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Displaying 1 to 11 of 11 results for neurobiology

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  • Daniel Weinberger Laboratory

    The Daniel Weinberger Laboratory focuses on the neurobiological mechanisms of genetic risk for developmental brain disorders. We study the genetic regulation of the transcriptome in normal human brain across the human life span and in brains from patients with various psychiatric disorders. We also study the impact of genetic variation on aspects of human brain development and function linked with risk for schizophrenia and related psychiatric disorders. Our lab uses unique molecular and clinical datasets and biological materials from a large sample of families with affected and unaffected offspring and normal volunteers. These datasets include DNA, lymphoblast and fibroblast cell lines, and extensive quantitative phenotypes related to genetic risk for schizophrenia, including detailed cognitive assessments and various neuroimaging assays. In other research, we are working on a human brain transcriptome project that is RNA sequencing over 1,000 human brain samples in various regi...ons and based also on sorting of specific celliular phentypes. We are exploring the molecular processing of the gene and its implications for cognition and aspects of human temperament. view more

    Research Areas: neurobiology, brain, transcriptome, schizophrenia, psychiatric disorders, genomics, developmental disorders, RNA

  • David Linden Lab

    The David Linden Laboratory has used both electrode and optical recording in cerebellar slice and culture model systems to explore the molecular requirements for induction and expression of these phenomena. Along the way, we discovered a new form of plasticity. In addition, we have expanded our analysis to include use-dependent synaptic and non-synaptic plasticity in the cerebellar output structure, the deep nuclei.

    Our investigations are central to understanding the cellular substrates of information storage in a brain area where the behavioral relevance of the inputs and outputs is unusually well defined. In addition, our investigations have potential clinical relevance for cerebellar motor disorders and for disorders of learning and memory generally.

    Research Areas: motor learning, synaptic plasticity, neurobiology, memory, cerebellum, brain

    Principal Investigator

    David Linden, Ph.D.

    Department

    Neuroscience

  • Erwin Lab

    Schizophrenia, autism and other neurological disorders are caused by a complex interaction between inherited genetic risk and environmental experiences. The overarching goal of the group are to reveal molecular mechanisms of gene by environment interactions related to altered neural development and liability for brain disorders. Our research uses a hybrid of human stem cell models, post-mortem tissue and computational approaches to interrogate the contribution of epigenetic regulation and somatic mosaicism to brain diseases. Our previous work has demonstrated that the human brain exhibits extensive genetic variability between neurons within the same brain, termed "somatic mosaicism" due to mobile DNA elements which mediate large somatic DNA copy number variants. We study environment-responsive mechanisms and consequences for somatic mosaicism and are discovering the landscape of somatic mosaicism in the brain. We also study the epigenetic regulation of cell specification and activity-d...ependent states within the human dorsal lateral prefrontal cortex and striatum. view more

    Research Areas: autism, Cellular and Molecular Neuroscience, stem cells, Developmental Neuroscience, Neurobiology of Disease, Induced Pluripotent Stem Cell Models, Organoids, schizophrenia, genomics, Dystonia, Epigenomics

    Lab Website

    Principal Investigator

    Jennifer Erwin, Ph.D.

    Department

    Neurology

  • Gary Wand Lab

    Research conducted in the Gary Wand Lab focuses on neuropsychoendocrinology; the neurobiology of substance abuse; physiogenetics and regulation of the stress response; and the relationship between stress and chemical dependency. Current studies seek to better understand the genetic determinants of the stress response and how excessive stress hormone production contributes to neurobiological disorders, including addiction.

    Research Areas: neurobiology, substance abuse, stress, hormones, physiogenetics, neuropsychoendocrinology, alcoholism

    Principal Investigator

    Gary Wand, M.D.

    Department

    Medicine

  • Haughey Lab: Neurodegenerative and Neuroinfectious Disease

    Dr. Haughey directs a disease-oriented research program that address questions in basic neurobiology, and clinical neurology. The primary research interests of the laboratory are:

    1. To identify biomarkers markers for neurodegenerative diseases including HIV-Associated Neurocognitive Disorders, Multiple Sclerosis, and Alzheimer’s disease. In these studies, blood and cerebral spinal fluid samples obtained from ongoing clinical studies are analyzed for metabolic profiles through a variety of biochemical, mass spectrometry and bioinformatic techniques. These biomarkers can then be used in the diagnosis of disease, as prognostic indicators to predict disease trajectory, or as surrogate markers to track the effectiveness of disease modifying interventions.
    2. To better understand how the lipid components of neuronal, and glial membranes interact with proteins to regulate signal transduction associated with differentiation, motility, inflammatory signaling, survival, and neuronal excitab...ility.
    3. To understand how extracellular vesicles (exosomes) released from brain resident cells regulate neuronal excitability, neural network activity, and peripheral immune responses to central nervous system damage and infections.
    4. To develop small molecule therapeutics that regulate lipid metabolism as a neuroprotective and restorative strategy for neurodegenerative conditions.
    view more

    Research Areas: multiple sclerosis, PTSD, HAND, HIV

    Lab Website

    Principal Investigator

    Norman Haughey, Ph.D.

    Department

    Neurology
    Neurosurgery

  • Mikhail Pletnikov Laboratory

    The Mikhail Pletnikov Laboratory is interested in the neurobiology of neurodevelopmental diseases such as schizophrenia and autism. The major focus of our laboratory is to evaluate how adverse environmental factors and vulnerable genes interact to affect brain and behavior development. We address these experimental questions by using methods of cell and molecular biology, neuroimmunology, neurochemistry, psychopharmacology and developmental psychobiology. The current projects in our laboratory are: (1) Genetic risk factors in neuron-astrocyte interaction during neurodevelopment, (2) Gene-environment interplay in the pathogenesis of psychiatric conditions, and (3) The neuroimmune interactions in abnormal neurodevelopment

    Research Areas: autism, immunology, neurobiology, cell biology, neurodevelopment, developmental psychobiology, schizophrenia, pharmacology, chemistry, molecular biology

  • S.C.O.R.E. Lab

    The mission of the Stroke Cognitive Outcomes and Recovery (S.C.O.R.E.) Lab is to enhance knowledge of brain mechanisms that allow people recover language, empathy, and other cognitive and communicative functions after stroke, and to improve ways to facilitate recovery of these functions after stroke. We also seek to improve the understanding of neurobiology of primary progressive aphasia., and how to enhance communication in people with this group of clinical syndromes.

    Research Areas: cerebrovascular, cognitive neuroscience, dementia

    Lab Website

    Principal Investigator

    Argye Hillis, M.D.

    Department

    Neurology

  • Systems Neurobiology Laboratory

    The Systems neurobiology Laboratory is a group of laboratories that all study various aspects of neurobiology. These laboratories include: (1) computational neurobiology Laboratory: The goal of their research is to build bridges between brain levels from the biophysical properties of synapses to the function of neural systems. (2) computational Principles of Natural Sensory Processing: Research in this lab focuses on the computational principles of how the brain processes information. (3) Laboratory for Cognitive neuroscience: This laboratory studies the neural and genetic underpinnings of language and cognition. (4) Sloan-Swartz Center for Theoretical neurobiology: The goal of this laboratory is develop a theoretical infrastructure for modern experimental neurobiology. (5) Organization and development of visual cortex: This laboratory is studying the organization and function of neural circuits in the visual cortex to understand how specific neural components enable visual perception ...and to elucidate the basic neural mechanisms that underlie cortical function. (6) Neural mechanism of selective visual attention: This laboratory studies the neural mechanisms of selective visual attention at the level of the individual neuron and cortical circuit, and relates these findings to perception and conscious awareness. (7) Neural basis of vision: This laboratory studies how sensory signals in the brain become integrated to form neuronal representation of the objects that people see. view more

    Research Areas: cognition, systems biology, brain, vision, neuroscience, perception

  • The Pathak Lab

    The Pathak lab is within the Division of Cancer Imaging Research in the Department of Radiology and Radiological Science. We develop novel imaging methods, computational models and visualization tools to ‘make visible’ critical aspects of cancer, stroke and neurobiology. Our research broadly encompasses the following areas: Functional and Molecular Imaging; Clinical Biomarker Development; Image-based Systems Biology and Visualization and Computational Tools. We are dedicated to mentoring the next generation of imagers, biomedical engineers and visualizers. Additional information can be found at www.pathaklab.org or by emailing Dr. Pathak.

    Research Areas: microscopy, vasculature, tumors, systems biology, functional magnetic resonance imaging, 3D imaging, biomarkers, optical imaging, angiogenesis, cancer imaging

  • Translational Neurobiology Laboratory

    The goals of the Translational neurobiology Laboratory are to understand the pathogenesis and cell death pathways in neurodegenerative disorders to reveal potential therapeutic targets for pharmaceutical intervention; to investigate endogenous survival pathways and try to induce these pathways to restore full function or replace lost neurons; and to identify biomarkers to mark disease function or replace lost neurons; and to identify biomarkers to mark disease progression and evaluate therapeutics. Our research projects focus on models of Huntington's disease and Parkinson's disease. We use a combination of cell biology and transgenic animal models of these diseases.

    Research Areas: Huntington's disease, neurodegenerative disorders, neurobiology, cell biology, Parkinson's disease

  • Yun Guan Lab

    Research is the Yun Guan Lab explores the peripheral, spinal and supraspinal mechanisms of chronic pain. Our long-term goal is to develop better strategies and novel targets for treatment of pathological pain conditions. Our team’s multidisciplinary research uses electrophysiological, molecular biological, immunocytochemical and behavioral pharmacological approaches to study neurobiological mechanisms of pain and hyperalgesia that occur following tissue or nerve injury.

    Research Areas: neurobiology, pain, hyperalgesia

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