Find a Research Lab

Enter a research interest, principal investigator or keyword

Displaying 1 to 3 of 3 results for metabolomics

Show: 10 · 20 · 50

  1. 1
  • Le Cancer Metabolism Research Lab

    Dr. Anne Le's research primarily focuses on cancer metabolism and metabolic aspects of other diseases. Using metabolomics technologies, her work has led to breakthrough discoveries revealing several characteristic features of the metabolism of cancer. One of these, the dependence of cancer cells on glutamine metabolism, has translated into clinical trials as a novel therapy for cancer patients. Furthermore, her lab tracked the metabolic pathways in the remaining tumor cells after this novel therapy and identified the best-suited drugs for combined synergistic therapy. The depth of Dr. Le's expertise in cancer metabolism, in collaboration with other experts at Johns Hopkins, will lead to improved outcomes for cancer therapy.

    Research Areas: cancer, metabolomics technologies, cancer metabolism

    Lab Website

    Principal Investigator

    Anne Le, H.D.R., M.D., M.S.

    Department

    Oncology
    Pathology

  • Namandje N. Bumpus Lab

    The Bumpus Laboratory uses mass spectrometry and molecular pharmacology-based approaches to study the biotransformation of clinically used drugs by the cytochromes P450s. Specifically, we are studying ways to define a role for cytochrome P450-dependent metabolites in the drug-induced acute liver failure that is associated with certain antiviral drugs used to treat HIV and hepatitis C. Our long-term goal is to gain information that can be used to develop therapies that are devoid of toxic events by preventing the formation of a toxic metabolite or by developing strategies for preventing toxicity using concomitant therapy.

    Research Areas: antiviral therapy, drug metabolism, mass spectrometry, HIV, drugs, cellular signaling, cytochromes P450, pharmacology, molecular pharmacology, hepatitis C, metabolomics

    Lab Website

    Principal Investigator

    Namandje Bumpus, Ph.D.

    Department

    Medicine

  • Saraswati Sukumar Lab

    Our lab is focused on using comprehensive gene expression, methylation and sequencing and metabolomics analysis to identify alterations in breast cancer, and exploiting these for early detection and therapy. Among deferentially expressed genes, our lab has focused on the HOX genes. HOX genes are intimately involved in the development of resistance to both chemotherapy and to agents targeting the estrogen receptor. Our work explores the alternate pathways that are activated by HOX proteins leading to this resistance and novel treatments to overcome resistance in both tissue culture and xenograft models. In addition, epigenetically silenced genes and a metabolic reprogramming in tumors also trigger novel early detection and therapeutic strategies. We are testing the utility of differentiation therapy through reactivating RAR-beta in breast cancer using histone deacetylase inhibitors with great success. Also, we are targeting enzymes involved in gluconeogenesis and glycolysis with small ...molecule FDA-approved antimetabolites to achieve antitumor effects. view more

    Research Areas: breast cancer, genetics

    Lab Website

    Principal Investigator

    Saraswati Sukumar, Ph.D.

    Department

    Oncology

  1. 1