Kim Laboratory performs translational research in the
    area of chronic rhinosinusitis, with a niche interest in the pathogenesis of hyperplastic nasal
    polyposis. Studies encompass clinical research to basic wet laboratory research in
    studying the underlying immune and autoimmune mediated mechanism of polyp growth and
    perpetuation of disease. Human cell and tissue culture models are used. Techniques in the
    laboratory include cell and tissue culture, real time PCR, immunoblot, ELISA, flow cytometry,
    immunohistochemistry, electron microscopy, gene array analysis, and other molecular
    approaches including genetic knockdowns. Approaches used in Dr. Kim’s clinical study
    designs include prospective and retrospective analysis of patient outcomes and clinical
    biomarkers, as wells controlled clinical trials.

    Research Areas: nasal polyps, chronic rhinosinusitis, hyperplastic nasal polyposis

  • Jinyuan Zhou Lab

    Dr. Zhou's research focuses on developing new in vivo MRI and MRS methodologies to study brain function and disease. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, high-resolution diffusion tensor imaging (DTI), magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, and tissue protein MR imaging. Notably, Dr. Zhou and his colleagues invented the amide proton transfer (APT) approach for brain pH imaging and tumor protein imaging. His initial paper on brain pH imaging was published in Nature Medicine in 2003 and his most recent paper on tumor treatment effects was published in Nature Medicine in 2011. A major part of his current research is the pre-clinical and clinical imaging of brain tumors, strokes, and other neurologic disorders using the APT and other novel MRI techniques. The overall goal is to achieve the MRI contrast at the protein and peptide ...level without injection of exogenous agents and improve the diagnostic capability of MRI and the patient outcomes. view less

    Research Areas: magnetic resonance, functional magnetic resonance imaging, brain, stroke

  • John Aucott Lab

    Research in the John Aucott Lab focuses on the development of accurate diagnostic tests for all stages of Lyme disease. We work closely with Dr. Mark Soloski on the Study of Lyme disease Immunology and Clinical Events (SLICE), a longitudinal, matched-control study of patients diagnosed with early untreated Lyme disease. The objective is to use the collected biological samples to help identify novel Lyme disease biomarkers that can inform diagnoses, outcomes and the knowledge about disease pathophysiology.

    Research Areas: clinical outcomes, gender differences, biomarkers, pathophysiology, immune heterogeneity, Lyme disease

    Principal Investigator

    John Aucott, M.D.

    Department

    Medicine

  • John Matthew Austin Lab

    Research in the John Matthew Austin Lab explores health care performance measures, with a goal of improving patient care by enabling healthcare providers to view data about their performance, track patient outcomes and comply with best care practices. Our lab is currently working to develop performance measures for the ICU part, and we are part of The Leapfrog Group, an annual survey of U.S. hospitals that compares hospital performance on national measures of safety, quality and efficiency. Our research also explores the use of scientifically sound decision-support tools for guiding improvements in healthcare delivery systems.

    Research Areas: health care quality, patient safety, health care performance, patient outcomes, ICU, information technology

  • John McCloskey Lab

    Research in the John McCloskey Lab focuses on quality improvements in the operating room and pediatric intensive care unit (PICU). Our work aims to improve the throughput of adolescents undergoing spinal fusions in order to better define interventions to ameliorate anesthesia emergence delirium and to improve protocols for sedation. One of our projects established an early oral feeding program for critically ill patients. Our goal is to enhance the delivery and quality of children’s health care while making it safer and more affordable.

    Research Areas: patient safety, patient outcomes, anesthesia, delirium, sedation, intensive care, pediatric critical care medicine

  • Jon Russell Lab

    The Jon Russell lab focuses on thyroid and parathyroid pathology as well as improving patient safety and education using healthcare technology. Additional focuses include utilizing new technology to advance on the techniques of minimally invasive neck surgery. Current and previous efforts include the development of mobile and web-based applications to educate physicians and patients, utilizing ultrasound for vocal cord imaging, understanding the nuances of advanced thyroid cancer, and exploring the role of scarless thyroid surgery in a North American population.

    Research Areas: patient satisfaction, thyroid cancer, perioperative information delivery, health outcomes, otolaryngology, postoperative care, endocrinology

  • Jonathan Orens Lab

    Research in the Jonathan Orens Lab examines topics such as clinical outcomes of lung transplantation, chronic allograft rejection and ischemic reperfusion injury, also known as primary graft dysfunction.

    Research Areas: ischemia-reperfusion injury, chronic allograft rejection, pulmonary medicine, lung transplant

    Principal Investigator

    Jonathan Orens, M.D.

    Department

    Medicine

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