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Research Lab Results for infections

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  • Retrovirus Laboratory

    Principal Investigator:
    Janice Clements, Ph.D.
    Molecular and Comparative Pathobiology

    Research in the Retrovirus Laboratory focuses on the molecular virology and pathogenesis of len...tivirus infections. In particular, we study the simian immunodeficiency virus (SIV) to determine the molecular basis for the development of HIV CNS, pulmonary and cardiac disease.

    Research projects include studies of viral molecular genetics and host cell genes and proteins involved in the pathogenesis of disease. We are also interested in studies of lentivirus replication in macrophages and astrocytes and their role in the development of disease. These studies have led us to identify the viral genes that are important in neurovirulence of SIV and the development of CNS disease including NEF and the TM portion of ENV. The mechanisms of the action of these proteins in the CNS are complex and are under investigation. We have also developed a rapid, consistent SIV/macaque model in which we can test the ability of various antiviral and neuroprotective agents to reduce the severity of CNS and pulmonary disease.
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    Research Areas: HIV, genomics, pulmonology, SIV, cardiology, lentivirus
  • Sara Cosgrove Lab

    Principal Investigator:
    Sara Cosgrove, M.D.
    Medicine

    The Sara Cosgrove Lab researches how infections with antibiotic-resistant bacteria affect patie...nts. We are interested in the methods needed to make sure patients receive the best possible antibiotic treatment, including the development of tools and programs to promote the rational use of antimicrobials. We also study the epidemiology and management of S. aureus bacteremia. view more

    Research Areas: epidemiology, antimicrobials, antibiotics, resistant organisms
  • Schneck Lab

    Lab Website
    Principal Investigator:
    Jonathan Schneck, M.D., Ph.D.
    Pathology

    Effective immune responses are critical for control of a variety of infectious disease includin...g bacterial, viral and protozoan infections as well as in protection from development of tumors. Central to the development of an effective immune response is the T lymphocyte which, as part of the adaptive immune system, is central in achieving sterilization and long lasting immunity. While the normal immune responses is tightly regulated there are also notable defects leading to pathologic diseases. Inactivity of tumor antigen-specific T cells, either by suppression or passive ignorance allows tumors to grow and eventually actively suppress the immune response. Conversely, hyperactivation of antigen-specific T cells to self antigens is the underlying basis for many autoimmune diseases including: multiple sclerosis; arthritis; and diabetes. Secondary to their central role in a wide variety of physiologic and pathophysiologic responses my lab takes a broad-based approach to studying T cell responses. view more

    Research Areas: t-cell responses, pathologic diseases, autoimmune diseases, pathology, immune system
  • Sean Berenholtz Lab

    Lab Website

    Work in the Sean Berenholtz Lab focuses on patient safety, ICU care, quality health care and ev...idence-based medicine. Two notable and successful projects include the National On The Cusp: Stop BSI project, which was implemented in 47 states with the goal of eliminating bloodstream infections, and the Agency for Healthcare Research and Quality (AHRQ)-funded Keystone ICU project, which improved communication and teamwork and reduced hospital-acquired infections in more than 100 ICUs in Michigan. One recent study focused on ventilator-associated pneumonia (VAP), one of the most common type of health care-associated infections in the ICU. Existing VAP prevention intervention bundles vary widely on the interventions, but our research team described a structured approach for developing a new VAP prevention bundle. view more

    Research Areas: patient safety, quality improvement, infections, ICU, evidence-based medicine, quality of care
  • Stuart C. Ray Lab

    Lab Website
    Principal Investigator:
    Stuart Ray, M.D.
    Medicine

    Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and a...n increasing cause of death in persons living with HIV/AIDS. Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance. We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV. view more

    Research Areas: immunology, Hepatitis, AIDS, HIV, hepatitis B, hepatitis C, liver diseases, synthetic biology
  • The Sfanos Lab

    Lab Website
    Principal Investigator:
    Karen Sfanos, Ph.D., M.S.
    Pathology

    The Sfanos Lab studies the cellular and molecular pathology of prostate disease at the Johns Ho...pkins University School of Medicine. We are specifically interested in agents that may lead to chronic inflammation in the prostate, such as bacterial infections and prostatic concretions called corpora amylacea. Our ongoing studies are aimed at understanding the influence of prostate infections and inflammation on prostate disease including prostate cancer and benign prostatic hyperplasia (BPH). The laboratory also focuses on the influence of the microbiome on prostate disease development, progression, and/or resistance to therapy. view more

    Research Areas: disease resistance, prostate cancer, prostate, benign prostatic hyperplasia, prostate disease, chronic inflammation
  • The Transplant and Oncology Infectious Diseases (TOID) Center

    Lab Website
    Principal Investigator:
    Kieren Marr, M.D.
    Medicine

    The mission of the Transplant and Oncology Infectious Diseases (TOID) Center is to expand insti...tutional expertise in clinical and academic activities focused on infectious complications in transplant (solid organ and stem cell) and oncology patients at Johns Hopkins medical institutions. Key efforts include developing standardized algorithms for the prevention and treatment of infections in these vulnerable patients and to establish an expanded infrastructure to facilitate clinical and translational studies at TOID. Current research projects focus on diagnostics for invasive fungal infections and specialized studies of the pathogenesis of candidiasis and aspergillosis. view more

    Research Areas: transplants, candidiasis, fungal infections, infectious disease, cancer, aspergillosis
  • Thomas Grader-Beck Lab

    Principal Investigator:
    Thomas Grader-Beck, M.D., Ph.D.
    Medicine

    Research in the Thomas Grader-Beck Lab aims to understand the pathogenesis of systemic autoimmu...ne diseases—particularly systemic lupus erythematosus (SLE) and Sjögren’s syndrome—by taking a translational approach. Autoantibodies (antibodies that target self-molecules) are believed to contribute significantly to the disease process. We are studying mechanisms that may make self-structures immunogenic. We theorize that certain post-translational antigen modifications, which can occur in infections or malignant transformation, result in the expression of neoepitopes that spread autoimmunity in the proper setting. The team has combined studies that employ a number of mouse strains, certain gene-deficient mice and human biological specimens. view more

    Research Areas: Sjogren's syndrome, antibodies, autoimmune diseases, self-molecules, systemic lupus erythematosus
  • Todd Dorman Lab

    Research conducted in the Todd Dorman Lab examines the use of informatics in intensive care set...tings as it relates to remote patient monitoring, safety and management strategies. Specific areas of interest include the surgical stress response; aminoglycoside antibiotics; fungal infections; renal failure; pharmacokinetic models of drug administration; and ICU triage and its impact on disaster preparedness. view more

    Research Areas: fungal infections, patient safety, informatics, disaster preparedness, aminoglycoside antibiotics, surgical stress response, ICU, patient monitoring
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