Skip Navigation

Find a Research Lab

Research Lab Results for nerve regeneration

Displaying 1 to 2 of 2 results
Results per page:
  • Merkin Peripheral Neuropathy and Nerve Regeneration Center

    Lab Website

    The Merkin Center's goal is to advance peripheral neuropathy research, deepen our understanding... of these conditions and their causes and develop viable therapies. The center will tackle pressing research questions in peripheral neuropathy, with a particular focus on areas that impede the development of better diagnostic and therapeutic strategies.

    view more

    Research Areas: nerve regeneration, peripheral neuropathy
  • Mohamed Farah Lab

    Lab Website
    Principal Investigator:
    Mohamed Farah, Ph.D.

    The Mohamed Farah Lab studies axonal regeneration in the peripheral nervous system. We've found... that genetic deletion and pharmacological inhibition of beta-amyloid cleaving enzyme (BACE1) markedly accelerate axonal regeneration in the injured peripheral nerves of mice. We postulate that accelerated nerve regeneration is due to blockade of BACE1 cleavage of two different BACE1 substrates. The two candidate substrates are the amyloid precursor protein (APP) in axons and tumor necrosis factor receptor 1 (TNFR1) on macrophages, which infiltrate injured nerves and clear the inhibitory myelin debris. In the coming years, we will systematically explore genetic manipulations of these two substrates in regard to accelerated axonal regeneration and rapid myelin debris removal seen in BACE1 KO mice. We also study axonal sprouting and regeneration in motor neuron disease models. view more

    Research Areas: genomics, nerve regeneration, nervous system
  1. 1
Create lab profile
Edit lab profile
back to top button