The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned an...d characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.

Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S. view more