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Displaying 1 to 10 of 10 results for insulin

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  • Fu Lab

    The Fu Lab is a basic research lab that studies zinc transport, with a particular focus on which step in the zinc transport process may be modulated and how. Dr. Fu's lab uses parallel cell biology and proteomic approaches to understand how these physiochemical principles are applied to mammalian zinc transporters and integrated to the physiology of pancreatic beta cells. This research has implications for understanding how zinc transport is related to diabetes and insulin intake.

    Research Areas: cell biology, proteomics, zinc, pancreatic cells, diabetes

    Lab Website

    Principal Investigator

    Dax Fu, Ph.D.

    Department

    Physiology

  • Guang William Wong Lab

    The Wong Lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis. We are currently addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. We use transgenic and knockout mouse models, as well as cell culture systems, to address the role of the CTRP family of hormones in physiological and disease states. We also aim to identify the receptors that mediate the biological functions of CTRPs.

    Research Areas: energy metabolism, insulin resistance, hormones, diabetes, metabolic homeostasis

    Principal Investigator

    Guang Wong, Ph.D.

    Department

    Physiology

  • Jonathan Jun Lab

    The Jonathan Jun Lab studies the function of lipolysis in intermittent hypoxia-induced insulin resistance.

    Research Areas: critical care medicine, lipolysis, pulmonary medicine, intermittent hypoxia-induced insulin resistance

    Lab Website

    Principal Investigator

    Jonathan Jun, M.D.

    Department

    Medicine

  • Naresh Punjabi Lab

    The Naresh Punjabi Lab primarily studies sleep apnea, epidemiology, cardiovascular disease, insulin resistance and type 2 diabetes. Our current research focuses on the epidemiology of sleep apnea with a particular emphasis on associated sequelae, including insulin resistance, type 2 diabetes mellitus and cardiovascular disease. We have been part of the multi-center Sleep Heart Health Study, an epidemiological study on the longitudinal effects of sleep apnea on hypertension, cardiovascular disease and mortality. Our lab is examining the independent effects of intermittent hypoxia on various pathways to help elucidate the links between sleep apnea, insulin resistance and metabolic dysfunction.

    Research Areas: epidemiology, type 2 diabetes, insulin resistance, cardiovascular diseases, sleep apnea

    Principal Investigator

    Naresh Punjabi, M.D., Ph.D.

    Department

    Medicine

  • Rita Kalyani Lab

    Research in the Rita Kalyani Lab examines the decreased physical functioning observed in patients with diabetes as they age. Through several ongoing epidemiological cohorts, we are investigating the association of high blood glucose and high insulin levels with accelerated muscle loss, and possible contributions to the physical disability observed in diabetes. We are currently involved in clinical studies that aim to understand the underlying mechanisms for these associations and to facilitate the development of novel strategies to prevent muscle loss and disability in people with diabetes.

    Research Areas: metabolism, insulin, diabetes, cardiovascular diseases, endocrinology, blood glucose

    Principal Investigator

    Rita Kalyani, M.D., M.H.S.

    Department

    Medicine

  • Sheng Wu Laboratory

    The Sheng Wu Laboratory studies the insulin/androgen receptor (AR) actions on the developmental and regulation of the reproductive and metabolic functions. We use multiple animal models (obesity, androgen implantation, and conditional knockout) to investigate the pathophysiology of polycystic ovarian syndrome (PCOS) and the developmental factors and their target tissues that contribute to PCOS manifestation.

    Research Areas: reproduction, insulin, polycystic ovarian syndrome, endocrinology, androgen receptor

    Principal Investigator

    Sheng Wu, M.Sc., Ph.D.

    Department

    Pediatrics

  • Thomas W. Donner Lab

    The Thomas W. Donner Lab focuses on type 1 and type 2 diabetes, with an emphasis on the prevention of complications in patients with these conditions. We’re currently collaborating with Dr. Abdel Hamad to inhibit B-regulatory cell apoptosis through a novel monoclonal antibody that targets the probable apoptotic factor. We also lead a multi-center, international consortium of researchers studying ways to prevent type 1 diabetes and preserve insulin secretion in people who have been recently diagnosed with the chronic condition.

    Research Areas: cell apoptosis, insulin, diabetes

    Principal Investigator

    Thomas Donner, M.D.

    Department

    Medicine

  • Todd Brown Lab

    The Todd Brown Lab focuses on metabolic, endocrine and skeletal abnormalities in HIV-infected patients, particularly as these factors relate to aging. Our studies take an epidemiologic approach to understanding the occurrence and prevalence of insulin resistance, diabetes, and anthropometric changes in HIV patients and their relationship to antiretroviral treatment.

    Research Areas: antiretroviral therapies, insulin resistance, metabolism, HIV, diabetes, endocrinology, skeletal abnormalities

    Principal Investigator

    Todd Brown, M.D., Ph.D.

    Department

    Medicine

  • Vsevolod Polotsky Lab

    The Vsevolod Polotsky Lab conducts research on pulmonary diseases, including hypoxia and sleep apnea, with a focus on their relation to obesity and metabolic syndrome. Our studies have explored topics such as the effects of age, leptin and obesity on the upper airway; the relationship between obstructive sleep apnea, insulin resistance and steatohepatitis in severely obese patients; and the impact of intermittent hypoxia on diet-induced obesity. We also have a long-standing interest in critical care pulmonary medicine and have conducted research on various aspects of murine lung injury.

    Research Areas: critical care medicine, obesity, pulmonary medicine, obstructive sleep apnea, lung disease, metabolic syndrome, hypoxia

    Principal Investigator

    Vsevolod Polotsky, M.D., Ph.D.

    Department

    Medicine

  • William B. Guggino Lab

    Work in the William B. Guggino Lab focuses on the structure of the cystic fibrosis transmembrane conductance regulator (CFTR) and water channels; the molecular structure of transport proteins in epithelial cell membranes; and gene therapies to treat cystic fibrosis (CF) patients. We are also working to identify CF’s specific defect in chloride channel regulation. One recent study showed that insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR.

    Research Areas: cell biology, cystic fibrosis, kidney diseases, gene therapy, ion channels

    Lab Website

    Principal Investigator

    William Guggino, Ph.D.

    Department

    Physiology

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