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Displaying 11 to 20 of 39 results for inflammation

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  • Devreotes Laboratory

    The Devreotes Laboratory is engaged in genetic analysis of chemotaxis in eukaryotic cells. Our long-term goal is a complete description of the network controlling chemotactic behavior. We are analyzing combinations of deficiencies to understand interactions among network components and carrying out additional genetic screens to identify new pathways involved in chemotaxis. A comprehensive understanding of this fascinating process should lead to control of pathological conditions such as inflammation and cancer metastasis.

    Research Areas: biochemistry, cell biology, chemotaxis, cancer, genomics, inflammation

    Lab Website

    Principal Investigator

    Peter Devreotes, Ph.D.

    Department

    Cell Biology

  • Edgar Miller Lab

    Research in the Edgar Miller Lab focuses on nutrition, hypertension and kidney disease. Current projects include a National Heart, Lung, and Blood Institute study on dietary carbohydrate and glycemic index effects on markers of oxidative stress, inflammation and kidney function; and a National Institute of Diabetes and Digestive and Kidney Diseases randomized controlled trial that examines the effects of omega-3 fatty acid supplementation on urine protein excretion in diabetic kidney disease.

    Research Areas: nutrition, kidney diseases, diabetes, inflammation

    Principal Investigator

    Edgar Miller, M.D., Ph.D.

    Department

    Medicine

  • Edward Chen Lab

    Research efforts in the Edward Chen Lab focus on bleomycin-induced pulmonary fibrosis and granulomatous inflammation as well as clinical and translational studies in sarcoidosis. Our studies have included topics such as the etiologies of sarcoidosis, hylleraas hydride binding energy in diatomic electron affinities, and molecular convergence of neurodevelopmental disorders. We have also investigated the use of quantitative mass spectrometric analysis to better understand the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.

    Research Areas: pulmonary medicine, sarcoidosis, granulomatous inflammation, pulmonary fibrosis

    Principal Investigator

    Edward Chen, M.D.

    Department

    Medicine

  • Florin Selaru Lab

    Research interests in the Florin Selaru Lab comprise the molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract.

    Research Areas: gastroenterology, cancer, inflammation, molecular biology

    Principal Investigator

    Florin Selaru, M.D.

    Department

    Medicine

  • Franco D’Alessio Lab

    The Franco D’Alessio Lab investigates key topics within the fields of critical care, internal and pulmonary medicine. We primarily explore immunological determinants of acute lung inflammation and repair. Our lab also investigates age-dependent lung immune response in patients with acute lung injury and acute respiratory distress syndrome (ARDS), regulatory T-cells in lung injury and repair, and modulation of alveolar macrophage innate immune response in ARDS.

    Research Areas: critical care medicine, acute respiratory distress syndrome, acute lung injury, lung inflammation, lung disease, T cells

    Principal Investigator

    Franco D'Alessio, M.D.

    Department

    Medicine

  • Healthy Brain Program

    The Brain Health Program is a multidisciplinary team of faculty from the departments of neurology, psychiatry, epidemiology, and radiology lead by Leah Rubin and Jennifer Coughlin. In the hope of revealing new directions for therapies, the group studies molecular biomarkers identified from tissue and brain imaging that are associated with memory problems related to HIV infection, aging, dementia, mental illness and traumatic brain injury. The team seeks to advance policies and practices to optimize brain health in vulnerable populations while destigmatizing these brain disorders.

    Current and future projects include research on: the roles of the stress response, glucocorticoids, and inflammation in conditions that affect memory and the related factors that make people protected or or vulnerable to memory decline; new mobile apps that use iPads to improve our detection of memory deficits; clinical trials looking at short-term effects of low dose hydrocortisone and randomized to 28 day...s of treatment; imaging brain injury and repair in NFL players to guide players and the game; and the role of inflammation in memory deterioration in healthy aging, patients with HIV, and other neurodegenerative conditions. view less

    Research Areas: HIV infection, mental illness, aging, traumatic brain injury, dementia

  • John Schroeder Lab

    The John Schroeder Lab focuses on understanding the role human basophils and mast cells play in allergic reactions, as it relates not only to their secretion of potent inflammatory mediators (e.g., histamine and leukotriene C4) but also to their production of pro-inflammatory cytokines. We have long utilized human cells rather than cell lines in order to address the parameters, signal transduction and pharmacological aspects underlying clinically relevant basophil and mast cell responses. As a result, the lab has established protocols for rapidly isolating large numbers of basophils at high purity from human blood and for growing culture-derived mast cells/basophils from human progenitor cells. A variety of assays and techniques are also in place for concurrently detecting cytokines and mediators following a wide range of stimuli. These have facilitated the in vitro testing of numerous anti-allergic drugs for inhibitory activity on basophil and mast cell activation. The lab also studie...s counter-regulation between the IgE and innate immune receptors on human immature dendritic cell subtypes. view more

    Research Areas: cell biology, allergies, inflammation

    Principal Investigator

    John Schroeder, Ph.D.

    Department

    Medicine

  • Kazuyo Yamaji-Kegan Lab

    Research in the Kazuyo Yamaji-Kegan Lab seeks to better understand the mechanisms, regulation and functional outcomes of a patient’s Th2 immune response during the development of pulmonary hypertension. Our team has demonstrated a direct connection between Th2 cytokine interleukin (IL)-4 and pulmonary vascular growth response; we’re now exploring the mechanisms of endothelial cell injury and subsequent Th2 immune response as it relates to cardiopulmonary diseases. In addition, we are researching pulmonary vascular angiogenesis, vasculogenesis and inflammation using in vivo physiology, in vitro cell biology, and genetic and biochemical methodology.

    Research Areas: pulmonary hypertension, pulmonary medicine, cardiopulmonary diseases, immune system

  • Ken Witwer Laboratory

    The Ken Witwer Laboratory investigates extracellular vesicles and RNA in the context of HIV infection and inflammatory disease. We are also actively assessing the effects of diet on extracellular RNA as a potential therapeutic approach.

    Research Areas: extracellular vesicles, HIV, inflammation, RNA

    Principal Investigator

    Kenneth Witwer, Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • Maheshwari Lab

    We study the pathogenesis of neonatal necrotizing enterocolitis, which is a leading cause of morbidity and mortality in premature infants.

    Research Areas: blood transfusions, intestinal injury, neonate, inflammation, premature infants, macrophages

    Principal Investigator

    Akhil Maheshwari, M.B.B.S., M.D.

    Department

    Pediatrics

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