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Displaying 11 to 20 of 30 results for neuroscience

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  • Glowatzki Lab

    Research in the Glowatzki Lab focuses on the auditory system, with a particular focus on synaptic transmission in the inner ear.

    Our lab is using dendritic patch clamp recordings to examine mechanisms of synaptic transmission at this first, critical synapse in the auditory pathway. With this technique, we can diagnose the molecular mechanisms of transmitter release at uniquely high resolution (this is the sole input to each afferent neuron), and relate them directly to the rich knowledge base of auditory signaling by single afferent neurons.

    We study pre- and post-synaptic mechanisms that determine auditory nerve fiber properties. This approach will help to study general principles of synaptic transmission and specifically to identify the molecular substrates for inherited auditory neuropathies and other cochlear dysfunctions.

    Research Areas: synaptic transmission, auditory synapses, inner ear, neurotransmitters, inherited auditory neuropathy, cochlear dysfunctions, otolaryngology, audiology, neuroscience, sound

  • Jantzie Lab

    Dr. Jantzie, associate professor, received her Ph.D. in Neurochemistry from the University of Alberta in 2008. In 2013 she completed her postdoctoral fellowship in the Department of Neurology at Boston Children's Hospital & Harvard Medical School and became faculty at the University of New Mexico. Dr. Jantzie then joined the faculty Departments of Pediatrics (Neonatal-Perinatal Medicine) and Neurology at Johns Hopkins University and the Kennedy Krieger Institute in January 2019. Her lab investigates the pathophysiology of encephalopathy of prematurity, and pediatric brain injury common to infants and toddlers. Dr. Jantzie is dedicated to understanding disease processes in the developing brain as a means to identifying new therapeutic strategies and treatment targets for perinatal brain injury. Her lab studies neural substrates of cognition and executive function, inhibitory circuit formation, the role of an abnormal intrauterine environment on brain development, mechanisms of neurorepa...ir and microglial activation and polarization. Using a diverse array of clinically relevant techniques such as MRI, cognitive assessment, and biomarker discovery, combined with traditional molecular and cellular biology, the Jantzie lab is on the front lines of translational pediatric neuroscience.? view less

    Research Areas: Neonatology, neuroscience

    Principal Investigator

    Lauren Jantzie, Ph.D.

    Department

    Pediatrics

  • Jeremy Nathans Laboratory

    The Jeremy Nathans Laboratory is focused on neural and vascular development, and the role of Frizzled receptors in mammalian development. We use gene manipulation in the mouse, cell culture models, and biochemical reconstitution to investigate the relevant molecular events underlying these processes, and to genetically mark and manipulate cells and tissues. Current experiments are aimed at defining additional Frizzled-regulated processes and elucidating the molecular mechanisms and cell biologic results of Frizzled signaling within these various contexts. Complementing these areas of biologic interest, we have ongoing technology development projects related to genetically manipulating and visualizing defined cell populations in the mouse, and quantitative analysis of mouse visual system function.

    Research Areas: vascular development, biochemistry, cell biology, neurodevelopment, genomics, Frizzled receptors, neuroscience

  • Kata Design Studio

    We started Kata to bridge the gap between professional experiential production and neuroscience, clinical neurology, and medical hardware. We strive to build experiences and technology from the ground up, with a focus on mission, and at a level that is consistent with the best productions in the industry. We mirror the thousands of hours that go into a level design in a video game, but with the crucial difference that the focus is on the subtleties required for patient treatment or wellness. Our designs require high-frequency iterative development with patients and users in countless game-play sessions in which they provide crucial feedback. Characters have been painstakingly crafted to elicit profound emotional responses. Some of the requirements for patients or the elderly population in this space are qualitatively different from what is needed in the entertainment marketplace. That said we have also understood the critical artistic similarities.

    The core ethos of Kata is that the... challenge of complex movement has profound benefits for cognition, wellness, and brain repair. Specifically, there is growing evidence that complex motor movement can have cognitive benefits that go beyond what has been reported for exercise alone. When designing experiences to treat motor impairments after stroke, maximizing rigorous and dynamic motor input is a requirement. New interactive technologies will allow people to engage in diverse and complex motor movements, even in the home, which was previously impossible.

    Overall it has been a very exciting journey, combining art, medicine, technology, and neuroscience. We continue to build, discover, and craft immersive experiences, side by side with physicians, physical therapists, and scientists, with the common goal of pushing clinical care and wellness forward. We believe this is only possible by having a mission focused design group embedded in an academic hospital. Ultimately, we wish to scale and perfect these innovations into other hospitals. Kata is a true hybrid of academia, and industry, doing what neither can do in isolation. We hope the ethos and design philosophy behind Kata provides the impetus for its expansion, partnerships, and growth.
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    Research Areas: ALS, stroke, vestibular disorders

    Lab Website

    Principal Investigator

    John Krakauer, M.A., M.D.

    Department

    Neurology

  • Kathleen Cullen Lab

    We are continually in motion. This self-motion is sensed by the vestibular system, which contributes to an impressive range of brain functions, from the most automatic reflexes to spatial perception and motor coordination. The objective of Dr. Cullen's lab's research program is to understand the mechanisms by which self-motion (vestibular) information is encoded and then integrated with signals from other modalities to ensure accurate perception and control of gaze and posture. Our studies investigate the sensorimotor transformations required for the control of movement, by tracing the coding of vestibular stimuli from peripheral afferents, to behaviorally-contingent responses in central pathways, to the readout of accurate perception and behavior. Our experimental approach is multidisciplinary and includes a combination of behavioral, neurophysiological and computational approaches in alert behaving non-human primates and mice. Funding for the laboratory has been and is provided by th...e Canadian Institutes for Health Research (CIHR), The National Institutes of Health (NIH), the National Sciences and Engineering Research Council of Canada (NSERC), FQRNT / FQRSC (Quebec). view more

    Research Areas: otolaryngology, biomedical engineering, surgery, neuroscience

  • Kechen Zhang Laboratory

    The research in the Kecken Zhang Laboratory is focused on theoretical and computational neuroscience. We use mathematical analysis and computer simulations to study the nervous system at multiple levels, from realistic biophysical models to simplified neuronal networks. Several of our current research projects involve close collaborations with experimental neuroscience laboratories.

    Research Areas: biophysics, neuroscience, neuronal networks, nervous system

    Lab Website

    Principal Investigator

    Kechen Zhang, Ph.D.

    Department

    Biomedical Engineering

  • Laboratory for Computational Motor Control

    The Laboratory for computational Motor Control studies movement control in humans, including healthy people and people with neurological diseases. We use robotics, brain stimulation and neuroimaging to study brain function. Our long-term goals are to use mathematics to understand: 1) the basic function of the motor structures of the brain including the cerebellum, the basal ganglia and the motor cortex; and 2) the relationship between how our brain controls our movements and how it controls our decisions.

    Research Areas: robotics, brain, movement, mathematics, neuroscience, decision making

  • Marvel Cognitive Neuropsychiatric Research Laboratory

    The Cognitive Neuropsychiatric Research Laboratory (CNRLab) is part of the Division of Cognitive Neuroscience within the Department of Neurology at the Johns Hopkins University School of Medicine. Its current projects include investigating the motor system's contribution to cognitive function; HIV-related neuroplasticity and attention-to-reward as predictors of real world function; and brain function and cognition in Lyme disease.

    Research Areas: HIV, neuroplasticity, movement disorders, cognitive function

    Lab Website

    Principal Investigator

    Cherie Marvel, Ph.D.

    Department

    Neurology

  • Neuroengineering and Biomedical Instrumentation Lab

    The mission and interest of the neuroengineering and Biomedical Instrumentation Lab is to develop novel instrumentation and technologies to study the brain at several levels--from single cell to the whole brain--with the goal of translating the work into practical research and clinical applications.

    Our personnel include diverse, independent-minded and entrepreneurial students, post docs, and research faculty who base their research on modern microfabrication, stem cell biology, electrophysiology, signal processing, image processing, and integrated circuit design technologies.

    Research Areas: stem cells, imaging, brain, electrophysiology, neuroengineering, biomedical engineering, neuroscience

    Lab Website

    Principal Investigator

    Nitish Thakor, Ph.D.

    Department

    Biomedical Engineering

  • Neuroimaging and Modulation Laboratory (NIMLAB)

    The neuroimaging and Modulation Laboratory (NIMLAB) investigates neural correlates of cognition and behavior using neuroimaging methods such as functional magnetic resonance imaging (fMRI) and neuromodulation techniques such as transcranial magnetic stimulation (TMS). We are looking in depth at the contributions of the cerebellum and cerebro-cerebellar circuits to cognition; the effects of chronic heavy alcohol consumption on cognition and brain activation underlying cognitive function; how aging in humans affects neural systems that are important for associative learning and stimulus awareness; and the integration of transcranial magnetic stimulation with functional MRI.

    Research Areas: cognition, alcohol, functional magnetic resonance imaging, imaging, aging, neuroscience, neuroimaging, transcranial magnetic stimulation

    Lab Website

    Principal Investigator

    John Desmond, M.S., Ph.D.

    Department

    Neurology

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