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  • Chirag Parikh Lab

    Lab Website
    Principal Investigator:
    Chirag Parikh, M.B.B.S., Ph.D.
    Medicine

    Dr. Parikh's research focuses on the translation and validation of novel biomarkers for the dia...gnosis and prognosis of acute kidney injury. Progress in kidney diseases has been hamstrung by significant heterogeneity within the current disease definitions, which are largely based on serum creatinine. Dr. Parikh's research has addressed this critical challenge by developing biomarkers of renal tubular injury, repair, and inflammation to dissect this heterogeneity. He has assembled multicenter longitudinal prospective cohorts for translational research studies across several clinical settings of acute kidney injury and chronic kidney disease for the efficient translation of novel biomarkers.



    His research is dedicated to the process of applying discoveries generated in the laboratory and in preclinical experiments, the development of clinical studies, and the design of clinical trials. Dr. Parikh's studies have refined the clinical definition in perioperative acute kidney injury and hepatorenal syndrome, developed strategies to reduce kidney discard in deceased donor transplantation, and advanced regulatory approvals of kidney injury biomarkers. He has also developed biomarkers to identify rapid progressors of early diabetic kidney disease before derangements in serum creatinine. Dr. Parikh's research goal is to translate our understanding of pathophysiological mechanisms into clinical practice and improve the outcomes in patients with kidney disease.



    Dr. Parikh has also been the recipient of numerous honors, including the 2017 Young Investigator Award from the American Society of Nephrology.
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    Research Areas: acute kidney injury, biomarkers, Kidney Transplantation, chronic kidney disease
  • Christian Merlo Lab

    Principal Investigator:
    Christian Merlo, M.D., M.P.H.
    Medicine

    Work in the Christian Merlo Lab includes studies on pulmonary arteriovenous malformations, outc...omes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. Our recent research has also explored recipient and donor variables in the success or failure of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients. view more

    Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant
  • Christine Durand Lab

    Principal Investigator:
    Christine Durand, M.D.
    Medicine

    Dr. Christine Durand, assistant professor of medicine and oncology and member of the Johns Hopk...ins Kimmel Cancer Center, is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and HIV cure strategies including bone marrow transplantation.

    Dr. Durand is supported by multiple grants:

    • R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US.
    • K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection.
    • U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation.
    U01 from the NIAID to study HIV-to-HIV deceased donor liver transplantation.
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    Research Areas: Bone Marrow Transplantation, transplants, infectious disease, AIDS, HIV, Solid Organ Transplantation, hepatitis C
  • David Thompson Lab

    Researchers in the David Thompson Lab examine the outcomes of patients treated in intensive car...e units (ICUs), patient safety efforts, quality improvement efforts, and multidisciplinary teamwork and safety curriculum development. We're taking part in a study aimed at reducing hospital-acquired infections among cardiovascular surgery patients. Our investigators also participated in a clinical research collaboration that saw an 81 percent reduction in bloodstream infections related to central lines. view more

    Research Areas: medical education, patient safety, quality improvement, infections, patient outcomes, ICU
  • Deidra Crews Lab

    Principal Investigator:
    Deidra Crews, M.D.
    Medicine

    Dr. Crews’ team focuses on health disparities in chronic kidney disease. We have studied how so...cial determinants of health, such as poverty and healthful food access, affect disparities in kidney disease outcomes. Our research on end-stage renal disease includes studies of the best timing and environment to initiate dialysis among vulnerable populations. view more

    Research Areas: poverty, chronic kidney disease, health disparities
  • Donald Shaffner Lab

    Work in the Donald Shaffner Lab investigates several topics within critical care medicine. Our ...team conducts research on the mechanisms involved in neurologic injury from global ischemia as a result of cardiac arrest and resuscitation. We also study neurologic outcomes of pediatric patients who experience cardiac arrest. view more

    Research Areas: hyperthermia, critical care medicine, cardiac arrest, resuscitation, ischemia, pediatrics, neurology
  • Elizabeth Daugherty Lab

    The Elizabeth Daugherty Lab conducts research on patient safety, critical care infection contro...l and critical care disaster response. We investigate methods of improving patient safety through improved infection control, with a focus on clinical outcomes, nosocomial infection rates and the individual and organizational obstacles to personal protective equipment adherence. view more

    Research Areas: critical care medicine, patient safety, infection control, nosocomial infections
  • Elizabeth Hunt Lab

    Researchers in the Elizabeth Hunt Lab study innovative ways to improve the care quality and cli...nical outcomes of children who suffer cardiopulmonary arrest. Our work includes implementing rapid-response systems, capturing and analyzing cardiac-arrest data, and redesigning medical devices and simulators. We've introduced novel simulation approaches to education, including data-driven debriefing and the Rapid Cycle Deliberate Practice approach. view more

    Research Areas: outcomes, pediatric cardiopulmonary arrest, rapid response systems, rapid cycle deliberate practice, pediatrics, quality of care
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