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Research Lab Results for organs

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  • Brendan Cormack Laboratory

    The Brendan Cormack Laboratory studies fungal pathogenesis, particularly the host-pathogen inte...raction for the yeast pathogen Candida glabrata.

    We are trying to identify virulence genes (genes that evolved in response to the host environment) by screening transposon mutants of C. glabrata for mutants that are specifically altered in adherence to epithelial cells, in survival in the presence of macrophages and PMNs. We also screen mutants directly in mice for those unable to colonize or persist in the normal target organs (liver, kidney and spleen).

    We also focus research on a family of genes--the EPA genes--that allow the organism to bind to host cells. Our research shows that a subset of them are able to mediate adherence to host epithelial cells. We are trying to understand the contribution of this family to virulence in C. glabrata by figuring out what the ligand specificity is of different family members, how genes are normally regulated during infection, and what mechanisms normally act to keep the genes transcriptionally silent and how that silence is regulated.
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    Research Areas: candida glabrata, pathogenesis, virulence genes, yeast, molecular biology
  • Christine Durand Lab

    Principal Investigator:
    Christine Durand, M.D.
    Medicine

    Dr. Christine Durand, assistant professor of medicine and oncology and member of the Johns Hopk...ins Kimmel Cancer Center, is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and HIV cure strategies including bone marrow transplantation.

    Dr. Durand is supported by multiple grants:

    • R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US.
    • K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection.
    • U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation.
    U01 from the NIAID to study HIV-to-HIV deceased donor liver transplantation.
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    Research Areas: Bone Marrow Transplantation, transplants, infectious disease, AIDS, HIV, Solid Organ Transplantation, hepatitis C
  • Clemens Lab

    Lab Website
    Principal Investigator:
    Thomas Clemens, Ph.D.
    Orthopaedic Surgery

    Research in the Clemens Lab focuses on identification of the cellular and molecular mechanisms ...that mediate bone formation and repair. Currently, we are studying the role of sensory nerves in bone and the coupling of bone cell metabolic activity to the sensory nerves' development and function.

    The skeleton is one of the most important structures in our bodies. Bones allow us to stand, walk and move from one place to another, and they serve as protectors of our vital organs. With aging, our skeleton both loses its bone mineral and the structure (micro-architecture). The fine trabecular bone is organized into plates and rods, and these structures develop cracks and discontinuity. As we age, bone is lost and its structure compromised. This degradation of our bone structure — osteoporosis — is a global health problem. Thomas Clemens, M.D. is the director of the Clemens lab. He is the Lewis Cass Spencer professor of orthopaedic surgery and the vice chair for research in the Department of Orthopaedic Surgery at Johns Hopkins.
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    Research Areas: osteoporosis, orthopaedics, sensory nerves, osteopenia, bone disease, bone repair
  • Kunisaki Lab

    Principal Investigator:
    Shaun Kunisaki, M.D., M.Sc.
    Surgery

    The Kunisaki lab is a R01-funded regenerative medicine group within the Division of General ...Pediatric Surgery at Johns Hopkins that works at the interface of stem cells, mechanobiology, and materials science. We seek to understand how biomaterials and mechanical forces affect developing tissues relevant to pediatric surgical disorders. To accomplish these aims, we take a developmental biology approach using induced pluripotent stem cells and other progenitor cell populations to understand the cellular and molecular mechanisms by which fetal organs develop in disease.


    Our lab projects can be broadly divided into three major areas: 1) fetal spinal cord regeneration 2) fetal lung development 3) esophageal regeneration


    Lab members: Juan Biancotti, PhD (lab manager); Lynn Zhou, PhD (postdoc), Shelby Sferra, MD, MPH (postdoc); Annalise Penikis, MD (postdoc)


    Recent publications:
    Kunisaki SM, Jiang G, Biancotti JC, Ho KKY, Dye BR, Liu AP, Spence JR. Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of congenital diaphragmatic hernia fetal lung. Stem Cells Translational Medicine 2021, PMID: 32949227


    Biancotti JC, Walker KA, Jiang G, Di Bernardo J, Shea LD, Kunisaki SM. Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in an ex vivo model of prenatal spina bifida repair. Journal of Tissue Engineering 2020, PMID: 32782773.


    Kunisaki SM. Amniotic fluid stem cells for the treatment of surgical disorders in the fetus and neonate. Stem Cells Translational Medicine 2018, 7:767-773

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    Research Areas: fetal therapy, stem cells, pediatric surgery, tissue engineering, congenital diaphragmatic hernia, myelomeningocele
  • Molecular Mechanisms of Cellular Mechanosensing (Robinson Lab)

    Lab Website

    The Robinson Lab studies the way in which mechanical stress guide and direct the behavior of ce...lls, including when they are part of tissues, organs and organ systems. view more

    Research Areas: cellular mechanosensing, tissues, organs, molecular biology
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