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Displaying 1 to 4 of 4 results for neurodevelopment

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  • Alex Kolodkin Laboratory

    Research in the Alex Kolodkin Laboratory is focused on understanding how neuronal connectivity is established during development. Our work investigates the function of extrinsic guidance cues and their receptors on axonal guidance, dendritic morphology and synapse formation and function. We have investigated how neural circuits are formed and maintained through the action of guidance cues that include semaphorin proteins, their classical plexin and neuropilin receptors, and also novel receptors. We employ a cross-phylogenetic approach, using both invertebrate and vertebrate model systems, to understand how guidance cues regulate neuronal pathfinding, morphology and synaptogenesis. We also seek to understand how these signals are transduced to cytosolic effectors. Though broad in scope, our interrogation of the roles played by semaphorin guidance cues provides insight into the regulation of neural circuit assembly and function. Our current work includes a relatively new interest in ...understanding the origins of laminar organization in the central nervous system. view more

    Research Areas: central nervous system, neural circuits, neurodevelopment, neuronal connectivity, laminar organization

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    Principal Investigator

    Alex Kolodkin, Ph.D.



  • Brady Maher Laboratory

    The Brady Maher Laboratory is interested in understanding the cellular and circuit pathophysiology that underlies neurodevelopmental and psychiatric disorders. Our lab focuses on trying to understand the function of genes that are associated with neurodevelopment problems by manipulating their expression level in utero during the peak of cortical development. We then use a variety of approaches and technologies to identify resulting phenotypes and molecular mechanisms including cell and molecular biology, optogenetics, imaging and electrophysiology.

    Current projects in the lab are focused on understanding the function of transcription factor 4 (TCF4), a clinically pleiotropic gene. Genome-wide association studies have identified genetic variants of TCF4 that are associated with schizophrenia, while autosomal dominant mutations in TCF4 result in Pitt Hopkins syndrome. Using our model system, we have identified several interesting electrophysiological and cell biological phenotypes as...sociated with altering the expression of TCF4 in utero. We hypothesize that these phenotypes represent cellular pathophysiology related to these disorders and by understanding the molecular mechanisms responsible for these phenotypes we expect to identify therapeutic targets for drug development.
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    Research Areas: cell biology, neurodevelopment, imaging, schizophrenia, psychiatric disorders, Pitt Hopkins syndrome, elecrophysiology, genomics, drugs, optogenetics, molecular biology, phenotypes

  • Jeremy Nathans Laboratory

    The Jeremy Nathans Laboratory is focused on neural and vascular development, and the role of Frizzled receptors in mammalian development. We use gene manipulation in the mouse, cell culture models, and biochemical reconstitution to investigate the relevant molecular events underlying these processes, and to genetically mark and manipulate cells and tissues. Current experiments are aimed at defining additional Frizzled-regulated processes and elucidating the molecular mechanisms and cell biologic results of Frizzled signaling within these various contexts. Complementing these areas of biologic interest, we have ongoing technology development projects related to genetically manipulating and visualizing defined cell populations in the mouse, and quantitative analysis of mouse visual system function.

    Research Areas: vascular development, biochemistry, cell biology, neurodevelopment, genomics, Frizzled receptors, neuroscience

  • Keri Martinowich Laboratory

    Neural plasticity allows for physiological changes in the brain during both development and in adulthood. The Keri Martinowich Laboratory studies how specific forms of plasticity contribute to regulation of circuits that mediate complex brain function and behavior in order to define how deficits in these processes lead to psychiatric and neurodevelopmental disorders. Current projects focus on brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family implicated in survival, maturation and differentiation of numerous cell types, synaptogenesis and regulation of dendritic morphology. BDNF is a key regulator of synaptic plasticity both in the developing and adult brain. These studies aim to contribute to the long-term goal of understanding how neural plasticity contributes to the function of circuits mediating complex brain function and behavior.

    Research Areas: brain-derived neurotrophic factor (BDNF), neurodevelopment, brain, neural plasticity, mental illness

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