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Research Lab Results for lung injury

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  • Brian Garibaldi Lab

    Principal Investigator:
    Brian Garibaldi, M.D.
    Medicine

    Research in the Brian Garibaldi Lab focuses on acute lung injury (ALI) resolution. Recently, we... evaluated the mechanisms underlying mobility therapy and found that therapeutic exercise reduces neutrophilic lung injury and skeletal muscle wasting in ALI mice. view more

    Research Areas: pulmonary medicine, acute lung injury
  • Cardiac Surgery Research Lab

    Lab Website
    Principal Investigator:
    Jennifer Lawton, M.D.
    Medicine
    Surgery

    Founded in 1942 by surgeon Alfred Blalock and surgical technician Vivien Thomas, the Cardiac Su...rgery Research Lab at The Johns Hopkins Hospital serves not only to spearhead discovery and innovation in cardiothoracic surgery, but also to train future leaders in the field. Active areas of investigation include the development of novel, nanoparticle-based therapeutics to mitigate acute lung injury, avoid neurological injury during cardiac surgery, and improve organ preservation during heart and lung transplantation. The lab is also active in a variety of clinical research projects aimed at improving outcomes for our patients.

    Equally important, the lab plays a critical role in training residents for impactful careers in academic cardiothoracic surgery. Medical students, residents, and fellows receive hands-on simulation experiences to hone surgical skills outside of the operating room. The lab also serves as a training ground to develop research and investigation skills as trainees learn methods of advanced statistical analysis and academic writing. Special programs for undergraduates and medical students help develop their passion for cardiac surgery and surgical research, giving unique opportunities to young talent.
    view more

    Research Areas: cardiac surgery, nanotechnology, cardiothoracic surgery, surgical models, heart transplant, lung transplant
  • David Hager Lab

    Principal Investigator:
    David Hager, M.D., Ph.D.
    Medicine

    Research in the David Hager Lab focuses on critical care medicine. Recent studies includes an a...nalysis of advances in the management of the acute respiratory distress syndrome (ARDS) and the development of a targeted real-time early warning score predicting septic shock. Other interests include ventilator-induced lung injury and high-frequency ventilation. view more

    Research Areas: critical care medicine, acute respiratory distress syndrome, high-frequency ventilation, ventilator-induced lung injury
  • Franco D’Alessio Lab

    Principal Investigator:
    Franco D'Alessio, M.D.
    Medicine

    The Franco D’Alessio Lab investigates key topics within the fields of critical care, internal a...nd pulmonary medicine. We primarily explore immunological determinants of acute lung inflammation and repair. Our lab also investigates age-dependent lung immune response in patients with acute lung injury and acute respiratory distress syndrome (ARDS), regulatory T-cells in lung injury and repair, and modulation of alveolar macrophage innate immune response in ARDS. view more

    Research Areas: critical care medicine, acute respiratory distress syndrome, acute lung injury, lung inflammation, lung disease, T cells
  • Larissa Shimoda Lab

    Principal Investigator:
    Larissa Shimoda, Ph.D., M.S.
    Medicine

    Research in the Larissa Shimoda Lab focuses on several important topics within pulmonary and cr...itical care medicine. We primarily study pulmonary arterial responses to chronic hypoxia as well as hypoxic pulmonary vasoconstriction and oxidant-mediated lung injury. Our recent research has included investigating the effects of chronic hypoxia on pulmonary circulation and the ways in which hypoxia-inducible factors impact pulmonary vascular responses to hypoxia. We have also studied vascular remodeling in patients with pulmonary hypertension. view more

    Research Areas: critical care medicine, lung injury, pulmonary medicine, lung disease, hypoxia
  • Li Gao Lab

    Principal Investigator:
    Li Gao, M.D., Ph.D.
    Medicine

    The Li Gao Lab researches functional genomics, molecular genetics and epigenetics of complex ca...rdiopulmonary and allergic diseases, with a focus on translational research applying fundamental genetic insight into the clinical setting. Current research includes implementation of high-throughput technologies in the fields of genome-wide association studies (GWAS), massively parallel sequencing, gene expression analysis, epigenetic mapping and integrative genomics in ongoing research of complex lung diseases and allergic diseases including asthma, atopic dermatitis (AD), pulmonary arterial hypertension, COPD, sepsis and acute lung injury/ARDS; and epigenetic contributions to pulmonary arterial hypertension associated with systemic sclerosis. view more

    Research Areas: pulmonary arterial hypertension, molecular genetics, cardiopulmonary diseases, asthma, epigenetics, complex lung disease, allergies, genomics, COPD, atopic dermatitis
  • Mahendra Damarla Lab

    Principal Investigator:
    Mahendra Damarla, M.D.
    Medicine

    Work in the Mahendra Damarla Lab focuses primarily on the field of vascular biology. Much of ou...r research involves exploring alternatives to mechanical ventilation as a therapy for acute lung injury. We investigate mitogen-activated protein kinase-activated protein kinase 2 as a method to mediate apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. We have also conducted research on the prevalence of confirmatory tests in patients hospitalized with congestive heart failure or chronic obstructive pulmonary disease (COPD). view more

    Research Areas: critical care medicine, acute lung injury, lung disease, COPD, vascular biology, hypoxia
  • Outcomes After Critical Illness and Surgery Group

    Lab Website
    Principal Investigator:
    Dale Needham, M.D., Ph.D.
    Medicine

    The Outcomes After Critical Illness and Surgery Group is focused on understanding and improving... patient outcomes after critical illness and surgery. Research projects include improving long-term outcomes research for acute respiratory distress syndrome/acute respiratory failure (ARDS/ARF) patients; examining the long-term outcomes for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) patients; and evaluating the effects of lower tidal volume ventilation and other aspects of critical illness and ICU care on the long-term physical and mental health outcomes of ALI/ARDS patients. view more

    Research Areas: critical care medicine, acute respiratory distress syndrome, pulmonary medicine, acute lung injury, rehabilitation
  • Pedro Alejandro Mendez-Tellez Lab

    Work in the Pedro Alejandro Mendez-Tellez Lab focuses on critical care medicine and acute lung ...injury. Recent studies include evaluating demographic and clinical factors associated with self-reported dysphagia after oral endotracheal intubation and mechanical ventilation in patients with acute lung injury. We've also analyzed orticosteroids and their relationship with delirium in critically ill patients. view more

    Research Areas: critical care medicine, lung injury, ICU
  • Rachel Damico Lab

    Principal Investigator:
    Rachel Damico, M.D., Ph.D.
    Medicine

    Work in the Rachel Damico Lab explores topics within the fields of vascular biology and pulmona...ry medicine, with a focus on acute lung injury and apoptosis in lung diseases. Our studies have included examining idiopathic and scleroderma-associated pulmonary arterial hypertension, vascular receptor autoantibodies, and the link between inflammation and the Warburg phenomenon in patients with pulmonary arterial hypertension. We have also researched the inhibitory factor of macrophage migration and its governing of endothelial cell sensitivity to LPS-induced apoptosis. view more

    Research Areas: critical care medicine, acute lung injury, lung disease, vascular biology, apoptosis
  • Vsevolod Polotsky Lab

    Principal Investigator:
    Vsevolod Polotsky, M.D., Ph.D.
    Medicine

    The Vsevolod Polotsky Lab conducts research on pulmonary diseases, including hypoxia and sleep ...apnea, with a focus on their relation to obesity and metabolic syndrome. Our studies have explored topics such as the effects of age, leptin and obesity on the upper airway; the relationship between obstructive sleep apnea, insulin resistance and steatohepatitis in severely obese patients; and the impact of intermittent hypoxia on diet-induced obesity. We also have a long-standing interest in critical care pulmonary medicine and have conducted research on various aspects of murine lung injury. view more

    Research Areas: critical care medicine, obesity, pulmonary medicine, obstructive sleep apnea, lung disease, metabolic syndrome, hypoxia
  • William Checkley Lab

    Lab Website
    Principal Investigator:
    William Checkley, M.D., Ph.D.
    Medicine

    Research in the William Checkley Lab explores the field of lung health, with an emphasis on the... epidemiology of obstructive lung diseases as well as acute lung injury and mechanical ventilation. We also explore the interactions between nutrition and infection, and the impact of environmental exposures to health. view more

    Research Areas: critical care medicine, epidemiology, international lung health, mechanical ventilation, acute lung injury, lung disease
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