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Displaying 11 to 20 of 20 results for obesity

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  • Nicola Heller Lab

    Research in the Nicola Heller Lab focuses on the immunobiology of macrophages. Our team explores how these cells impact diseases with an inflammatory element, such as cancer, cardiovascular disease and obesity. Using a variety of techniques, including molecular and cellular biology, biochemistry, mouse models and more, we study the role of IL-4/IL-13 signaling in asthma and allergic disease, as well as the role of alternatively activated macrophages (AAM) in the pathogenesis of allergic inflammation. Currently, we are researching the links between asthma and obesity, with a focus on the roles of gender and race.

    Research Areas: asthma, allergies, immunobiology, inflammation, macrophages

  • Nisa Maruthur Lab

    The Nisa Maruthur Lab studies primary care; individualized medicine for the prevention and treatment of type 2 diabetes and obesity; pharmacogenomics of type 2 diabetes; and comparative effectiveness.

    Research Areas: primary care, obesity, pharmacogenomics, diabetes

    Principal Investigator

    Nisa Maruthur, M.D., M.H.S.

    Department

    Medicine

  • Philip Smith Lab

    Work in the Philip Smith Lab explores several key topics within the field of sleep medicine. We investigate the role of obesity and neural control in sleep-disordered breathing as well as the impact of metabolic function on sleep apnea. We also research the ways in which HIV and its treatments impact a patient’s sleep. Our studies have included the effects of HIV and highly active antiretroviral therapy (HAART) on both sleep and daytime function as well as the relationship between systemic inflammation and sleep apnea in men with HIV.

    Research Areas: AIDS, sleep medicine, obesity, HIV, metabolic function, sleep apnea

    Principal Investigator

    Philip Smith, M.D.

    Department

    Medicine

  • Roberto Salvatori Lab

    Research in the Roberto Salvatori Lab focuses on the genetic causes of isolated growth hormone deficiency (GHD), consequences of untreated GHD, and cortisol excess and deficiency. Current work explores GHD’s relation to obesity and indicates that Cushing's syndrome may be under-recognized in patients undergoing bariatric surgery. We recently took part in a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients, a condition that has not been studied previously in a standardized way.

    Research Areas: pituitary gigantism, growth hormone deficiency, hypercortisolism, endocrinology

    Principal Investigator

    Roberto Salvatori, M.D.

    Department

    Medicine

  • Sheng Wu Laboratory

    The Sheng Wu Laboratory studies the insulin/androgen receptor (AR) actions on the developmental and regulation of the reproductive and metabolic functions. We use multiple animal models (obesity, androgen implantation, and conditional knockout) to investigate the pathophysiology of polycystic ovarian syndrome (PCOS) and the developmental factors and their target tissues that contribute to PCOS manifestation.

    Research Areas: reproduction, insulin, polycystic ovarian syndrome, endocrinology, androgen receptor

    Principal Investigator

    Sheng Wu, M.Sc., Ph.D.

    Department

    Pediatrics

  • Susheel Patil Lab

    Research in the Susheel Patil Lab focuses on the origination and development obstructive sleep apnea (OSA). Specifically, we’re interested in how obesity, adipokines and inflammation affect mechanisms that contribute to upper airway collapsibility. We’ve studied various patient groups affected by OSA, including patients who've had bariatric surgery, are HIV-infected or have non-alcoholic fatty liver disease.

    Research Areas: upper airway obstruction, pulmonary medicine, pathogenesis, sleep apnea

    Principal Investigator

    Susheel Patil, M.D., Ph.D.

    Department

    Medicine

  • The Barouch Lab

    The Barouch Lab is focused on defining the peripheral cardiovascular effects of the adipocytokine leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program will enhance the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular function.

    The lab also is working to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work will enable the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.

    Lili Barouch, MD,... is an associate professor of medicine in the Division of Cardiology and a member of the Advanced Heart Failure and Cardiac Transplantation group at the Johns Hopkins University School of Medicine. view more

    Research Areas: cardiac remodeling, cardiac hypertrophy, obesity, cognitive heart failure

    Principal Investigator

    Lili Barouch, M.D.

    Department

    Medicine

  • The Hamad Lab

    Our research interest is crystalized into three main areas:
    1. Type-1 diabetes - Our focus is on understanding how the Fas death pathway regulates the disease and how extracted information can be used to protect high risk individuals and those with new-onset disease.
    2. Type 2 diabetes and Obesity - Our lab is studying the role of heparan sulfate proteoglycans (HSPG) in regulating body fat and glucose clearance.
    3. Double negative ??T cells - Our studies suggest a critical role for these cells in protecting kidneys from Ischemia reperfusion injury (IRI). Our current focus is understanding their origin and physiological functions.

    Research Areas: type 1 diabetes, type 2 diabetes, obesity, Double negative alpha/beta T cells, T cells

    Lab Website

    Principal Investigator

    Abdel-Rahim Hamad, M.V.Sc., Ph.D.

    Department

    Pathology

  • Vsevolod Polotsky Lab

    The Vsevolod Polotsky Lab conducts research on pulmonary diseases, including hypoxia and sleep apnea, with a focus on their relation to obesity and metabolic syndrome. Our studies have explored topics such as the effects of age, leptin and obesity on the upper airway; the relationship between obstructive sleep apnea, insulin resistance and steatohepatitis in severely obese patients; and the impact of intermittent hypoxia on diet-induced obesity. We also have a long-standing interest in critical care pulmonary medicine and have conducted research on various aspects of murine lung injury.

    Research Areas: critical care medicine, obesity, pulmonary medicine, obstructive sleep apnea, lung disease, metabolic syndrome, hypoxia

    Principal Investigator

    Vsevolod Polotsky, M.D., Ph.D.

    Department

    Medicine

  • Zhiping Li Lab

    The Zhiping Li Lab focuses on the pathogenesis of nonalcoholic fatty liver disease and immune-mediated liver injury. Our active research focuses on the dietary modulation of gut bacteria, liver innate immune system and their regulation on tissue injury and repair. Clinical research from the lab focuses on cirrhotic ascites, liver transplant, hepatocellular carcinoma and immune-mediated liver diseases as well as endoscopic techniques and interventions.

    Research Areas: gastrointestinal system, gut bacteria, nutrition, obesity, pathogenesis, liver diseases

    Principal Investigator

    Zhiping Li, M.D.

    Department

    Medicine

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