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Displaying 1 to 20 of 36 results for inflammation

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  • Amita Gupta Lab

    The Amita Gupta Lab focuses on drug trials to prevent and treat HIV, tuberculosis (TB) and other co-morbidities in adults, including pregnant women and children who reside in low-income settings. We also conduct cohort studies assessing HIV, inflammation and nutrition in international settings; TB in pregnancy; and risk factors for TB in India (CTRIUMPH). We collaborate with several faculty in the Center for TB Research, Division of Infectious Diseases and the School of Public Health.

    Research Areas: global health, nutrition, infectious disease, HIV, inflammation, tuberculosis

    Principal Investigator

    Amita Gupta, M.D.

    Department

    Medicine

  • Andrew Lane Lab

    The Lane laboratory is focused on understanding molecular mechanisms underlying chronic rhinosinusitis and particularly the pathogenesis of nasal polyps.  Diverse techniques in molecular biology, immunology, physiology, and engineering are utilized to study epithelial cell innate immunity, olfactory loss, the sinus microbiome, and drug delivery to the nose and sinus cavities. Ongoing work explores how epithelial cells participate in the immune response and contribute to chronic sinonasal inflammation. The lab creates and employs transgenic mouse models of chronic sinusitis to support research in this area. Collaborations are in place with the School of Public Health to explore mechanisms of anti-viral immunity in influenza and rhinovirus, and with the University of Maryland to characterize the bacterial microbiome of the nose and sinuses in health and disease.

    Research Areas: nasal polyps, olfaction, cell culture, transgenic mice, chronic rhinosinusitis, innate immunity, molecular biology

  • Ashwin Balagopal Lab

    Research in the Ashwin Balagopal Lab examines innate immunology and hepatic inflammation. Specifically, we explore microbial translocation Kupffer cells in HIV- hepatitis C virus (HCV) coinfection, while also developing in situ liver studies of HIV-HCV pathogenesis. Previous work has focused on antiretroviral therapy, interferon sensitivity and virologic setpoint in HIV/hepatitis C virus coinfected patients.

    Research Areas: antiretroviral therapies, infectious disease, AIDS, HIV, hepatitis C

    Principal Investigator

    Ashwin Balagopal, M.D.

    Department

    Medicine

  • Bradley Undem Lab

    Research in the Bradley Undem Lab centers around the hypothesis that the peripheral nervous system is directly involved in the processes of inflammation. This hypothesis is being studied primarily in the central airways and sympathetic ganglia. We are addressing this in a multidisciplinary fashion, using pharmacological, electrophysiological, biochemical and anatomical methodologies.

    Research Areas: biochemistry, electrophysiology, inflammation, pharmacology, nervous system

    Principal Investigator

    Bradley Undem, Ph.D.

    Department

    Medicine

  • Center for Infection and Inflammation Imaging Research

    In conjunction with the Molecular Imaging Center, the Center for Infection and Inflammation Imaging Research core provides state-of-the art small animal imaging equipment, including PET, SPECT, CT and US, to support the wide range of scientific projects within the diverse research community of the Johns Hopkins University and beyond. Trained technologists assist investigators in the use of these facilities.

    Research Areas: infectious disease, imaging, inflammation

    Lab Website

    Principal Investigator

    Sanjay Jain, M.B.B.S.

    Department

    Medicine

  • Center for Nanomedicine

    The Center for Nanomedicine engineers drug and gene delivery technologies that have significant implications for the prevention, treatment and cure of many major diseases facing the world today. Specifically, we are focusing on the eye, central nervous system, respiratory system, women's health, gastrointestinal system, cancer, and inflammation.

    We are a unique translational nanotechnology effort located that brings together engineers, scientists and clinicians working under one roof on translation of novel drug and gene delivery technologies

    Research Areas: central nervous system, respiratory system, nanotechnology, cancer, drugs, women's health, inflammation, eye, gastrointestinal

    Lab Website

    Principal Investigator

    Justin Hanes, Ph.D.

    Department

    Ophthalmology

  • Chirag Parikh Lab

    Dr. Parikh's research focuses on the translation and validation of novel biomarkers for the diagnosis and prognosis of acute kidney injury. Progress in kidney diseases has been hamstrung by significant heterogeneity within the current disease definitions, which are largely based on serum creatinine. Dr. Parikh's research has addressed this critical challenge by developing biomarkers of renal tubular injury, repair, and inflammation to dissect this heterogeneity. He has assembled multicenter longitudinal prospective cohorts for translational research studies across several clinical settings of acute kidney injury and chronic kidney disease for the efficient translation of novel biomarkers.

    His research is dedicated to the process of applying discoveries generated in the laboratory and in preclinical experiments, the development of clinical studies, and the design of clinical trials. Dr. Parikh's studies have refined the clinical definition in perioperative acute kidney injury and hep...atorenal syndrome, developed strategies to reduce kidney discard in deceased donor transplantation, and advanced regulatory approvals of kidney injury biomarkers. He has also developed biomarkers to identify rapid progressors of early diabetic kidney disease before derangements in serum creatinine. Dr. Parikh's research goal is to translate our understanding of pathophysiological mechanisms into clinical practice and improve the outcomes in patients with kidney disease.

    Dr. Parikh has also been the recipient of numerous honors, including the 2017 Young Investigator Award from the American Society of Nephrology.
    view more

    Research Areas: acute kidney injury, biomarkers, Kidney Transplantation, chronic kidney disease

    Lab Website

    Principal Investigator

    Chirag Parikh, M.B.B.S., Ph.D.

    Department

    Medicine

  • Clifton O. Bingham III Lab

    Research in the Clifton O. Bingham III Lab focuses on defining clinical and biochemical disease phenotypes related to therapeutic responses in rheumatoid arthritis and osteoarthritis; developing rational clinical trial designs to test new treatments; improving patient-reported outcome measures; evaluating novel imaging modalities for arthritis; and examining the role of oral health in inflammatory arthritis.

    Research Areas: biochemistry, imaging, osteoarthritis, clinical trials, inflammation, oral health, rheumatoid arthritis

    Principal Investigator

    Clifton O. Bingham, M.D.

    Department

    Medicine

  • Cynthia Sears Laboratory

    Work in the Cynthia Sears Laboratory focuses on the bacterial contributions to the development of human colon cancer and the impact of the microbiome on other cancers and the therapy of cancer. The current work involves mouse and human studies to define how enterotoxigenic Bacteroides fragilis, pks+ Escherichia coli, Fusobacterium nucleatum, biofilms and the colonic microbiota induce chronic colonic inflammation and colon cancer. Prospective human studies of the microbiome and biofilms in screening colonoscopy are in progress as are studies to determine if and how the microbiome impacts the response of individuals with cancer to immunotherapy and other cancer therapies.

    Research Areas: epidemiology, AIDS, microbiome, colon cancer, enterotoxigenic Bacteroides fragilis, chronic colonic inflammation

    Principal Investigator

    Cynthia Sears, M.D.

    Department

    Medicine

  • Devreotes Laboratory

    The Devreotes Laboratory is engaged in genetic analysis of chemotaxis in eukaryotic cells. Our long-term goal is a complete description of the network controlling chemotactic behavior. We are analyzing combinations of deficiencies to understand interactions among network components and carrying out additional genetic screens to identify new pathways involved in chemotaxis. A comprehensive understanding of this fascinating process should lead to control of pathological conditions such as inflammation and cancer metastasis.

    Research Areas: biochemistry, cell biology, chemotaxis, cancer, genomics, inflammation

    Lab Website

    Principal Investigator

    Peter Devreotes, Ph.D.

    Department

    Cell Biology

  • Edgar Miller Lab

    Research in the Edgar Miller Lab focuses on nutrition, hypertension and kidney disease. Current projects include a National Heart, Lung, and Blood Institute study on dietary carbohydrate and glycemic index effects on markers of oxidative stress, inflammation and kidney function; and a National Institute of Diabetes and Digestive and Kidney Diseases randomized controlled trial that examines the effects of omega-3 fatty acid supplementation on urine protein excretion in diabetic kidney disease.

    Research Areas: nutrition, kidney diseases, diabetes, inflammation

    Principal Investigator

    Edgar Miller, M.D., Ph.D.

    Department

    Medicine

  • Edward Chen Lab

    Research efforts in the Edward Chen Lab focus on bleomycin-induced pulmonary fibrosis and granulomatous inflammation as well as clinical and translational studies in sarcoidosis. Our studies have included topics such as the etiologies of sarcoidosis, hylleraas hydride binding energy in diatomic electron affinities, and molecular convergence of neurodevelopmental disorders. We have also investigated the use of quantitative mass spectrometric analysis to better understand the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.

    Research Areas: pulmonary medicine, sarcoidosis, granulomatous inflammation, pulmonary fibrosis

    Principal Investigator

    Edward Chen, M.D.

    Department

    Medicine

  • Florin Selaru Lab

    Research interests in the Florin Selaru Lab comprise the molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract.

    Research Areas: gastroenterology, cancer, inflammation, molecular biology

    Principal Investigator

    Florin Selaru, M.D.

    Department

    Medicine

  • Franco D’Alessio Lab

    The Franco D’Alessio Lab investigates key topics within the fields of critical care, internal and pulmonary medicine. We primarily explore immunological determinants of acute lung inflammation and repair. Our lab also investigates age-dependent lung immune response in patients with acute lung injury and acute respiratory distress syndrome (ARDS), regulatory T-cells in lung injury and repair, and modulation of alveolar macrophage innate immune response in ARDS.

    Research Areas: critical care medicine, acute respiratory distress syndrome, acute lung injury, lung inflammation, lung disease, T cells

    Principal Investigator

    Franco D'Alessio, M.D.

    Department

    Medicine

  • Healthy Brain Program

    The Brain Health Program is a multidisciplinary team of faculty from the departments of neurology, psychiatry, epidemiology, and radiology lead by Leah Rubin and Jennifer Coughlin. In the hope of revealing new directions for therapies, the group studies molecular biomarkers identified from tissue and brain imaging that are associated with memory problems related to HIV infection, aging, dementia, mental illness and traumatic brain injury. The team seeks to advance policies and practices to optimize brain health in vulnerable populations while destigmatizing these brain disorders.

    Current and future projects include research on: the roles of the stress response, glucocorticoids, and inflammation in conditions that affect memory and the related factors that make people protected or or vulnerable to memory decline; new mobile apps that use iPads to improve our detection of memory deficits; clinical trials looking at short-term effects of low dose hydrocortisone and randomized to 28 day...s of treatment; imaging brain injury and repair in NFL players to guide players and the game; and the role of inflammation in memory deterioration in healthy aging, patients with HIV, and other neurodegenerative conditions. view less

    Research Areas: HIV infection, mental illness, aging, traumatic brain injury, dementia

  • John Schroeder Lab

    The John Schroeder Lab focuses on understanding the role human basophils and mast cells play in allergic reactions, as it relates not only to their secretion of potent inflammatory mediators (e.g., histamine and leukotriene C4) but also to their production of pro-inflammatory cytokines. We have long utilized human cells rather than cell lines in order to address the parameters, signal transduction and pharmacological aspects underlying clinically relevant basophil and mast cell responses. As a result, the lab has established protocols for rapidly isolating large numbers of basophils at high purity from human blood and for growing culture-derived mast cells/basophils from human progenitor cells. A variety of assays and techniques are also in place for concurrently detecting cytokines and mediators following a wide range of stimuli. These have facilitated the in vitro testing of numerous anti-allergic drugs for inhibitory activity on basophil and mast cell activation. The lab also studie...s counter-regulation between the IgE and innate immune receptors on human immature dendritic cell subtypes. view more

    Research Areas: cell biology, allergies, inflammation

    Principal Investigator

    John Schroeder, Ph.D.

    Department

    Medicine

  • Ken Witwer Laboratory

    The Ken Witwer Laboratory investigates extracellular vesicles and RNA in the context of HIV infection and inflammatory disease. We are also actively assessing the effects of diet on extracellular RNA as a potential therapeutic approach.

    Research Areas: extracellular vesicles, HIV, inflammation, RNA

    Principal Investigator

    Kenneth Witwer, Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • Maheshwari Lab

    We study the pathogenesis of neonatal necrotizing enterocolitis, which is a leading cause of morbidity and mortality in premature infants.

    Research Areas: blood transfusions, intestinal injury, neonate, inflammation, premature infants, macrophages

    Principal Investigator

    Akhil Maheshwari, M.B.B.S., M.D.

    Department

    Pediatrics

  • Mark Liu Lab

    Research in the Mark Liu Lab explores several areas of pulmonary and respiratory medicine. Our studies primarily deal with allergic inflammation, chronic obstructive pulmonary disease (COPD) and asthma, specifically immunologic responses to asthma. We have worked to develop a microfluidic device with integrated ratiometric oxygen sensors to enable long-term control and monitoring of both chronic and cyclical hypoxia. In addition, we conduct research on topics such as the use of magnetic resonance angiography in evaluating intracranial vascular lesions and tumors as well as treatment of osteoporosis by deep sea water through bone regeneration.

    Research Areas: respiratory system, pulmonary medicine, asthma, COPD, inflammation, hypoxia

    Principal Investigator

    Mark Liu, M.D.

    Department

    Medicine

  • Maryam Jahromi Lab

    The Maryam Jahromi Lab researches infectious diseases such as influenza, tuberculosis, endocarditis, viral hemorrhagic fevers, brucellosis, Clostridium difficile and Crimean-Congo hemorrhagic fever. We are particularly interested in the impact of the influenza vaccine on systemic inflammation. Recent areas of focus include the relationship between influenza vaccination and cardiovascular outcomes, the emergence of Crimean-Congo hemorrhagic fever in Iran, and prospects for vaccines and therapies for Crimean-Congo hemorrhagic fever.

    Research Areas: vaccines, infectious disease, patient outcomes, inflammation, cardiovascular diseases, flu, Crimean-Congo hemorrhagic fever

    Principal Investigator

    Maryam Keshtkar Jahromi, M.D., M.P.H.

    Department

    Medicine

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