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The Wong Lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis. We are currently addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. We use transgenic and knockout mouse models, as well as cell culture systems, to address the role of the CTRP family of hormones in physiological and disease states. We also aim to identify the receptors that mediate the biological functions of CTRPs.
The Jonathan Jun Lab studies the function of lipolysis in intermittent hypoxia-induced insulin resistance.
The Naresh Punjabi Lab primarily studies sleep apnea, epidemiology, cardiovascular disease, insulin resistance and type 2 diabetes. Our current research focuses on the epidemiology of sleep apnea with a particular emphasis on associated sequelae, including insulin resistance, type 2 diabetes mellitus and cardiovascular disease. We have been part of the multi-center Sleep Heart Health Study, an epidemiological study on the longitudinal effects of sleep apnea on hypertension, cardiovascular disease and mortality. Our lab is examining the independent effects of intermittent hypoxia on various pathways to help elucidate the links between sleep apnea, insulin resistance and metabolic dysfunction.
The Todd Brown Lab focuses on metabolic, endocrine and skeletal abnormalities in HIV-infected patients, particularly as these factors relate to aging. Our studies take an epidemiologic approach to understanding the occurrence and prevalence of insulin resistance, diabetes, and anthropometric changes in HIV patients and their relationship to antiretroviral treatment.
The Vsevolod Polotsky Lab conducts research on pulmonary diseases, including hypoxia and sleep apnea, with a focus on their relation to obesity and metabolic syndrome. Our studies have explored topics such as the effects of age, leptin and obesity on the upper airway; the relationship between obstructive sleep apnea, insulin resistance and steatohepatitis in severely obese patients; and the impact of intermittent hypoxia on diet-induced obesity. We also have a long-standing interest in critical care pulmonary medicine and have conducted research on various aspects of murine lung injury.
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