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• Guang William Wong Lab

  The Wong Lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic homeostasis. We are currently addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. We use transgenic and knockout mouse models, as well as cell culture systems, to address the role of the CTRP family of hormones in physiological and disease states. We also aim to identify the receptors that mediate the biological functions of CTRPs.

  Research Areas: energy metabolism, insulin resistance, hormones, diabetes, metabolic homeostasis

  

  Principal Investigator

  Guang Wong, Ph.D.

  Department

  Physiology
  

• Jonathan Jun Lab

  The Jonathan Jun Lab studies the function of lipolysis in intermittent hypoxia-induced insulin resistance.

  Research Areas: critical care medicine, lipolysis, pulmonary medicine, intermittent hypoxia-induced insulin resistance

  Lab Website

  

  Principal Investigator

  Jonathan Jun, M.D.

  Department

  Medicine
  

• Naresh Punjabi Lab

  The Naresh Punjabi Lab primarily studies sleep apnea, epidemiology, cardiovascular disease, insulin resistance and type 2 diabetes. Our current research focuses on the epidemiology of sleep apnea with a particular emphasis on associated sequelae, including insulin resistance, type 2 diabetes mellitus and cardiovascular disease. We have been part of the multi-center Sleep Heart Health Study, an epidemiological study on the longitudinal effects of sleep apnea on hypertension, cardiovascular disease and mortality. Our lab is examining the independent effects of intermittent hypoxia on various pathways to help elucidate the links between sleep apnea, insulin resistance and metabolic dysfunction.

  Research Areas: epidemiology, type 2 diabetes, insulin resistance, cardiovascular diseases, sleep apnea

  

  Principal Investigator

  Naresh Punjabi, M.D., Ph.D.

  Department

  Medicine
  

• Todd Brown Lab

  The Todd Brown Lab focuses on metabolic, endocrine and skeletal abnormalities in HIV-infected patients, particularly as these factors relate to aging. Our studies take an epidemiologic approach to understanding the occurrence and prevalence of insulin resistance, diabetes, and anthropometric changes in HIV patients and their relationship to antiretroviral treatment.

  Research Areas: antiretroviral therapies, insulin resistance, metabolism, HIV, diabetes, endocrinology, skeletal abnormalities

  

  Principal Investigator

  Todd Brown, M.D., Ph.D.

  Department

  Medicine
  

• Vsevolod Polotsky Lab

  The Vsevolod Polotsky Lab conducts research on pulmonary diseases, including hypoxia and sleep apnea, with a focus on their relation to obesity and metabolic syndrome. Our studies have explored topics such as the effects of age, leptin and obesity on the upper airway; the relationship between obstructive sleep apnea, insulin resistance and steatohepatitis in severely obese patients; and the impact of intermittent hypoxia on diet-induced obesity. We also have a long-standing interest in critical care pulmonary medicine and have conducted research on various aspects of murine lung injury.

  Research Areas: critical care medicine, obesity, pulmonary medicine, obstructive sleep apnea, lung disease, metabolic syndrome, hypoxia

  

  Principal Investigator

  Vsevolod Polotsky, M.D., Ph.D.

  Department

  Medicine
  

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