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• Gregg Semenza Lab

  The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned and characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.
  
  Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S.

  Research Areas: cancer, oxygen, lung disease, genomics, HIF-1, pathogenesis, myocardial ischemia

  

  Principal Investigator

  Gregg Semenza, M.D., Ph.D.

  Department

  Pediatrics
  

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