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Displaying 1 to 21 of 21 results for lung disease

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  • Antoine Azar Lab

    The Antoine Azar Lab conducts research on topics related to primary immunodeficiency diseases, allergies and lung disease. Specifically, we explore the role of primary immunodeficiency in certain difficult-to-treat chronic lung diseases, such as COPD, emphysema and asthma.

    Research Areas: emphysema, immunology, asthma, allergies, lung disease, COPD

    Principal Investigator

    Antoine Azar, M.D.

    Department

    Medicine

  • Christian Merlo Lab

    Work in the Christian Merlo Lab includes studies on pulmonary arteriovenous malformations, outcomes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. Our recent research has also explored recipient and donor variables in the success or failure of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients.

    Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant

    Principal Investigator

    Christian Merlo, M.D., M.P.H.

    Department

    Medicine

  • Franco D’Alessio Lab

    The Franco D’Alessio Lab investigates key topics within the fields of critical care, internal and pulmonary medicine. We primarily explore immunological determinants of acute lung inflammation and repair. Our lab also investigates age-dependent lung immune response in patients with acute lung injury and acute respiratory distress syndrome (ARDS), regulatory T-cells in lung injury and repair, and modulation of alveolar macrophage innate immune response in ARDS.

    Research Areas: critical care medicine, acute respiratory distress syndrome, acute lung injury, lung inflammation, lung disease, T cells

    Principal Investigator

    Franco D'Alessio, M.D.

    Department

    Medicine

  • Gregg Semenza Lab

    The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned and characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.

    Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S.

    Research Areas: cancer, oxygen, lung disease, genomics, HIF-1, pathogenesis, myocardial ischemia

    Principal Investigator

    Gregg Semenza, M.D., Ph.D.

    Department

    Pediatrics

  • Gregory Diette Laboratory

    The Gregory Diette Laboratory studies the epidemiology of lung diseases. Our focus is on asthma, chronic obstructive pulmonary disease (COPD) and environmental causes of lung disease, including allergens and particulate matter.

    Research Areas: epidemiology, asthma, allergies, lung disease, COPD

    Principal Investigator

    Gregory Diette, M.D.

    Department

    Medicine

  • Kelly E. Dooley Laboratory

    Research focuses on clinical pharmacology of new anti-tuberculosis regimens with an emphasis on: (1) Phase I clinical trials of new or existing anti-TB drugs including dose escalation trials and studies of drug-drug interactions between anti-TB agents and antiretrovirals to treat HIV; (2) Use of PK/PD analysis and modelling in Phase II tuberculosis clinical treatment trials to determine concentration-effect relationships that will allow for optimization of dosing; and (3) Evaluation of TB and HIV drug concentrations in special populations, such as pregnant women and children; (4) Evaluation of treatment-shortening regimens for drug-sensitive TB and investigational regimens for treatment of multidrug-resistant TB; and (5) Translational work involving novel animal models of cavitary pulmonary TB disease to understand drug distribution in diseased lung.

    Research Areas: anti-infective drugs, antiretroviral therapies, tuberculosis and HIV treatments, HIV, lung disease, pharmacology, tuberculosis

    Lab Website

    Principal Investigator

    Kelly Dooley, M.D., M.P.H., Ph.D.

    Department

    Medicine

  • Larissa Shimoda Lab

    Research in the Larissa Shimoda Lab focuses on several important topics within pulmonary and critical care medicine. We primarily study pulmonary arterial responses to chronic hypoxia as well as hypoxic pulmonary vasoconstriction and oxidant-mediated lung injury. Our recent research has included investigating the effects of chronic hypoxia on pulmonary circulation and the ways in which hypoxia-inducible factors impact pulmonary vascular responses to hypoxia. We have also studied vascular remodeling in patients with pulmonary hypertension.

    Research Areas: critical care medicine, lung injury, pulmonary medicine, lung disease, hypoxia

    Principal Investigator

    Larissa Shimoda, M.S., Ph.D.

    Department

    Medicine

  • Li Gao Lab

    The Li Gao Lab researches functional genomics, molecular genetics and epigenetics of complex cardiopulmonary and allergic diseases, with a focus on translational research applying fundamental genetic insight into the clinical setting. Current research includes implementation of high-throughput technologies in the fields of genome-wide association studies (GWAS), massively parallel sequencing, gene expression analysis, epigenetic mapping and integrative genomics in ongoing research of complex lung diseases and allergic diseases including asthma, atopic dermatitis (AD), pulmonary arterial hypertension, COPD, sepsis and acute lung injury/ARDS; and epigenetic contributions to pulmonary arterial hypertension associated with systemic sclerosis.

    Research Areas: pulmonary arterial hypertension, molecular genetics, cardiopulmonary diseases, asthma, epigenetics, complex lung disease, allergies, genomics, COPD, atopic dermatitis

    Principal Investigator

    Li Gao, M.D., Ph.D.

    Department

    Medicine

  • Mahendra Damarla Lab

    Work in the Mahendra Damarla Lab focuses primarily on the field of vascular biology. Much of our research involves exploring alternatives to mechanical ventilation as a therapy for acute lung injury. We investigate mitogen-activated protein kinase-activated protein kinase 2 as a method to mediate apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. We have also conducted research on the prevalence of confirmatory tests in patients hospitalized with congestive heart failure or chronic obstructive pulmonary disease (COPD).

    Research Areas: critical care medicine, acute lung injury, lung disease, COPD, vascular biology, hypoxia

    Principal Investigator

    Mahendra Damarla, M.D.

    Department

    Medicine

  • Meredith McCormack Lab

    Research in the Meredith McCormack Lab deals primarily with pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and the role of environmental exposures in lung diseases. We have researched the factors that contribute to inner-city asthma, with a focus on how particulate matter air pollution impacts pulmonary function. We are also part of the LIBERATE clinical study, which is focused on patients who experience difficulty breathing and have been diagnosed with severe emphysema. We also have a longstanding interest in the effects of race/ethnicity, poverty and urbanization on nutrition and food allergies.

    Research Areas: emphysema, environmental exposure, asthma, lung disease, COPD, health disparities

    Principal Investigator

    Meredith McCormack, M.D., M.H.S.

    Department

    Medicine

  • Mitzner Laboratory

    The Mitzner Laboratory studies the physiologic and pathologic basis of lung health and diseases such as emphysema and asthma. We are currently researching why chronic changes in the lung remain for long periods after initial insults have disappeared. Using phenotyping in whole animal models alongside the assessment of the immunologic status of cells and interactive signaling, we examine lung-tissue damage that creates a chronic immunologic response.

    Research Areas: emphysema, phenotyping, asthma, lung disease

  • Nadia Hansel Lab

    Research in the Nadia Hansel Lab investigates the clinical, pathophysiologic and public health aspects of pulmonary diseases, with a focus on asthma and chronic obstructive pulmonary disease (COPD). We have explored how environmental exposures, nutrition and diet, comorbidity and other factors influence the outcomes of diseases such as asthma and COPD.

    Research Areas: airway diseases, immunology, asthma, allergies, lung disease, COPD

    Principal Investigator

    Nadia Hansel, M.D., M.P.H.

    Department

    Medicine

  • Paul M. Hassoun Lab

    The Paul M. Hassoun Lab leads research on the source and treatment of pulmonary arterial hypertension in scleroderma.

    Research Areas: pulmonary arterial hypertension, scleroderma, hypertension, lung disease

    Principal Investigator

    Paul Hassoun, M.D.

    Department

    Medicine

  • Rachel Damico Lab

    Work in the Rachel Damico Lab explores topics within the fields of vascular biology and pulmonary medicine, with a focus on acute lung injury and apoptosis in lung diseases. Our studies have included examining idiopathic and scleroderma-associated pulmonary arterial hypertension, vascular receptor autoantibodies, and the link between inflammation and the Warburg phenomenon in patients with pulmonary arterial hypertension. We have also researched the inhibitory factor of macrophage migration and its governing of endothelial cell sensitivity to LPS-induced apoptosis.

    Research Areas: critical care medicine, acute lung injury, lung disease, vascular biology, apoptosis

    Principal Investigator

    Rachel Damico, M.D., Ph.D.

    Department

    Medicine

  • Robert Fitzgerald Laboratory

    The Robert Fitzgerald Laboratory studies cardiopulmonary physiology, especially cardiopulmonary control. We have focused in particular on the operation of the carotid body and the role of acetylcholine in its functioning. We have also examined the reflex effects of carotid body stimulation in various organs as well as the reflex response of ACTH and adrenal cortical hormones to hypoxic peripheral arterial chemoreceptor stimulation. We are currently interested in the spleen, as it is the only organ other than the lung that demonstrates increased vascular resistance in response to local hypoxia.

    Research Areas: acetylcholine, carotid body, cardiopulmonary diseases, lung disease, hypoxia

    Principal Investigator

    Robert Fitzgerald, Ph.D.

    Department

    Medicine

  • Robert H. Brown Lab

    Work in the Robert H. Brown Lab explores several topics within pulmonary physiology, with a long-term goal of understanding the structural changes in the lungs that lead to the pathophysiology of lung disease. Our core studies examine the structure-function relationship of pulmonary airways and vessels as well as their role in chronic obstructive pulmonary disease (COPD) and reactive airway disease. Recent research has involved studying the mechanisms and treatment of COPD progression, new methods for treating asthma, and lung inflation and airway hyperresponsiveness. We are also exploring the impact of HIV infection on the etiology of lung disease and the pathophysiologic consequences of lung distention.

    Research Areas: asthma, HIV, pulmonary physiology, lung disease, COPD, reactive airway disease

  • Robert Wise Lab

    The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD). We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma.

    Research Areas: critical care medicine, emphysema, scleroderma, pulmonary medicine, asthma, lung-volume reduction surgery, COPD

    Principal Investigator

    Robert Wise, M.D.

    Department

    Medicine

  • Sanjay Desai Lab

    Research in the Sanjay Desai Lab focuses primarily on clinical outcomes in survivors of critical illnesses, such as acute lung injury. We also investigate techniques to improve graduate medical education and are conducting a clinical trial on the comparative effectiveness of models that optimize patient safety and resident education. Our research examines factors such as residency work-hour reform, hand hygiene practices and the use of etiquette-based communication.

    Research Areas: medical education, critical care medicine, lung disease

    Principal Investigator

    Sanjay Desai, M.D.

    Department

    Medicine

  • Sonye Danoff Lab

    Research in the Sonye Danoff Lab includes both basic and translational studies of lung fibrosis. We have explored topics such as the role of support measures and palliative care, pulmonary manifestations of Sjogren's syndrome, idiopathic inflammatory myopathies and the treatment of cough in idiopathic pulmonary fibrosis. Our research has also involved investigating the lung as a potential target for the immune reaction in myositis.

    Research Areas: myositis, interstitial lung diseases, Sjogren's syndrome, lung disease, pulmonary fibrosis, autoimmune diseases

    Principal Investigator

    Sonye Danoff, M.D., Ph.D.

    Department

    Medicine

  • Vsevolod Polotsky Lab

    The Vsevolod Polotsky Lab conducts research on pulmonary diseases, including hypoxia and sleep apnea, with a focus on their relation to obesity and metabolic syndrome. Our studies have explored topics such as the effects of age, leptin and obesity on the upper airway; the relationship between obstructive sleep apnea, insulin resistance and steatohepatitis in severely obese patients; and the impact of intermittent hypoxia on diet-induced obesity. We also have a long-standing interest in critical care pulmonary medicine and have conducted research on various aspects of murine lung injury.

    Research Areas: critical care medicine, obesity, pulmonary medicine, obstructive sleep apnea, lung disease, metabolic syndrome, hypoxia

    Principal Investigator

    Vsevolod Polotsky, M.D., Ph.D.

    Department

    Medicine

  • William Checkley Lab

    Research in the William Checkley Lab explores the field of lung health, with an emphasis on the epidemiology of obstructive lung diseases as well as acute lung injury and mechanical ventilation. We also explore the interactions between nutrition and infection, and the impact of environmental exposures to health.

    Research Areas: critical care medicine, epidemiology, international lung health, mechanical ventilation, acute lung injury, lung disease

    Lab Website

    Principal Investigator

    William Checkley, M.D., Ph.D.

    Department

    Medicine

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