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Research Lab Results for obesity

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  • Roberto Salvatori Lab

    Principal Investigator:
    Roberto Salvatori, M.D.
    Medicine

    Research in the Roberto Salvatori Lab focuses on the genetic causes of isolated growth hormone ...deficiency (GHD), consequences of untreated GHD, and cortisol excess and deficiency. Current work explores GHD’s relation to obesity and indicates that Cushing's syndrome may be under-recognized in patients undergoing bariatric surgery. We recently took part in a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients, a condition that has not been studied previously in a standardized way. view more

    Research Areas: pituitary gigantism, growth hormone deficiency, hypercortisolism, endocrinology
  • The Barouch Lab

    Principal Investigator:
    Lili Barouch, M.D.
    Medicine

    The Barouch Lab is focused on defining the peripheral cardiovascular effects of the adipocytoki...ne leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program will enhance the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular function.

    The lab also is working to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work will enable the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.

    Lili Barouch, MD, is an associate professor of medicine in the Division of Cardiology and a member of the Advanced Heart Failure and Cardiac Transplantation group at the Johns Hopkins University School of Medicine.
    view more

    Research Areas: cardiac remodeling, cardiac hypertrophy, obesity, cognitive heart failure
  • Vsevolod Polotsky Lab

    Principal Investigator:
    Vsevolod Polotsky, M.D., Ph.D.
    Medicine

    The Vsevolod Polotsky Lab conducts research on pulmonary diseases, including hypoxia and sleep ...apnea, with a focus on their relation to obesity and metabolic syndrome. Our studies have explored topics such as the effects of age, leptin and obesity on the upper airway; the relationship between obstructive sleep apnea, insulin resistance and steatohepatitis in severely obese patients; and the impact of intermittent hypoxia on diet-induced obesity. We also have a long-standing interest in critical care pulmonary medicine and have conducted research on various aspects of murine lung injury. view more

    Research Areas: critical care medicine, obesity, pulmonary medicine, obstructive sleep apnea, lung disease, metabolic syndrome, hypoxia
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