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Research Lab Results for nervous system

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  • Albert Lau Lab

    Lab Website
    Principal Investigator:
    Albert Lau, Ph.D.
    Biophysics and Biophysical Chemistry

    The Lau Lab uses a combination of computational and experimental approaches to study the atomic... and molecular details governing the function of protein complexes involved in intercellular communication. We study ionotropic glutamate receptors (iGluRs), which are ligand-gated ion channels that mediate the majority of excitatory synaptic transmission in the central nervous system. iGluRs are important in synaptic plasticity, which underlies learning and memory. Receptor dysfunction has been implicated in a number of neurological disorders. view more

    Research Areas: central nervous system, synaptic plasticity, computational biology, intracellular communication, ionotropic glutamate receptors, neurological disorders
  • Alex Kolodkin Laboratory

    Lab Website
    Principal Investigator:
    Alex Kolodkin, Ph.D.
    Neuroscience

    Research in the Alex Kolodkin Laboratory is focused on understanding how neuronal connectivity ...is established during development. Our work investigates the function of extrinsic guidance cues and their receptors on axonal guidance, dendritic morphology and synapse formation and function. We have investigated how neural circuits are formed and maintained through the action of guidance cues that include semaphorin proteins, their classical plexin and neuropilin receptors, and also novel receptors. We employ a cross-phylogenetic approach, using both invertebrate and vertebrate model systems, to understand how guidance cues regulate neuronal pathfinding, morphology and synaptogenesis. We also seek to understand how these signals are transduced to cytosolic effectors. Though broad in scope, our interrogation of the roles played by semaphorin guidance cues provides insight into the regulation of neural circuit assembly and function. Our current work includes a relatively new interest in understanding the origins of laminar organization in the central nervous system. view more

    Research Areas: central nervous system, neural circuits, neurodevelopment, neuronal connectivity, laminar organization
  • Allan Gottschalk Lab

    Research in the Allan Gottschalk Lab focuses on the mechanisms behind neuropathic pain, chronic... pain related to nerve injury. We are investigating biophysical models of the impact of general anesthesia on the central nervous system; informational aspects of sensory perception and the representation of sensory input; nonlinear dynamics of respiratory pattern generation; and acute perioperative pain. view more

    Research Areas: sensory perception, nerve injury, central nervous system, neuropathy, neuropathic pain, anesthesia, pain
  • Bradley Undem Lab

    Principal Investigator:
    Bradley Undem, Ph.D.
    Medicine

    Research in the Bradley Undem Lab centers around the hypothesis that the peripheral nervous sys...tem is directly involved in the processes of inflammation. This hypothesis is being studied primarily in the central airways and sympathetic ganglia. We are addressing this in a multidisciplinary fashion, using pharmacological, electrophysiological, biochemical and anatomical methodologies. view more

    Research Areas: biochemistry, electrophysiology, inflammation, pharmacology, nervous system
  • Brain Science Institute (BSi)

    Lab Website
    Principal Investigator:
    Jeffrey Rothstein, M.D., Ph.D.
    Neurology

    The Brain Science Institute (BSi) brings together both basic and clinical neuroscientists from ...across the Johns Hopkins campuses. The BSi represents one of the largest and most diverse groups in the university. The BSi's mission is to solve fundamental questions about brain development and function and to use these insights to understand the mechanisms of brain disease. This new knowledge will provide the catalyst for the facilitation and development of effective therapies. The goals of our research are to foster new programs in basic neuroscience discovery; initiate a translational research program that will develop new treatments for brain-based diseases; and encourage collaboration, interdisciplinary teams, and new thinking that will have a global influence on research and treatment of the nervous system. view more

    Research Areas: brain, neuroscience, neurology, nervous system
  • Brain Tumor Cancer Genetics Lab

    Lab Website

    The lab explores the genetic underpinnings that drive the pathogenesis of a variety of primary ...central nervous system neoplasms. We are interested in exploiting genetic changes for both diagnostic and therapeutic purposes. Our lab is currently working on understanding the extreme responders and extreme clinical phenotypes of brain and spinal cord tumors to identify factors that may modulate responses to therapy. view more

    Research Areas: brain tumor genetics, brain tumor
  • Center for Nanomedicine

    Lab Website
    Principal Investigator:
    Justin Hanes, Ph.D.
    Ophthalmology

    The Center for Nanomedicine engineers drug and gene delivery technologies that have significant... implications for the prevention, treatment and cure of many major diseases facing the world today. Specifically, we are focusing on the eye, central nervous system, respiratory system, women's health, gastrointestinal system, cancer, and inflammation.

    We are a unique translational nanotechnology effort located that brings together engineers, scientists and clinicians working under one roof on translation of novel drug and gene delivery technologies
    view more

    Research Areas: central nervous system, respiratory system, nanotechnology, cancer, drugs, women's health, inflammation, eye, gastrointestinal
  • Dwight Bergles Laboratory

    Lab Website
    Principal Investigator:
    Dwight Bergles, Ph.D.
    Neuroscience

    The Bergles Laboratory studies synaptic physiology, with an emphasis on glutamate transporters ...and glial involvement in neuronal signaling. We are interested in understanding the mechanisms by which neurons and glial cells interact to support normal communication in the nervous system. The lab studies glutamate transport physiology and function. Because glutamate transporters play a critical role in glutamate homeostasis, understanding the transporters' function is relevant to numerous neurological ailments, including stroke, epilepsy, and neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). Other research in the laboratory focuses on signaling between neurons and glial cells at synapses. Understanding how neurons and cells communicate, may lead to new approaches for stimulating re-myelination following injury or disease. Additional research in the lab examines how a unique form of glia-to-neuron signaling in the cochlea influences auditory system development, whether defects in cell communication lead to certain hereditary forms of hearing impairment, and if similar mechanisms are related to sound-induced tinnitus. view more

    Research Areas: epilepsy, synaptic physiology, ALS, stroke, neuronal signaling, glutamate transport physiology and function, audiology, neuroscience, neurology, nervous system, molecular biology
  • Elizabeth Tucker Lab

    Lab Website

    Research in the Elizabeth Tucker Lab aims to find treatments that decrease neuroinflammation an...d improve recovery, as well as to improve morbidity and mortality in patients with infectious neurological diseases. We are currently working with Drs. Sujatha Kannan and Sanjay Jain to study neuroinflammation related to central nervous system tuberculosis – using an animal model to examine the role of neuroinflammation in this disease and how it can differ in developing brains and adult brains. Our team also is working with Dr. Jain to study noninvasive imaging techniques for use in monitoring disease progression and evaluating treatment responses. view more

    Research Areas: infectious disease, imaging, neuroinflammation, morbidity, tuberculosis
  • Haughey Lab: Neurodegenerative and Neuroinfectious Disease

    Lab Website
    Principal Investigator:
    Norman Haughey, Ph.D.
    Neurology
    Neurosurgery

    Dr. Haughey directs a disease-oriented research program that address questions in basic neurobi...ology, and clinical neurology. The primary research interests of the laboratory are:

    1. To identify biomarkers markers for neurodegenerative diseases including HIV-Associated Neurocognitive Disorders, Multiple Sclerosis, and Alzheimer’s disease. In these studies, blood and cerebral spinal fluid samples obtained from ongoing clinical studies are analyzed for metabolic profiles through a variety of biochemical, mass spectrometry and bioinformatic techniques. These biomarkers can then be used in the diagnosis of disease, as prognostic indicators to predict disease trajectory, or as surrogate markers to track the effectiveness of disease modifying interventions.
    2. To better understand how the lipid components of neuronal, and glial membranes interact with proteins to regulate signal transduction associated with differentiation, motility, inflammatory signaling, survival, and neuronal excitability.
    3. To understand how extracellular vesicles (exosomes) released from brain resident cells regulate neuronal excitability, neural network activity, and peripheral immune responses to central nervous system damage and infections.
    4. To develop small molecule therapeutics that regulate lipid metabolism as a neuroprotective and restorative strategy for neurodegenerative conditions.
    view more

    Research Areas: multiple sclerosis, PTSD, HAND, HIV
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